Search results

• Lancaster 2002 Biochim Biophys Acta
  ....3.5.1) are enzymes that couple the two-electron oxidation of succinate to fumarate (reaction 1) to the two-electron reduction of quinone to quinol (reaction 2 succinate → fumarate + 2H⁺ + 2e^- (1)
  1 KB (167 words) - 19:20, 15 October 2023
• Fumarase
  ...[[tricarboxylic acid cycle]] catalyzing the equilibrium reaction between [[fumarate]] and [[malate]]. Fumarase is found not only in mitochondria, but also in t
  675 bytes (91 words) - 11:05, 27 January 2017
• Complex II
  ...ate reductases, FRDABCD) tend to operate in the reverse direction reducing fumarate and oxidizing quinol.
  2 KB (211 words) - 14:43, 1 April 2023
• Lancaster 2001 FEBS Lett
  ...oxidoreductases--what can we learn from ''Wolinella'' succinogenes quinol:fumarate reductase?. FEBS Lett 504:133-41. https://doi.org/10.1016/s0014-5793(01)027 ...the results from site-directed mutagenesis, we have derived a mechanism of fumarate reduction and succinate oxidation [Lancaster et al. (2001) Eur. J. Biochem.
  2 KB (287 words) - 19:21, 15 October 2023
• Wilson 1970 Biochim Biophys Acta
  |title=Wilson MA, Cascarano J (1970) The energy-yielding oxidation of NADH by fumarate in submitochondrial particles of rat tissues. Biochim Biophys Acta 216:54-6 |abstract=1. Oxidation of NADH by fumarate coupled to synthesis of ATP was found to occur in cyanide-poisoned rat hear
  2 KB (218 words) - 10:56, 14 February 2022
• Spinelli 2021 Science
  ...A, Condon KJ, Zhang T, Kunchok T, Lewis CA, Chandel NS, Sabatini DM (2021) Fumarate is a terminal electron acceptor in the mammalian electron transport chain. ...and complex I activities. Mouse tissues display varying capacities to use fumarate as a TEA, most of which net reverse the SDH complex under hypoxia. Thus, we
  2 KB (224 words) - 09:03, 2 April 2023
• Iverson 2013 Biochim Biophys Acta
  ...istinct chemical reactions: the reversible oxidoreduction of succinate and fumarate, catalyzed in a soluble domain, and the reversible oxidoreduction of quinol ...re kinetically advantaged to catalyze the reverse reaction, i.e. to reduce fumarate and oxidize quinol . No matter the preferred direction of the reaction, com
  3 KB (362 words) - 15:41, 1 April 2023
• Sullivan 2014 Cell Cycle
  ...oss of FH function are respiratory-deficient and accumulate high levels of fumarate. This raises an intriguing question: how do cancer cells with dysfunctional
  1 KB (171 words) - 07:18, 24 April 2023
• Brown 2000 Biochem Educ
  ...te:ubiquinone oxidoreductase (SQR) catalyses the oxidation of succinate to fumarate and the reductionof ubiquinone (UQ) to ubiquinol (UQH₂), .. ...by SDH/SQR, which is frequently written something like succinate + FAD <-> fumarate + FADH₂ [9-18]. This presentation implies that FAD is the final
  2 KB (299 words) - 16:26, 27 August 2023
• Chinopoulos 2019 Int J Biochem Cell Biol
  ...nally, it is emphasized that a "fumarate reductase" enzyme entity reducing fumarate to succinate found in some bacteria and lower eukaryotes remains to be disc
  2 KB (253 words) - 12:57, 2 August 2023
• Krebs, Eggleston 1940 Biochem J
  ...e catalysis when one molecule of pyruvate has reacted with one molecule of fumarate. ...ub>2</sub> uptake caused by fumarate to be proportional to the quantity of fumarate added. - ''Comment: Excess [[additivity]] at low malonate, and complete add
  4 KB (541 words) - 05:36, 18 July 2023
• Maklashina 2022 J Biol Chem
  ...ncing covalent flavinylation in both bacterial succinate dehydrogenase and fumarate reductase flavoprotein subunits and of SDHAF2 in performing the same functi
  2 KB (293 words) - 23:56, 2 April 2023
• Sridharan 2008 Am J Physiol Cell Physiol
  ...mping of O₂ respiration, reduced ATP utilization, and inducible fumarate respiration. Am J Physiol Cell Physiol 295:C29-37. doi: 10.1152/ajpcell.004 ...ATP consumption. The PHD pathway also enables the mitochondria to utilize fumarate for respiration.
  3 KB (357 words) - 23:36, 13 February 2022
• Mandella 1975 J Biol Chem
  ..., 0.06, and 0.09 mM, respectively. At pH 7.4 (5MM fumarate) and pH 6.0 (no fumarate), the Km values for (-)-malate, NADP+, and Mn2+ were 6.5, 0.62, and 0.59 mM
  3 KB (443 words) - 13:50, 27 February 2015
• Karavaeva 2023 Biochim Biophys Acta Bioenerg
  ...d fumarate reductases (FRDs) catalyse the interconversion of succinate and fumarate, a reaction highly conserved in all domains of life. The current classifica
  1 KB (209 words) - 21:11, 12 May 2023
• Fermentation
  ...aintained with internally produced electron acceptors (such as pyruvate or fumarate), without the use of external electron acceptors (such as O₂). F
  556 bytes (73 words) - 14:40, 8 February 2016
• Benit 2014 Biochim Biophys Acta
  ...-Roqueplo AP, Rustin P (2014) Unsuspected task for an old team: succinate, fumarate and other Krebs cycle acids in metabolic remodeling. Biochim Biophys Acta 1 ...s, key functions of several of its intermediates, especially succinate and fumarate, have been recently uncovered. The presumably immutable organization of the
  1 KB (217 words) - 17:28, 15 February 2022
• Andrieux 2021 Int J Mol Sci
  ...ction of FAD to FADH₂ to be linked to oxidation of succinate to fumarate. Perhaps open instead of anonymous peer review might encourage a scientific
  3 KB (390 words) - 02:35, 10 October 2023
• Malate dehydrogenase
  ...alized in the mitochondrial matrix and oxidizes [[malate]], generated from fumarate by fumarase, to [[oxaloacetate]], reducing NAD⁺ to NADH+H<sup>+<
  649 bytes (83 words) - 19:36, 1 January 2021
• Succinate dehydrogenase
  ...e dehydrogenase''' is a [[TCA cycle]] enzyme converting [[succinate]] to [[fumarate]] while reducing FAD to FADH₂. SDH is the largest component of t
  634 bytes (86 words) - 18:32, 15 May 2021
• Deschauer 2006 Mol Genet Metab
  ...ic investigation of fibroblasts showed only modest changes indicating that fumarate mediated inhibition of enzymatic pathways other than oxidative phosphorylat
  2 KB (306 words) - 15:19, 20 November 2018
• Sauer 1978 Cancer Res
  ...marate and inhibited by adenosine 5'-triphosphate. In the presence of 5 mM fumarate, the apparent Km values for malate were about 2 mM with either NAD+ or NADP
  2 KB (325 words) - 10:56, 26 February 2015
• Kumar 2021 J Biol Chem
  ...ions, the purine nucleotide cycle and the malate aspartate shuttle furnish fumarate, which supports complex II reversal and leads to succinate accumulation. Co |keywords=SDHA, Coenzyme Q, Complex II, Electron transport chain, Fumarate, Hydrogen sulfide
  2 KB (358 words) - 23:32, 23 April 2023
• Phosphoenolpyruvate carboxykinase
  ...pyruvate catalyzed by [[malic enzyme]] in the oxidative direction, and to fumarate in the reductive direction, leading to formation of succinate and ATP under
  1 KB (135 words) - 20:44, 30 April 2022
• Bastos Sant'Anna Silva 2018 Life Sciences Meeting 2018 Innsbruck AT
  ...t the inner mitochondrial membrane, coupling the oxidation of succinate to fumarate in the tricarboxylic acid cycle (TCA) with electron transfer to ubiquinone.
  3 KB (396 words) - 19:04, 10 January 2022
• Urban 1969 Eur J Biochem
  ...submitochondrial particles is measured by equilibration with the succinate/fumarate system to about 65 mV at pH 7, with the redox ratio, ''n'' = 2. The pH depe
  1 KB (151 words) - 22:48, 16 February 2021
• Goetzman 2023 Antioxidants (Basel)
  ...layer in the aging process. Mitochondrial Complex II converts succinate to fumarate and plays an essential role in both the tricarboxylic acid (TCA) cycle and
  1 KB (197 words) - 09:45, 22 October 2023
• Kita 2002 Biochim Biophys Acta
  ...robic energy metabolism of parasites inhabiting hosts, by acting as quinol-fumarate reductase.
  2 KB (230 words) - 13:16, 14 March 2022
• Chance 1961 J Biol Chem-III
  ...specific inhibitory responses of the reaction to malonate, phosphate, and fumarate.
