MitoEAGLE preprint 2017-09-21
| Gnaiger E, Ahn B, Alves MG, Beard DA, Ben-Shachar D, Bishop D, Breton S, Brown GC, Brown RA, Buettner GR, Bumsoo A, Cervinkova Z, Chicco AJ, Coen PM, Collins JL, Crisóstomo L, Davis MS, Dias T, Doerrier C, Fell DA, Filipovska A, Garcia-Roves PM, Garcia-Souza LF, Gonzalo H, Goodpaster BH, Han J, Harrison DK, Hellgren KT, Hernansanz P, Hoppel CL, Iglesias-Gonzalez J, Irving BA, Iyer S, Jansen-Dürr P, Käämbre T, Kane DA, Komlodi T, Kuang J, Laner V, Lee HK, Lemieux H, Lucchinetti E, Makrecka-Kuka M, Meszaros AT, Moisoi N, Molina AJA, Montaigne D, Moore AL, Murray AJ, Porter RK, Nozickova K, Oliveira PF, Oliveira PJ, Orynbayeva Z, Palmeira CM, Pesta D, Petit PX, Pichaud N, Pirkmajer S, Prochownik EV, Renner-Sattler K, Rohlena J, Rossiter HB, Salvadego D, Scatena R, Schartner M, Scheibye-Knudsen M, Scott GR, Singer D, Sobotka O, Spinazzi M, Stocker R, Sumbalova Z, Tanaka M, Tandler B, Tepp K, Tronstad KJ, Tyrrell DJ, Velika B, Vendelin M, Vercesi AE, Watala C, Wei YH, Wieckowski MR, Wolff J, Wüst RCI, Zaugg M, Zorzano A (2017) The protonmotive force and respiratory control: Building blocks of mitochondrial physiology Part 1. MitoEAGLE preprint 2017-09-18(01). |
» Work in progress Last update 2017-09-18: 
- » Versions
Gnaiger E, Ahn B, Alves MG, Beard DA, Ben-Shachar D, Bishop D, Breton S, Brown GC, Brown RA, Buettner GR, Bumsoo A, Cervinkova Z, Chicco AJ, Coen PM, Collins JL, Crisostomo L, Davis MS, Dias T, Doerrier C, Fell DA, Filipovska A, Garcia-Roves PM, Garcia-Souza LF, Gonzalo H, Goodpaster BH, Han J, Harrison DK, Hellgren KT, Hernansanz P, Hoppel CL, Iglesias-Gonzalez J, Irving BA, Iyer S, Jansen-Duerr P, Kaeaembre T, Kane DA, Komlodi T, Kuang J, Laner V, Lee HK, Lemieux H, Lucchinetti E, Makrecka-Kuka M, Meszaros AT, Moisoi N, Molina AJA, Montaigne D, Moore AL, Murray AJ, Porter RK, Nozickova K, Oliveira PF, Oliveira PJ, Orynbayeva Z, Palmeira CM, Pesta D, Petit PX, Pichaud N, Pirkmajer S, Prochownik EV, Renner-Sattler K, Rohlena J, Rossiter HB, Salvadego D, Scatena R, Schartner M, Scheibye-Knudsen M, Schilling JM, Scott GR, Singer D, Sobotka O, Spinazzi M, Stocker R, Sumbalova Z, Tanaka M, Tandler B, Tepp K, Tronstad KJ, Tyrrell DJ, Velika B, Vendelin M, Vercesi AE, Watala C, Wei YH, Wieckowski MR, Wolff J, Wuest RCI, Zaugg M, Zorzano A, Supporting co-authors:, Arandarcikaite O, Bakker BM, Batista Ferreira J, Bernardi P, Boetker HE, Borsheim E, Borutaite V, Bouitbir J, Calabria E, Calbet JA, Carvalho E, Chaurasia B, Clementi E, Collin A, Das AM, De Palma C, Distefano G, Dubouchaud H, Duchen MR, Durham WJ, Dyrstad SE, Ehinger J, Elmer E, Fornaro M, Gan Z, Garlid KD, Garten A, Genova ML, Gourlay CW, Granata C, Haas CB, Haendeler J, Hand SC, Hepple RT, Hickey AJ, Hoel F, Jespersen NR, Jha RK, Kainulainen H, Keppner G, Khamoui AV, Klingenspor M, Koopman WJH, Kowaltowski AJ, Krajcova A, Labieniec-Watala M, Lenaz G, MacMillan-Crow LA, Malik A, Markova M, Menze MA, Methner A, Muntane J, Muntean DM, Neuzil J, Newsom S, O'Gorman D, Oliveira MT, Pak YMK, Patel HH, Pettersen IKN, Pulinilkunnil T, Reboredo P, Robinson MM, Ropelle ER, Røsland GV, Salin K, Sandi C, Sazanov LA, Siewiera K, Silber AM, Skolik R, Smenes BT, Soares FAA, Sokolova I, Sonkar VK, Stankova P, Swerdlow RH, Szabo I, Thyfault JP, Towheed A, Tretter L, Vieyra A, Votion DM, Ward ML, Williams C, Zaugg K (2017) MitoEAGLE preprint
