ROUTINE respiration: Difference between revisions
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|abbr=''R'' | |abbr=''R'' | ||
|description=In the intact cell, '''ROUTINE respiration''' in the physiological coupling [[State R|state ''R'']], is controlled by cellular energy demand, energy turnover and the degree of coupling to phosphorylation (intrinsic [[uncoupling]] and pathological [[dyscoupling]]). ''R'' and growth of cells is supported by exogenous substrates in culture media. In media without energy substrates, ''R'' depends on endogenous substrates. ''R'' cannot be measured in [[permeabilized cells]] or [[isolated mitochondria]]. | |description=In the intact cell, '''ROUTINE respiration''' in the physiological coupling [[State R|state ''R'']], is controlled by cellular energy demand, energy turnover and the degree of coupling to phosphorylation (intrinsic [[uncoupling]] and pathological [[dyscoupling]]). ''R'' and growth of cells is supported by exogenous substrates in culture media. In media without energy substrates, ''R'' depends on endogenous substrates. ''R'' cannot be measured in [[permeabilized cells]] or [[isolated mitochondria]]. | ||
|info=[[MiPNet12.15]], [[MiPNet08.09]], [[Gnaiger_2008_POS]] | |info=[http://www.oroboros.at/?Gnaiger_2012_MitoPathways Gnaiger 2012 MitoPathways][[MiPNet12.15]], [[MiPNet08.09]], [[Gnaiger_2008_POS]] | ||
|type=Respiration | |type=Respiration | ||
}} | }} |
Revision as of 18:12, 8 January 2013
Description
In the intact cell, ROUTINE respiration in the physiological coupling state R, is controlled by cellular energy demand, energy turnover and the degree of coupling to phosphorylation (intrinsic uncoupling and pathological dyscoupling). R and growth of cells is supported by exogenous substrates in culture media. In media without energy substrates, R depends on endogenous substrates. R cannot be measured in permeabilized cells or isolated mitochondria.
Abbreviation: R
Reference: Gnaiger 2012 MitoPathwaysMiPNet12.15, MiPNet08.09, Gnaiger_2008_POS
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Why not 'basal respiration', and what about 'State 3.5'?
Basal respiration or "basal metabolic rate" is frequently used in the context of isolated mitochondria as LEAK respiration (State 4). Importantly, we have to make a clear distinction between (oligomycin-inhibited) LEAK respiration and physiologically controlled ROUTINE respiration, none of which conform to the physiological definition of basal respiration.