  2 KB (210 words) - 10:45, 6 July 2022
• Bellance 2009 Front Biosci (Landmark Ed)
  ...sion in cancer cells. In particular, pyruvate, oxaloacetate, succinate and fumarate, four mitochondrial metabolites, activate genes relevant for tumor progress
  2 KB (235 words) - 01:41, 10 November 2023
• Piel 2023 MiP2023
  |title=[[File:PielS.jpg|left|100px|Piel Sarah]] Effect of dimethyl fumarate on cerebral mitochondrial metabolism in a porcine model of pediatric in-hos ...oor neurological outcome [5-6]. Here, we tested the potential of dimethyl fumarate (DMF), a derivative of the TCA-cycle intermediate fumaric acid shown to enh
  6 KB (837 words) - 16:37, 12 July 2023
• Vercellino 2022 Nat Rev Mol Cell Biol
  ::::* Complex II couples the oxidation of succinate to fumarate (in the Krebs cycle) with the reduction of ubiquinone to ubiquinol, .. Comp ...volves oxidation of succinate (C₄H₆O₄) to fumarate (C₄H₄O₄) in the SDHA subunit: the covalent
  4 KB (662 words) - 19:47, 6 November 2023
• Zoccarato 2011 J Bioenerg Biomembr
  ...e report that TCA cycle metabolites (citrate, isocitrate, α-ketoglutarate, fumarate, malate) individually and quickly inhibit H(2)O(2) release. When they are p
  2 KB (206 words) - 10:46, 3 April 2022
• Yin 2021 FASEB J
  ...t (RET) in inflammatory macrophages and is also responsible for regulating fumarate levels linking to epigenetic changes. Complex III also produces ROS which a
  2 KB (241 words) - 17:46, 5 October 2023
• Ishii 2012 Front Oncol
  ...cells are currently under extensive investigation. PP suppressed the NADH-fumarate reductase system that mediates a reverse reaction of the mitochondrial elec
  2 KB (244 words) - 04:00, 11 November 2023
• Fogg 2011 Chin J Cancer
  .... Mutations in specific metabolic enzymes, namely succinate dehydrogenase, fumarate hydratase and the isocitrate dehydrogenases, have been linked to human canc
  2 KB (277 words) - 11:28, 27 August 2023
• Glutamate-anaplerotic pathway control state
  ...in the [[GM-pathway control state]] (GM_''P''). Accumulation of fumarate inhibits succinate dehydrogenase and glutamate dehydrogenase.
  2 KB (276 words) - 20:11, 1 January 2021
• Wahrheit 2015 Eng Life Sci
  ...ADP supply. In contrast, the metabolization of α-ketoglutarate, succinate, fumarate, and malate was little controlled by the energy and redox state. Metaboliza
  2 KB (282 words) - 16:57, 7 November 2016
• Sanchez-de-Diego 2021 Redox Biol
  ...st numbers with marked sexual dimorphism. Finally, treatment with dimethyl fumarate prevented the deleterious effects of ovariectomy in trabecular bone masses
  2 KB (266 words) - 13:12, 19 July 2021
• Bundgaard 2019 Sci Rep
  ...and ischemic mouse hearts. However, succinate concentrations and succinate/fumarate ratios were lower in turtle than in mouse heart, limiting the driving force
  2 KB (303 words) - 21:36, 13 February 2022
• Hanna 2023 Antioxid Redox Signal
  ...ibitor have led to the exciting discovery of ETC plasticity and the use of fumarate as a terminal electron acceptor. H2S oxidation combined with complex IV tar
  2 KB (324 words) - 23:26, 23 April 2023
• Rasheed 2018 Arch Pathol Lab Med
  ...synthetase (SCS) to succinate. SDHA oversees the oxidation of succinate to fumarate in the citric acid cycle, resulting in the reduction of FAD to FADH2.6 SDHA
  2 KB (308 words) - 18:28, 1 April 2023
• Malinska 2010 Biochim Biophys Acta
  succinate/fumarate redox couple confirmed for brain tissue a bell-shapeddependencywith amaxima
  2 KB (296 words) - 16:43, 19 March 2015
• Singer 1956 J Biol Chem
  ...at 38 °C and 5.2 X 10-4 M at 21 °C. Oxalacetate, malonate, and fumarate are competitive inhibitors. Antimycin A and BAL do not inhibit t
  2 KB (311 words) - 10:46, 6 July 2022
• Saraiva 2022 Pathogens
  ...hypoxic condition also increased the expression of the hexokinase and NADH fumarate reductase genes and reduced NAD(P)H, suggesting that this increase in ATP l
  2 KB (311 words) - 13:27, 22 November 2022
• Bandara 2021 BMC Mol Cell Biol
  ...ays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the mitochondrial Krebs cycle and transferring electrons from succinate
  2 KB (353 words) - 16:06, 17 April 2023
• Jaramillo-Jimenez 2023 Mitochondrion
  ...correlation between pyruvate - succinate and positive correlations between fumarate - malate and citrate - Isocitrate in both LBD and AD. In the total sample,
  2 KB (334 words) - 16:40, 13 October 2023
• Wu 2022 Antioxidants (Basel)
  ...with those of known Nrf2 activators, omaveloxolone (RTA-408) and dimethyl fumarate (DMF), using human neuroblastoma SK-N-SH cells with stable transfection of
  2 KB (310 words) - 16:05, 31 August 2022
• Hand 1990 J Comp Physiol B
  ...c peak that accumulated under anoxia has not been successfully identified. Fumarate and pyruvate levels decreased as anoxia proceeded. Thus, a perceptible ener
  3 KB (351 words) - 09:41, 9 November 2016
• Rosca 2012 Diabetes
  :::: '''Fig. 5''' of Rosca et al (2012): Oxidation of succinate to fumarate reduces ubiquinone to ubiquinol through oxidation of FAD to FADH<sub>2</sub
  3 KB (404 words) - 20:01, 4 November 2023

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