Viruses and mitochondrial medicine: Difference between revisions

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Viruses and mitochondrial medicine

Description

Not enough is known about viruses and mitochondrial medicine, although several studies point towards a link between viral infection and mitochondrial dysfunction using high-resolution respirometry, with potential impact on drug development.

Abbreviation: Virus-mt-Medicine

Communicated by Gnaiger E 2020-02-23, last update 2020-02-29

News: Coronavirus - COVID-19 or 2019-nCoV

2019-nCoV (WHO), SARS-CoV-2 (International Committee on Taxonomy of Viruses)

COVID-19 — New insights on a rapidly changing epidemic del Rio C, Malani PN (2020) JAMA. Published online February 28, 2020. doi:10.1001/jama.2020.3072

As of February 27, 2020, more than 82 000 cases of coronavirus disease 2019 (COVID-19) (the disease caused by SARS-CoV-2) and 2800 deaths have been reported, of which approximately 95% of cases and 97% of deaths are in China.1 Cases have now been reported in 49 other countries.
The reproductive number (R0) (the expected number of secondary cases produced by a single infected person in a susceptible population) for SARS-CoV-2, although still preliminary, is estimated between 2 and 3, suggesting a higher pandemic potential than SARS.
The data surrounding the biology, epidemiology, and clinical characteristics of the SARS-CoV-2 virus have been growing daily, with more than 400 articles listed in PubMed.
Named 2019-nCoV by the WHO and SARS-CoV-2 by the International Committee on Taxonomy of Viruses, this virus is a new human-infecting Betacoronavirus that, based on its genetic proximity to 2 bat-derived SARS-like coronaviruses, likely originated in chrysanthemum bats.

Coronavirus disease 2019 and influenza Livingston E, Bucher K, Rekito A (2020) JAMA. Published online February 26, 2020. doi:10.1001/jama.2020.2633

Although a great deal of attention has been given to the coronavirus disease 2019 (COVID-19) epidemic, it is most severe in one area of China and appears to have limited clinical ramifications outside of that region. Lost in the discussion about COVID-19 is the fact that the US is experiencing a severe influenza season that has already resulted in more than 16 000 deaths.

