L/E coupling-control ratio: Difference between revisions
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|description=[[Image:L over E.jpg|50 px|LEAK control ratio]] The '''LEAK control ratio''', or ''L/E'' coupling control ratio [1,2], is the flux ratio of [[LEAK respiration]] over [[ETS capacity]], as determined by measurement of oxygen consumption in sequentially induced states ''L'' and ''E'' of respiration. The ETS control ratio is an index of [[uncoupling]] or [[dyscoupling]] at constant ETS capacity. ''L/E'' increases with uncoupling from a theoretical minimum of 0.0 for a fully coupled system, to 1.0 for a fully uncoupled system [3]. | |description=[[Image:L over E.jpg|50 px|LEAK control ratio]] The '''LEAK control ratio''', or ''L/E'' coupling control ratio [1,2], is the flux ratio of [[LEAK respiration]] over [[ETS capacity]], as determined by measurement of oxygen consumption in sequentially induced states ''L'' and ''E'' of respiration. The ETS control ratio is an index of [[uncoupling]] or [[dyscoupling]] at constant ETS capacity. ''L/E'' increases with uncoupling from a theoretical minimum of 0.0 for a fully coupled system, to 1.0 for a fully uncoupled system [3]. | ||
|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2014 MitoPathways]] | ||
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{{MitoPedia | {{MitoPedia O2k and high-resolution respirometry|type=Respiration | ||
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|type=Respiration | {{MitoPedia topics|type=Respiration | ||
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== Compare == | == Compare == | ||
Revision as of 13:43, 8 February 2016
- high-resolution terminology - matching measurements at high-resolution
L/E coupling-control ratio
Description
The LEAK control ratio, or L/E coupling control ratio [1,2], is the flux ratio of LEAK respiration over ETS capacity, as determined by measurement of oxygen consumption in sequentially induced states L and E of respiration. The ETS control ratio is an index of uncoupling or dyscoupling at constant ETS capacity. L/E increases with uncoupling from a theoretical minimum of 0.0 for a fully coupled system, to 1.0 for a fully uncoupled system [3].
Abbreviation: L/E
Reference: Gnaiger 2009 Int J Biochem Cell Biol, Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory control ratio
MitoPedia methods:
Respirometry
Compare
- » ETS coupling efficiency, j≈E = 1-L/E = ≈E/E
- » OXPHOS coupling efficiency, j≈P = 1-L/P = ≈P/P
- » ROUTINE coupling efficiency, j≈R = 1-L/R = ≈R/R
- » UCR = E/L
- » RCR = P/L
References
- Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41: 1837–1845.
- Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopisies of human muscle. Methods Mol Biol 810: 25-58.
- Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck: 80 pp.
