Thoral 2021 Biol Lett: Difference between revisions
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|title=Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759. | |title=Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/33563134 PMID: 33563134 Open Access] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/33563134 PMID: 33563134 Open Access] | ||
|authors=Thoral | |authors=Thoral Elisa, Roussel Damien, Chinopoulos Christos, Teulier Loic, Salin Karine | ||
|year=2021 | |year=2021 | ||
|journal=Biol Lett | |journal=Biol Lett | ||
|abstract=Aerobic metabolism of aquatic ectotherms is highly sensitive to fluctuating climates. Many mitochondrial traits exhibit phenotypic plasticity in response to acute variations in temperature and oxygen availability. These responses are critical for understanding the effects of environmental variations on aquatic ectotherms' performance. Using the European seabass, Dicentrarchus labrax, we determined the effects of acute warming and deoxygenation in vitro on mitochondrial respiratory capacities and mitochondrial efficiency to produce ATP (ATP/O ratio). We show that acute warming reduced ATP/O ratio but deoxygenation marginally raised ATP/O ratio, leading to a compensatory effect of low oxygen availability on mitochondrial ATP/O ratio at high temperature. The acute effect of warming and deoxygenation on mitochondrial efficiency might be related to the leak of protons across the mitochondrial inner membrane, as the mitochondrial respiration required to counteract the proton leak increased with warming and decreased with deoxygenation. Our study underlines the importance of integrating the combined effects of temperature and oxygen availability on mitochondrial metabolism. Predictions on decline in performance of aquatic ectotherms owing to climate change may not be accurate, since these predictions typically look at respiratory capacity and ignore efficiency of ATP production. | |abstract=Aerobic metabolism of aquatic ectotherms is highly sensitive to fluctuating climates. Many mitochondrial traits exhibit phenotypic plasticity in response to acute variations in temperature and oxygen availability. These responses are critical for understanding the effects of environmental variations on aquatic ectotherms' performance. Using the European seabass, ''Dicentrarchus labrax'', we determined the effects of acute warming and deoxygenation ''in vitro'' on mitochondrial respiratory capacities and mitochondrial efficiency to produce ATP (ATP/O ratio). We show that acute warming reduced ATP/O ratio but deoxygenation marginally raised ATP/O ratio, leading to a compensatory effect of low oxygen availability on mitochondrial ATP/O ratio at high temperature. The acute effect of warming and deoxygenation on mitochondrial efficiency might be related to the leak of protons across the mitochondrial inner membrane, as the mitochondrial respiration required to counteract the proton leak increased with warming and decreased with deoxygenation. Our study underlines the importance of integrating the combined effects of temperature and oxygen availability on mitochondrial metabolism. Predictions on decline in performance of aquatic ectotherms owing to climate change may not be accurate, since these predictions typically look at respiratory capacity and ignore efficiency of ATP production. | ||
|keywords=ATP/O ratio, Dissolved oxygen, Mitochondrial respiratory capacities, Temperature | |keywords=ATP/O ratio, Dissolved oxygen, Mitochondrial respiratory capacities, Temperature | ||
|editor=[[Plangger M]] | |editor=[[Plangger M]] | ||
|mipnetlab=HU Budapest Chinopoulos C, FR Plouzane Salin K | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration | |area=Respiration, Comparative MiP;environmental MiP | ||
|instruments=Oxygraph-2k | |organism=Fishes | ||
|additional=2021-01 | |tissues=Skeletal muscle | ||
|preparations=Homogenate | |||
|topics=Temperature | |||
|couplingstates=LEAK, OXPHOS | |||
|pathways=N, CIV, NS, ROX | |||
|instruments=Oxygraph-2k, O2k-Fluorometer | |||
|additional=2021-01, MgG | |||
}} | }} |
Latest revision as of 21:14, 19 February 2021
Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759. |
Thoral Elisa, Roussel Damien, Chinopoulos Christos, Teulier Loic, Salin Karine (2021) Biol Lett
Abstract: Aerobic metabolism of aquatic ectotherms is highly sensitive to fluctuating climates. Many mitochondrial traits exhibit phenotypic plasticity in response to acute variations in temperature and oxygen availability. These responses are critical for understanding the effects of environmental variations on aquatic ectotherms' performance. Using the European seabass, Dicentrarchus labrax, we determined the effects of acute warming and deoxygenation in vitro on mitochondrial respiratory capacities and mitochondrial efficiency to produce ATP (ATP/O ratio). We show that acute warming reduced ATP/O ratio but deoxygenation marginally raised ATP/O ratio, leading to a compensatory effect of low oxygen availability on mitochondrial ATP/O ratio at high temperature. The acute effect of warming and deoxygenation on mitochondrial efficiency might be related to the leak of protons across the mitochondrial inner membrane, as the mitochondrial respiration required to counteract the proton leak increased with warming and decreased with deoxygenation. Our study underlines the importance of integrating the combined effects of temperature and oxygen availability on mitochondrial metabolism. Predictions on decline in performance of aquatic ectotherms owing to climate change may not be accurate, since these predictions typically look at respiratory capacity and ignore efficiency of ATP production. โข Keywords: ATP/O ratio, Dissolved oxygen, Mitochondrial respiratory capacities, Temperature โข Bioblast editor: Plangger M โข O2k-Network Lab: HU Budapest Chinopoulos C, FR Plouzane Salin K
Labels: MiParea: Respiration, Comparative MiP;environmental MiP
Organism: Fishes
Tissue;cell: Skeletal muscle
Preparation: Homogenate
Regulation: Temperature Coupling state: LEAK, OXPHOS Pathway: N, CIV, NS, ROX HRR: Oxygraph-2k, O2k-Fluorometer
2021-01, MgG