»Previous communications«

Publications: Viruses and mt-medicine

	Year	Reference	Organism	Tissue;cell	Stress
Brown 2020 BMJ	2020	Brown Robert A, Rhein Helga M, Alipio Mark M, Annweiler Cedric, Gnaiger Erich, Holick Michael F, Boucher Barbara J, Duque Gustavo, Féron François, Kenny Rose Anne, Montero-Odasso Manuel, Minisola Salvatore, Rhodes Jonathan, Haq Afrozul, Bejerot Susanne, Reiss Lina AJ, Zgaga Lina, Crawford Michael A, Fricker Rosemary A, Cobbold Peter, Lahore Henry W, Humble Mats B, Sarkar Amrita, Karras Spiros, Iglesias-Gonzalez Javier, Gezen-Ak Duygu, Dursun Erdinc, Cooper Isabella, Grimes David, de Voil Cedric WB (2020) COVID-19 ’ICU’ risk – 20-fold greater in the vitamin D deficient. BAME, African Americans, the older, institutionalised and obese, are at greatest risk. Sun and ‘D’-supplementation – game-changers? Research urgently required. https://doi.org/10.1136/bmj.m1548	Human	Lung;gill Fat
Brown 2020 MitoFit Preprint Arch	2020	Brown RA, Sarkar A (2020) Vitamin D deficiency: a factor in COVID-19, progression, severity and mortality? – An urgent call for research. https://doi.org/10.26124/mitofit:200001	Human
Ledur 2020 Sci Rep	2020	Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.	Human	Nervous system
Weinstein 2019 bioRxiv	2019	Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 .	Human	Other cell lines Lymphocyte
Du 2019 J Virol	2019	Du C, Duan Y, Wang XF, Lin Y, Na L, Wang X, Chen K, Wang X (2019) Attenuation of equine lentivirus alters mitochondrial protein expression profile from inflammation to apoptosis. J Virol 93:e00653-19.	Horse	Blood cells Other cell lines	Cell death
Braz-De-Melo 2019 Sci Rep	2019	Braz-De-Melo HA, Pasquarelli-do-Nascimento G, Corrêa R, das Neves Almeida R, de Oliveira Santos I, Prado PS, Picolo V, de Bem AF, Pizato N, Magalhães KG (2019) Potential neuroprotective and anti-inflammatory effects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells. Sci Rep 9:20119.	Human	Neuroblastoma
Fernandes-Siqueira 2018 mSphere	2018	Fernandes-Siqueira LO, Zeidler JD, Sousa BG, Ferreira T, Da Poian AT (2018) Anaplerotic role of glucose in the oxidation of endogenous fatty acids during Dengue virus infection. mSphere 3.pii: e00458-17.	Human	Liver Other cell lines
Qu 2018 FASEB J	2018	Qu C, Zhang S, Wang W, Li M, Wang Y, van der Heijde-Mulder M, Shokrollahi E, Hakim MS, Raat NJH, Peppelenbosch MP, Pan Q (2018) Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target. FASEB J 33:1008-19.	Human	Liver
Wang 2018 Mol Med Rep	2018	Wang B, Li W, Fang H, Zhou H (2018) Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis. Mol Med Rep 19:320-26. https://doi.org/10.3892/mmr.2018.9619	Human	Liver
Xia 2016 RSC Adv	2016	Xia Z, Yi X, Zhuang Y (2016) Stable over-expression of the human malate–aspartate NADH shuttle member Aralar I in PK15 cells improves energy metabolism and enhances proliferation of porcine circovirus-2. RSC Adv 6:61268-77.	Pig	Kidney
Silva 2012 PLOS ONE	2012	Silva da Costa L, Pereira da Silva AP, Da Poian AT, El-Bacha T (2012) Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis virus: implications to viral replication and neuronal death. PLoS One 7:e33871.	Mouse	Neuroblastoma	Mitochondrial disease
El-Bacha 2012 Int J Biochem Cell Biol	2012	El-Bacha T, Da Poian AT (2012) Virus-induced changes in mitochondrial bioenergetics as potential targets for therapy. Int J Biochem Cell Biol 45:41-6.	Human Mouse	Nervous system Liver Fibroblast	Oxidative stress;RONS
Morse 2012 J Infect Dis	2012	Morse CG, Voss JG, Rakocevic G, McLaughlin M, Vinton CL, Huber C, Hu X, Yang J, Huang da W, Logun C, Danner RL, Rangel ZG, Munson PJ, Orenstein JM, Rushing EJ, Lempicki RA, Dalakas MC, Kovacs JA (2012) HIV infection and antiretroviral therapy have divergent effects on mitochondria in adipose tissue. J Infect Dis 205:1778-1787.	Human	Skeletal muscle Blood cells Fat
Mutuel 2010 Virology	2010	Mutuel D, Ravallec M, Chabi B, Multeau C, Salmon JM, Fournier P, Ogliastro M (2010) Pathogenesis of Junonia coenia densovirus in Spodoptera frugiperda: a route of infection that leads to hypoxia. Virology 403:137-44.	Hexapods		Ischemia-reperfusion Oxidative stress;RONS
El-Bacha 2007 Biochim Biophys Acta	2007	El-Bacha T, Midlej V, Pereira da Silva AP, Silva da Costa L, Benchimol M, Galina A, Da Poian AT (2007) Mitochondrial and bioenergetic dysfunction in human hepatic cells infected with dengue 2 virus. Biochim Biophys Acta 1772:1158-66.	Human	Liver	Cell death
Yuan 2006 Mol Cells	2006	Yuan X, Shan Y, Yao Z, Li J, Zhao Z, Chen J, Cong Y (2006) Mitochondrial location of severe acute respiratory syndrome coronavirus 3b protein. Mol Cells 21:186–91.	Human		Cell death
Vrbacky 2003 Physiol Res	2003	Vrbacký M, Krijt J, Drahota Z, Mĕlková Z (2003) Inhibitory effects of Bcl-2 on mitochondrial respiration. Physiol Res 52:545-54.	Human Other mammals	Endothelial;epithelial;mesothelial cell Other cell lines HeLa	Cell death

