Template:Current week ecosystem agenda: Difference between revisions

Revision as of 09:18, 1 March 2021

2021 Week 9

Mar-1 Mo

Complex I of the mitochondrial electron transfer system is an important druggable target in Alzheimer's disease

from the O2k-Network »US NY New York Galkin A«

Stojakovic A, Trushin S, Sheu A, Khalili L, Chang SY, Li X, Christensen T, Salisbury JL, Geroux RE, Gateno B, Flannery PJ, Dehankar M, Funk CC, Wilkins J, Stepanova A, O'Hagan T, Galkin A, Nesbitt J, Zhu X, Tripathi U, Macura S, Tchkonia T, Pirtskhalava T, Kirkland JL, Kudgus RA, Schoon RA, Reid JM, Yamazaki Y, Kanekiyo T, Zhang S, Nemutlu E, Dzeja P, Jaspersen A, Kwon YIC, Lee MK, Trushina E (2021) Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Commun Biol 4:61. »Bioblast link«

Mar-2 Tu

Measuring fatty acid oxidation (FAO)-linked respiration requires a low concentration of malate

In the absence of malate, accumulation of Acetyl-CoA inhibits FAO.
- »Fatty acid oxidation pathway control state«, »Mitochondrial Pathways: Chapter 5«
- communicated by »Cecatto Cristiane« and »Cardoso Luiza«

Mar-3 We

»FAT4BRAIN O2k-Workshop IOC148 Virtual Event« (Mar 3-4)

Mar-4 Th

Mar-05 Fr

@@ Line 1: / Line 1: @@
+Week 9
-Week 8
-*'''Feb-22 Mo'''
+*'''Mar-1 Mo'''
-:{|
-| width="100" align="center" |[[File:MitoFit Preprints pdf.png|100px|link=https://www.mitofit.org/index.php/Komlodi_2021_MitoFit_Q |MitoFit pdf]]
-|'''Exploring the Q-junction in real-time'''<br>
-Simultaneous measurement of coenzyme Q redox state and respiration in isolated mitochondria:<br>
-* Komlodi T, Cardoso LHD, Doerrier C, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. MitoFit Preprints 2021.2. [https://www.mitofit.org/index.php/Komlodi_2021_MitoFit_Q doi:10.26124/mitofit:2021-0002]
-|}
-----
-*'''Feb-23 Tu''' - [[12th_%C3%96GMBT_Annual_Meeting_2020_Virtual_Event#Programme|ÖGMBT Life Science Tuesdays]]
-----
-*'''Feb-24 We'''
 :{|
 | width="100" align="center" |[[Image:O2k-Publications.jpg|70px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]]
-|'''Anticancer effect of metformin in myeloproliferative neoplasms: downregulation of JAK2/STAT signaling and mitochondrial activity '''<br>
+|'''Complex I of the mitochondrial electron transfer system is an important druggable target in Alzheimer's disease'''<br>
-:from the O2k-Network »[[BR Ribeirao Preto Alberici LC]]«
+:from the O2k-Network »[[US NY New York Galkin A]]«
-*Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, Simões BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F (2018) Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. Cell Death Dis 9:311. [[Machado-Neto 2018 Cell Death Dis|»Bioblast link«]]
+*Stojakovic A, Trushin S, Sheu A, Khalili L, Chang SY, Li X, Christensen T, Salisbury JL, Geroux RE, Gateno B, Flannery PJ, Dehankar M, Funk CC, Wilkins J, Stepanova A, O'Hagan T, Galkin A, Nesbitt J, Zhu X, Tripathi U, Macura S, Tchkonia T, Pirtskhalava T, Kirkland JL, Kudgus RA, Schoon RA, Reid JM, Yamazaki Y, Kanekiyo T, Zhang S, Nemutlu E, Dzeja P, Jaspersen A, Kwon YIC, Lee MK, Trushina E (2021) Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Commun Biol 4:61. [[Stojakovic 2021 Commun Biol|»Bioblast link«]]
 |}
 ----
-*'''Feb-25 Th'''
+*'''Mar-2 Tu'''
 :{|
-| width="100" align="center" |[[File:MitoFit Preprints pdf.png|100px|link=https://www.mitofit.org/index.php/Zuccolotto-dos-Reis_2021_MitoFit_ACoAR |MitoFit pdf]]
+| width="110" align="center" | [[File:MitoPedia.jpg|left|80px|MitoPedia|link=MitoPedia]]
-|'''Diagnosis of mitochondrial disease in frozen samples '''<br>
+|''' Measuring fatty acid oxidation (FAO)-linked respiration requires a low concentration of malate '''<br>
-Measurement of respiratory function in cryopreserved muscle biopsies:<br>
+In the absence of malate, accumulation of Acetyl-CoA inhibits FAO. <br>
-Zuccolotto-dos-Reis FH, Andriao-Escarso SH, Araujo JS, Espreafico EM, Alberici LC, Sobreira CFR (2021) Acetyl CoA driven respiration in frozen muscle contributes to the diagnosis of mitochondrial disease. MitoFit Preprints 2021.3. [https://www.mitofit.org/index.php/Zuccolotto-dos-Reis_2021_MitoFit_ACoAR doi:10.26124/mitofit:2021-0003]
+- »'''[[Fatty acid oxidation pathway control state]]'''«, »'''[https://www.bioblast.at/index.php/Gnaiger_2020_BEC_MitoPathways Mitochondrial Pathways: Chapter 5]'''« <br>
+- communicated by »[[Cecatto Cristiane]]« and »[[Cardoso Luiza]]«
 |}
 ----
-*'''Feb-26 Fr'''
+*'''Mar-3 We'''
+:::: [[File:FAT4BRAIN logo.png|100px|FAT4BRAIN|link=FAT4BRAIN O2k-Workshop IOC148 Virtual Event]] <big>»'''[[FAT4BRAIN O2k-Workshop IOC148 Virtual Event]]'''«</big> (Mar 3-4)
 ----
-*'''Feb-27 Sa'''
+*'''Mar-4 Th'''
 ----
-*'''Feb-28 Su''' Rare disease day
+*'''Mar-05 Fr'''
-:{|
-| width="100" align="center" |[[Image:O2k-Publications.jpg|70px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]]
-|''' Wolframin deficiency-related changes in the bioenergetics of mouse muscle '''<br>
-:from the O2k-Network »[[EE Tallinn Kaambre T]]« »[[EE Tartu Paju K]]«
-*Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523. [[Tepp 2020 Biochim Biophys Acta Gen Subj|»Bioblast link«]]
-|}