Molina AJA

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MiPsociety
COST Action CA15203 MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping


 

Molina AJA


MitoPedia topics: EAGLE 

COST: Member COST WG1: WG1


Name Molina Anthony JA, PhD, Associate Professor, Vice Chief of Research

ORCID ID

Institution
Anthony Molina
Division of Geriatrics and Gerontology,

Department of Medicine,

University of San Diego, US

Address Stein Clinical Research Building #127

9500 Gilman Drive, CA 92093-0665

City San Diego; La Jolla
State/Province California (CA)
Country USA
Email ajmolina@ucsd.edu
Weblink
O2k-Network Lab US CA San Diego Molina AJA, US NC Winston-Salem Molina AJA


Labels: Field of research: Basic, Clinical 



Publications

 PublishedReference
Gnaiger 2019 MitoFit Preprint Arch2019Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v4.
Douros 2019 JCI Insight2019Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina A, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D (2019) Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight 4:126688.
Gonzalez-Armenta 2019 J Nutr2019Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr [Epub ahead of print].
Tyrrell 2016 Redox Biol2016Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ (2016) Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol 10:65-77.
Tyrrell 2015 Exp Gerontol2015Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ (2015) Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol 70:84-91.

Abstracts

 PublishedReference
Amick 2017 MiPschool Obergurgl2017
Amick picture.jpg
Bioenergetic profiling of mitochondria isolated from three distinct brain regions relevant to AD pathology in non-human primates.
Collins 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
The effects of a Mediterranean versus Western diet on nonhuman primate skeletal muscle bioenergetics.
Molina 2017 MiPschool Obergurgl2017
Anthony Molina
Scope and limitations of functional mitochondrial diagnosis in blood cells.
Tyrrell 2015 Abstract MiPschool Greenville 20152015Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults.

Participated at


UPBEAT project

The following webpage summarizes our current Aging Center projects: Aging Center projects
US NC Winston-Salem Molina AJA.png



UPBEAT- Understanding the Physiology and BioEnergetics of Aging
Age-related bioenergetic decline underlies numerous features of aging, including the development of age-related diseases and disorders. To date, there is a limited understanding of how mitochondrial bioenergetics changes in the context of normal human aging. The goal of UPBEAT is to address this gap in knowledge and to generate a database of bioenergetic profiles from healthy individuals across a spectrum of ages. A key feature of UPBEAT is its design to serve as a healthy control group for ongoing and future research projects. For example, the role of mitochondrial bioenergetics in in several age-related diseases is currently being investigated by comparing data from patients and age-matched UPBEAT participants.
Highly comprehensive bioenergetic profiling is being achieved by respirometry of circulating cells and biopsied skeletal muscle tissue using complementary approaches and protocols. In addition to standard clinical measures, analyses of physical ability and exercise capacity are being conducted. Current recruitment is focused on healthy older adults; younger age groups will follow.


Principal Investigator:
Anthony J.A. Molina. PhD
Wake Forest School of Medicine


-This study is supported by the American Heart Association and the National Institute on Aging.
-Additional support and technical expertise provided by Oroboros Instruments (Innsbruck, Austria).


To download the UPBEAT project summary press here.


Visiting scientist in the Oroboros MitoFit Laboratory

O2k-Network

Anthony JA Molina: Visiting scientist at the Oroboros MitoFit Laboratory

  • October 04 to 06 2015