Abstract: Clarity of concepts and consistency of nomenclature are trademarks of a research field across its specializations, facilitating transdisciplinary communication and education. As research and knowledge of mitochondrial physiology expand, the necessity for harmonizing nomenclature concerning mitochondrial respiratory states and rates has become apparent. Peter Mitchell’s concept of the protonmotive force establishes the link between the electrical and chemical components of energy transformation and its coupling in oxidative phosphorylation. This unifying concept provides the framework for developing a consistent terminology of mitochondrial physiology and bioenergetics. We follow IUPAC guidelines on general terms of physical chemistry, extended by concepts of open systems and irreversible thermodynamics. We align the nomenclature of classical bioenergetics on respiratory states with a concept-driven constructive terminology to address the meaning of each respiratory state. Standards for evaluation of respiratory coupling states must be followed for the development of databases of mitochondrial respiratory function in species, tissues and cells studied under diverse physiological and experimental conditions. • Keywords: Mitochondrial respiratory control, coupling control, mitochondrial preparations, protonmotive force, chemiosmotic theory, oxidative phosphorylation, OXPHOS, efficiency, electron transfer system, ETS; proton leak, LEAK, residual oxygen consumption, ROX, State 2, State 3, State 4, normalization, flow, flux • Bioblast editor: Gnaiger E
Labels: MiParea: Respiration, mt-Awareness
Preparation: Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria
Enzyme: Marker enzyme
Regulation: Coupling efficiency;uncoupling, Flux control, mt-Membrane potential, Uncoupler
Coupling state: LEAK, OXPHOS, ETS"ETS" is not in the list (LEAK, ROUTINE, OXPHOS, ET) of allowed values for the "Coupling states" property.
Pathway: ROX
- Contributing co-authors: Confirming to have read the final manuscript, possibly to have made additions or suggestions for improvement, and to agree to implement the recommendations into future manuscripts, presentations and teaching materials. (alphabetical, to be extended)
- Supporting co-authors: Confirming to have read the final manuscript, and to agree to implement the recommendations into future manuscripts, presentations and teaching materials. (alphabetical, to be extended)
- Citation:
- MitoEAGLE preprint 2017-09-18(Version #). The protonmotive force and respiratory control: Building blocks of mitochondrial physiology Part 1. - http://www.mitoeagle.org/index.php/MitoEAGLE_preprint_2017-09-18
Concept
- Phase 1
- » Work in progress: 44 versions: The protonmotive force and respiratory control
- » Discussion and work flow
- Phase 2: MitoEAGLE preprint - on route to let the final publication fly. Feedback, suggestions, and confirmation from co-authors.
- Phase 3: Manuscript submission to a preprint server, such as BioRxiv.
- Phase 4: Manuscript submission for journal publication. Contact the editor(s) of our finally targeted journal(s), to obtain a first opinion if submission to this journal will be adequate. Cell Metabolism and BBA have been mentioned as possible preferences.
