Goodpaster BH

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MiPsociety
COST Action CA15203 MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping


 

Goodpaster BH


MitoPedia topics: EAGLE 

COST: Member COST WG1: WG1


Name Goodpaster Bret H, Prof., PhD.

Director and Senior Investigator

at Translational Research Institute for Metabolism

Professor

at Sanford Burnham Prebys Medical Discovery Institute at Lake Nona

Institution Translational Research Institute for Metabolism and Diabetes,

Florida Hospital & Sanford Burnham Prebys, US

Address 301 East Princeton Street, 32804
City Orlando
State/Province Florida (FL)
Country USA
Email bret.goodpaster@flhosp.org
Weblink Goodpaster at Sanford/Burham Institute
O2k-Network Lab US FL Orlando Goodpaster BH


Labels: Field of research: Basic, Clinical  Topics: Exercise and muscle metabolism 


Publications

 PublishedReference
Doerrier 2019 MitoFit Preprint Arch EA2019Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0009.
Gnaiger 2019 MitoFit Preprint Arch2019Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v4.
Braganza 2019 JCI Insight2019Braganza AC, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248.
Zhang 2018 J Gerontol A Biol Sci Med Sci2018Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM (2018) Impaired mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice. J Gerontol A Biol Sci Med Sci 73:1313-22.
Toledo 2018 Obesity (Silver Spring)2018Toledo FGS, Dubé JJ, Goodpaster BH, Stefanovic-Racic M, Coen PM, DeLany JP (2018) Mitochondrial respiration is associated with lower energy expenditure and lower aerobic capacity in African American women. Obesity (Silver Spring) 26:903-9.
Menshikova 2017 J Gerontol A Biol Sci Med Sci2017Menshikova EV, Ritov VB, Dube JJ, Amati F, Stefanovic-Racic M, Toledo FG, Coen PM, Goodpaster BH (2017) Calorie restriction-induced weight loss and exercise have differential effects on skeletal muscle mitochondria despite similar effects on insulin sensitivity. J Gerontol A Biol Sci Med Sci 73:81-7.
Gusdon 2017 Exp Gerontol2017Gusdon AM, Callio J, Distefano G, O'Doherty RM, Goodpaster BH, Coen PM, Chu CT (2017) Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. Exp Gerontol 90:1-13.
Distefano 2016 J Gerontol A Biol Sci Med Sci2016Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 72:535-42.
Santanasto 2016 Exp Gerontol2016Santanasto AJ, Coen PM, Glynn NW, Conley KE, Jubrias SA, Amati F, Strotmeyer ES, Boudreau RM, Goodpaster BH, Newman AB (2016) The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function. Exp Gerontol 81:1-7.
Coen 2015 Diabetes2015Coen PM, Menshikova EV, Distefano G, Zheng D, Tanner CJ, Standley RA, Helbling NL, Dubis GS, Ritov VB, Xie H, Desimone ME, Smith SR, Stefanovic-Racic M, Toledo FG, Houmard JA, Goodpaster BH (2015) Exercise and weight loss improve muscle mitochondrial respiration, lipid partitioning, and insulin sensitivity after gastric bypass surgery. Diabetes 64:3737-50.
Neufer 2015 Cell Metab2015Neufer PD, Bamman MM, Muoio DM, Bouchard C, Cooper DM, Goodpaster BH, Booth FW, Kohrt WM, Gerszten RE, Mattson MP, Hepple RT, Kraus WE, Reid MB, Bodine SC, Jakicic JM, Fleg JL, Williams JP, Joseph L, Evans M, Maruvada P, Rodgers M, Roary M, Boyce AT, Drugan JK, Koenig JI, Ingraham RH, Krotoski D, Garcia-Cazarin M, McGowan JA, Laughlin MR (2015) Understanding the cellular and molecular mechanisms of physical activity-induced health benefits. Cell Metab 22:4-11.
Woodlief 2015 Obesity (Silver Spring)2015Woodlief TL, Carnero EA, Standley RA, Distefano G, Anthony SJ, Dubis GS, Jakicic JM, Houmard JA, Coen PM, Goodpaster BH (2015) Dose response of exercise training following roux-en-Y gastric bypass surgery: A randomized trial. Obesity (Silver Spring) 23:2454-61.
Ambrosio 2014 Free Radic Biol Med2014Ambrosio F, Brown E, Stolz D, Ferrari R, Goodpaster BH, Deasy B, Distefano G, Roperti A, Cheikhi A, Garciafigueroa Y, Barchowsky A (2014) Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics. Free Radic Biol Med 74C:64-73.
Santanasto 2014 J Gerontol A Biol Sci Med Sci2014Santanasto AJ, Glynn NW, Jubrias SA, Conley KE, Boudreau RM, Amati F, Mackey DC, Simonsick EM, Strotmeyer ES, Coen PM, Goodpaster BH, Newman AB (2014) Skeletal muscle mitochondrial function and fatigability in older adults. J Gerontol A Biol Sci Med Sci 70:1379-85.
DeLany 2014 J Clin Endocrinol Metab2014DeLany JP, Dube JJ, Standley RA, Distefano G, Goodpaster BH, Stefanovic-Racic M, Coen PM, Toledo FG (2014) Racial differences in peripheral insulin sensitivity and mitochondrial capacity in the absence of obesity. J Clin Endocrinol Metab 99:4307-14.
Goodpaster 2014 Diabetes2014Goodpaster BH, Coen PM (2014) Improved mitochondrial function is linked with improved insulin sensitivity through reductions in FFA. Diabetes 63:2611-2.
Dube 2014 Am J Physiol Endocrinol Metab2014Dube JJ, Coen PM, DiStefano G, Chacon AC, Helbling NL, Desimone ME, Stafanovic-Racic M, Hames KC, Despines AA, Toledo FG, Goodpaster BH (2014) Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance. Am J Physiol Endocrinol Metab 307:E1117-24.
Coen 2013 J Gerontol A Biol Sci Med Sci2013Coen PM, Jubrias SA, Distefano G, Amati F, Mackey DC, Glynn NW, Manini TM, Wohlgemuth SE, Leeuwenburgh C, Cummings SR, Newman AB, Ferrucci L, Toledo FG, Shankland E, Conley KE, Goodpaster BH (2013) Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults. J Gerontol A Biol Sci Med Sci 68:447-55.
Coen 2013 Obesity (Silver Spring)2013Coen PM, Hames KC, Leachman EM, Delany JP, Ritov VB, Menshikova EV, Dubé JJ, Stefanovic-Racic M, Toledo FG, Goodpaster BH (2013) Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity. Obesity (Silver Spring) 21:2362-71.
Sitnick 2013 Diabetes2013Sitnick MT, Basantani MK, Cai L, Schoiswohl G, Yazbeck CF, Distefano G, Ritov V, Delany JP, Schreiber R, Stolz DB, Gardner NP, Kienesberger PC, Pulinilkunnil T, Zechner R, Goodpaster BH, Coen P, Kershaw EE (2013) Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes 62:3350-6.
Chomentowski 2011 J Clin Endocrinol Metab2011Chomentowski P, Coen PM, Radiková Z, Goodpaster BH, Toledo FG (2011) Skeletal muscle mitochondria in insulin resistance: Differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility. J Clin Endocrinol Metab 96: 494-503.

