Difference between revisions of "Q-junction"
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::* '''Coupling control state ''E''''' | ::* '''Coupling control state ''E''''' | ||
::::[[File:E.jpg |link=ET | ::::[[File:E.jpg |link=ET capacity]] [[ET capacity]] | ||
::::» [[Noncoupled respiration]] | ::::» [[Noncoupled respiration]] | ||
::::» [[Uncoupler#Is_respiration_uncoupled_-_noncoupled_-_dyscoupled.3F |Is respiration uncoupled - noncoupled - dyscoupled?]] | ::::» [[Uncoupler#Is_respiration_uncoupled_-_noncoupled_-_dyscoupled.3F |Is respiration uncoupled - noncoupled - dyscoupled?]] |
Revision as of 15:22, 8 June 2020
Description
The Q-junction is a junction for convergent electron flow in the Electron transfer pathway (ET-pathway) from type N substrates and mt-matix dehydrogenases through Complex I (CI), from type F substrates and FA oxidation through electron-transferring flavoprotein complex (CETF), from succinate (S) through Complex II (CII), from glycerophosphate (Gp) through glycerophosphate dehydrogenase complex (CGpDH), from choline through choline dehydrogenase, from dihydro-orotate through dihydro-orotate dehydrogenase, and other enzyme complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to Complex III (CIII) and Complex IV (CIV). The concept of the Q-junction, with the N-junction and F-junction upstream, provides the rationale for defining Electron-transfer-pathway states and categories of SUIT protocols.
Reference: Gnaiger 2009 Int J Biochem Cell Biol, Gnaiger 2014 MitoPathways
MitoPedia concepts:
MiP concept,
SUIT concept
MitoPedia methods:
Respirometry
MitoPedia topics:
Enzyme
Contributed by Gnaiger E 2010-08-15; edited 2016-02-12, 2016-03-28.
- Convergent NS-linked electron flow at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: Gnaiger 2009; lower panel: Hatefi 1962 J Biol Chem-XLII). Modified Fig. 1.5 in Gnaiger 2014 MitoPathways.
- » Keywords
- Specific
- General
- » Categories of SUIT protocols
- » Choline dehydrogenase
- » Complex I
- » Complex II
- » Dihydro-orotate dehydrogenase
- » Electron-transferring flavoprotein complex
- » Electron transfer pathway
- » F-junction
- » Glycerophosphate dehydrogenase complex
- » N-junction
- » NS-linked electron flow
- » Electron-transfer-pathway states
- General
Related MitoPedia pages
- Electron transfer pathway, ET-pathway
- Electron-transfer-pathway state
- Coupling control state E
SUITbrowser question: Q-junction
- Several SUIT protocols can be used to answer questions on additivity, or convergence of electron flow to the Q-junction.
- The SUITbrowser can be used to find the best SUIT protocols for different research questions, among those: