MitoKit-CII: Difference between revisions
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{{Product | {{Product | ||
|description=Cell permeable compound - MitoKit-CII, 2 vials; 1 vial of plasma membrane-permeable succinate (NV118; 25 mg) and 1 vial of plasma membrane-permeable malonate (NV161; 10 mg). | |description=Cell permeable compound - MitoKit-CII, 2 vials; 1 vial of plasma membrane-permeable succinate-nv (Snv; NV118; 25 mg) and 1 vial of plasma membrane-permeable malonate-nv (Mnanv; NV161; 10 mg). | ||
|product id=60200-01 | |product id=60200-01 | ||
|product type=O2k | |product type=O2k | ||
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== Compounds of MitoKit-CII == | == Compounds of MitoKit-CII == | ||
:::: The MitoKit-CII consists of the first generation of NeuroVive Pharmaceutical AB's cell permeable succinate and malonate prodrugs. | :::: The MitoKit-CII consists of the first generation of NeuroVive Pharmaceutical AB's cell permeable succinate and malonate prodrugs. The MitoKit-CII was developed to stimulate (succinate-nv) or inhibit (malonate-nv) the Complex II of the respiratory electron transfer system in living cells, and will expand the toolbox for evaluating the role of mitochondria in disease. | ||
:::: The MitoKit-CII is composed of the following compounds: | :::: The MitoKit-CII is composed of the following compounds: | ||
::::* '''Cell permeable compound [[ | ::::* '''Cell permeable compound [[MitoKit-CII/Succinate-nv]]''', Snv | ||
::::: Description: Succinate prodrug: C<sub>10</sub>H<sub>14</sub>O<sub>8</sub>, Molecular weight 262.2 g.mol<sup>-1</sup> | ::::: Description: Succinate prodrug: C<sub>10</sub>H<sub>14</sub>O<sub>8</sub>, Molecular weight 262.2 g.mol<sup>-1</sup> | ||
::::: Aliquots of 25 mg | ::::: Aliquots of 25 mg | ||
::::* '''Cell permeable compound [[ | ::::* '''Cell permeable compound [[MitoKit-CII/Malonate-nv]]''', Mnanv | ||
::::: Description: Malonate prodrug: C<sub>9</sub>H<sub>12</sub>O<sub>8</sub>, Molecular weight 248.2 g.mol<sup>-1</sup> | ::::: Description: Malonate prodrug: C<sub>9</sub>H<sub>12</sub>O<sub>8</sub>, Molecular weight 248.2 g.mol<sup>-1</sup> | ||
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::: CAS-Numbers | ::: CAS-Numbers | ||
::::* | ::::* MitoKit-CII/Succinate-nv: 1592635-33-0 Β | ||
::::* | ::::* MitoKit-CII/Malonate-nv: 1432752-62-9 Β | ||
Revision as of 17:00, 3 June 2019
MitoKit-CII
Description | Cell permeable compound - MitoKit-CII, 2 vials; 1 vial of plasma membrane-permeable succinate-nv (Snv; NV118; 25 mg) and 1 vial of plasma membrane-permeable malonate-nv (Mnanv; NV161; 10 mg). |
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Product ID | 60200-01 |
Type | O2k |
Link | MitoKit-CII MitoPedia |
Image |
Compounds of MitoKit-CII
- The MitoKit-CII consists of the first generation of NeuroVive Pharmaceutical AB's cell permeable succinate and malonate prodrugs. The MitoKit-CII was developed to stimulate (succinate-nv) or inhibit (malonate-nv) the Complex II of the respiratory electron transfer system in living cells, and will expand the toolbox for evaluating the role of mitochondria in disease.
- The MitoKit-CII is composed of the following compounds:
- Cell permeable compound MitoKit-CII/Succinate-nv, Snv
- Description: Succinate prodrug: C10H14O8, Molecular weight 262.2 g.mol-1
- Aliquots of 25 mg
- Cell permeable compound MitoKit-CII/Malonate-nv, Mnanv
- Description: Malonate prodrug: C9H12O8, Molecular weight 248.2 g.mol-1
- Aliquots of 10 mg
- Reference
- Ehinger JK, Piel S, Ford R, Karlsson M, SjΓΆvall F, Frostner EΓ , Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, ElmΓ©r E (2016) Cell-permeable succinate prodrugs bypass mitochondrial Complex I deficiency. Nat Commun 7:12317. Β»Bioblast linkΒ« - Original publication introducing Mito-CII.
Expiry date of MitoKit-CII compounds (according to NeuroVive)
- Before preparation
- 3 years in -80Β° C
- 1 year in -20Β° C
- Before preparation
- Prepared
- In DMSO solution
- at room temperature: 24 h
- at -20 Β°C: for 6 months
- Prepared
- CAS-Numbers
- MitoKit-CII/Succinate-nv: 1592635-33-0
- MitoKit-CII/Malonate-nv: 1432752-62-9
- CAS-Numbers
Labels: MiParea: Instruments;methods
HRR: O2k-Protocol
O2k-chemicals and media