Description
An uncoupler is a protonophore (CCCP, FCCP, DNP) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the noncoupled state of ET-capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. ยป MiPNet article
Abbreviation: U
List of uncouplers
- Bioblast links: Uncoupling - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Specific
- ยป Artefacts by single dose uncoupling
- ยป ATP synthase
- ยป CCCP
- ยป Coupling-control protocol
- ยป DNP
- ยป Dyscoupled respiration
- ยป FCCP
- ยป Is respiration uncoupled - noncoupled - dyscoupled?
- ยป Noncoupled respiration: Discussion
- ยป Uncoupler
- ยป Uncoupled respiration - see ยป Noncoupled respiration
- ยป Uncoupling proteins
- ยป Uncoupling protein 1
- ยป Uncoupler titrations - Optimum uncoupler concentration
- Specific
- Respiratory states and control ratios
- ยป Biochemical coupling efficiency
- ยป Coupling-control state
- ยป Electron-transfer-pathway state
- ยป Electron-transfer pathway
- ET capacity
- ยป E-L coupling efficiency
- ยป Flux control efficiency
- ยป Flux control ratio
- ยป LEAK-control ratio
- ยป LEAK respiration
- ยป Noncoupled respiration
- ยป OXPHOS
- ยป OXPHOS capacity; ยป State 3
- ยป OXPHOS-control ratio, P/E ratio
- ยป Respiratory acceptor control ratio
- ยป ROUTINE-control ratio
- ยป ROUTINE respiration
- ยป ROUTINE state
- ยป State 3u
- ยป State 4
- ยป Uncoupling-control ratio UCR
- Respiratory states and control ratios
- Gnaiger E et al โ MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
- Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
- General (alphabetical order)
- Other keyword lists
- Bioblast links: Force and membrane potential - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Fundamental relationships
- ยป Force
- ยป Affinity
- ยป Flux
- ยป Advancement
- ยป Advancement per volume
- ยป Stoichiometric number
- Fundamental relationships
- mt-Membrane potential and protonmotive force
- ยป Uncoupler
- O2k-Potentiometry
- ยป O2k-Catalogue: O2k-TPP+ ISE-Module
- ยป O2k-Manual: MiPNet15.03 O2k-MultiSensor-ISE
- ยป TPP - O2k-Procedures: Tetraphenylphosphonium
- ยป Specifications: MiPNet15.08 TPP electrode
- ยป Poster
- ยป Unspecific binding of TPP+
- ยป TPP+ inhibitory effect
- O2k-Potentiometry
- O2k-Fluorometry
- ยป O2k-Catalogue: O2k-FluoRespirometer
- ยป O2k-Manual: MiPNet22.11 O2k-FluoRespirometer manual
- ยป Safranin - O2k-Procedures: MiPNet20.13 Safranin mt-membranepotential / Safranin
- ยป TMRM - O2k-Procedures: TMRM
- O2k-Fluorometry
- O2k-Publications
MitoPedia topics:
Uncoupler
Labels:
Regulation: Coupling efficiency;uncoupling
Coupling state: LEAK, ET
HRR: Theory