MitoPedia concepts: MiP concept

@@ Line 3: / Line 3: @@
 |description=Not enough is known about '''viruses and mitochondrial medicine''', although several studies point towards a link between viral infection and mitochondrial dysfunction using high-resolution respirometry, with potential impact on drug development.
 }}
-  Communicated by [[Gnaiger E]] 2020-02-23, last update 2020-02-26
+  Communicated by [[Gnaiger E]] 2020-02-23, last update 2020-02-29
 == News: Coronavirus - COVID-19 or 2019-nCoV ==
-::::* [https://jamanetwork.com/journals/jama/fullarticle/2759815?guestAccessKey=9b2031e3-e18d-4938-a6e3-ce9f55643093&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=etoc&utm_term=022520 '''Coronavirus infections — more than just the common cold'''] Paules CI, Marston HD, Fauci AS (2020) JAMA 323:707-8.
+:::: 2019-nCoV (WHO), SARS-CoV-2 (International Committee on Taxonomy of Viruses)
-:::::: "Human coronaviruses (HCoVs) have long been considered inconsequential pathogens, causing the “common cold” in otherwise healthy people. However, in the 21st century, 2 highly pathogenic HCoVs — severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) — emerged from animal reservoirs to cause global epidemics with alarming morbidity and mortality. In December 2019, yet another pathogenic HCoV, 2019 novel coronavirus (2019-nCoV), was recognized in Wuhan, China, and has caused serious illness and death. The ultimate scope and effect of this outbreak is unclear at present as the situation is rapidly evolving."
-:::::: "The emergence of yet another outbreak of human disease caused by a pathogen from a viral family formerly thought to be relatively benign underscores the perpetual challenge of emerging infectious diseases and the importance of sustained preparedness."
-::::* [https://jamanetwork.com/journals/jama/fullarticle/2760500?guestAccessKey=e44d7c0e-262d-48a8-9770-0dc7b35e6ffe&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=etoc&utm_term=022520 '''The novel coronavirus originating in Wuhan, China. Challenges for global health governance''']  Phelan AL, Katz R, Gostin LO (2020) JAMA 323:709-10.
+::::* [https://jamanetwork.com/journals/jama/fullarticle/2762510?guestAccessKey=6fa65576-ad53-4e75-aaae-aad327c76ea4&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=022820 '''COVID-19 — New insights on a rapidly changing epidemic''']  del Rio C, Malani PN (2020) JAMA. Published online February 28, 2020. doi:10.1001/jama.2020.3072
-:::::: "China rapidly isolated the novel coronavirus on January 7 and shared viral genome data with the international community 3 days later."
+::::::* As of February 27, 2020, more than 82 000 cases of coronavirus disease 2019 (COVID-19) (the disease caused by SARS-CoV-2) and 2800 deaths have been reported, of which approximately 95% of cases and 97% of deaths are in China.1 Cases have now been reported in 49 other countries.
-:::::: "The sheer scale of China’s cordon sanitaire across Hubei Province is unprecedented."
+::::::* The reproductive number (R0) (the expected number of secondary cases produced by a single infected person in a susceptible population) for SARS-CoV-2, although still preliminary, is estimated between 2 and 3, suggesting a higher pandemic potential than SARS.
-:::::: "The health system should facilitate and encourage individuals to promptly seek testing and treatment, as well as to cooperate with containment measures such as isolation and contact investigations."
+::::::* The data surrounding the biology, epidemiology, and clinical characteristics of the SARS-CoV-2 virus have been growing daily, with more than 400 articles listed in PubMed.
-:::::: "The 2019-nCoV outbreak is currently not under control, with a high risk of spread in China and globally. Managing the outbreak requires international cooperation using traditional public health strategies that ultimately succeeded with SARS. The scientific community must fully characterize 2019-nCoV; epidemiologists must conduct intensive contact investigations; researchers should move rapidly toward development of medical countermeasures; and supply chains must mobilize to meet human needs for food, water, and medicine."
+::::::* Named 2019-nCoV by the WHO and SARS-CoV-2 by the International Committee on Taxonomy of Viruses, this virus is a new human-infecting Betacoronavirus that, based on its genetic proximity to 2 bat-derived SARS-like coronaviruses, likely originated in chrysanthemum bats.
+::::* [https://jamanetwork.com/journals/jama/fullarticle/2762386?guestAccessKey=274f1500-8d22-46e2-8be7-6e1120a3e001&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_term=mostread&utm_content=olf-widget_02282020 '''Coronavirus disease 2019 and influenza'''] Livingston E, Bucher K, Rekito A (2020) JAMA. Published online February 26, 2020. doi:10.1001/jama.2020.2633
+::::::* Although a great deal of attention has been given to the coronavirus disease 2019 (COVID-19) epidemic, it is most severe in one area of China and appears to have limited clinical ramifications outside of that region. Lost in the discussion about COVID-19 is the fact that the US is experiencing a severe influenza season that has already resulted in more than 16 000 deaths.
-== References: Viruses and mt-medicine ==
+:::: [[Talk:Viruses and mitochondrial medicine | »Previous communications«]]
+== Publications: Viruses and mt-medicine ==
 {{#ask:[[MiP area::mt-Medicine]] [[Additional label::Virus]]
 |?Was published in year=Year