Abstracts

 PublishedReference
Doerrier 2018 MiP2018c2018
Carolina Doerrier
Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.
Coen 2017 Abstract MITOEAGLE Barcelona2017
COST Action MitoEAGLE
To bring MitoEAGLE and MoTrPAC together.
Distefano 2017 MiPschool Obergurgl2017
Giovanna Distefano
Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects.
Doerrier 2017 MiP2017 WG22017
Carolina Anneliese Doerrier
Upper limit of OXPHOS capacity in permeabilized myofibers: effect of oxygen, ADP and blebbistatin in MiR05Cr and Buffer Z.
Goodpaster 2016 Abstract MitoFit Science Camp 20162016The molecular transducers of physical activity consortium (MoTrPAC) and MitoEAGLE: exercise effects on mitochondria.
Zhang 2015 Abstract MiPschool Greenville 20152015Skeletal muscle NAMPT overexpression prevents mitochondrial dysfunction during hindlimb unloading induced muscle atrophy.
Goodpaster 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Goodpaster 2015 Fatty Acid Oxidation O2k-Network Discussion Forum
Coen 2014 Abstract MiP20142014Exercise improves insulin sensitivity and muscle mitochondrial respiration following Roux-en-Y gastric bypass surgery.
DeLany 2013 TOS2013Skeletal muscle mitochondrial respiration is lower in African American compared to Caucasian women and is associated with resting metabolic rate and cardiorespiratory fitness.
Distefano 2012 Abstract IOC682012Distefano G, Dube JJ, Helbling NL, Ritov VB, Stefanovic-Racic M, Toledo FGS, Ng J, Goodpaster BH, Coen PM (2012) Human skeletal muscle mitochondria respiration: The influence of aging, adiposity and aerobic fitness. MiPNet17.08.

Feedback

  • We love our O2k. We have performed measurements in more than 300 muscle biopsies to date, and Paul Coen and I just got a paper accepted in Journal of Gerontology highlighting the measurements related to function in the elderly (2012-10-05).


MitoEAGLE

        • Benefits for COST and for the COST Action MitoEAGLE and for COST International Partner Countries
The TRI-MD is a is a joint venture between Florida Hospital and Sanford-Burnham Medical Research Institute that is dedicated to the study of obesity, metabolism, diabetes, and the metabolic origins of cardiovascular disease.
Our group’s research program is in part focused on skeletal muscle mitochondrial energetics in the context of aging, obesity and exercise. Over the past 10 years we have conducted over 1000 respirometry assays in human muscle and so we are in an excellent position to support the scientific mission of the COST Action MitoEAGLE. In addition, we are keen to share our experience in human permeabilized muscle fiber bundle preparation. To this end we feel that our contribution may best benefit the scientific goal of Working Group #2.
In summary, we are keen to join and contribute to the important scientific mission of the Horizon 2020 COST Action CA15203 MitoEAGLE.


Participated at

Links