Torres-Quesada 2022 Abstract Bioblast

Torres-Quesada Omar, Strich S, Stefan E (2022) Kinase perturbations redirect mitochondrial function. Bioblast 2022: BEC Inaugural Conference. »MitoFit Preprint«

Link: Bioblast 2022: BEC Inaugural Conference

Torres-Quesada Omar, Strich Sophie, Stefan Eduard (2022)

Event: Bioblast 2022

Protein kinases take the center stage in numerous signaling pathways by phosphorylating compartmentalized protein substrates for controlling cell proliferation, cell cycle and metabolism. Kinase dysfunctions have been linked to numerous human diseases such as cancer. This has led to the development of kinase inhibitors which aim to target oncogenic kinase activities. The specificity of the cancer blockers depends on the range of targeted kinases. Therefore, the question arises of how cell-type-specific off-target effects impair the specificities of cancer drugs. Blockade of kinase activities has been shown to converge on the energetic organelle, the mitochondria. In this review, we highlight examples of selected major kinases which impact mitochondrial signaling. Further, we discuss pharmacological strategies to target kinase activities which are linked to cancer progression and redirecting mitochondrial function. Finally, we propose that cell-based recordings of mitochondrial bioenergetic states might predict off-target or identify specific on-target effects of kinase inhibitors.

• Keywords: Kinases, signaling, mitochondria, kinase inhibitors, cancer, drug off-target effects

• O2k-Network Lab: AT Innsbruck Oroboros

Affiliations

Torres-Quesada O^1,2, Strich S¹, Stefan E^1,2

1. Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria - [email protected]
2. Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria

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Labels: MiParea: Pharmacology;toxicology  Pathology: Cancer 

Organism: Human 

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