Bernardo 2013 Biol Chem: Difference between revisions
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Revision as of 22:05, 3 August 2023
Bernardo A, De Simone R, De Nuccio C, Visentin S, Minghetti L (2013) The nuclear receptor peroxisome proliferator-activated receptor-Ξ³ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves. Biol Chem 394:1607-14. doi: 10.1515/hsz-2013-0152 |
Bernardo A, De Simone R, De Nuccio C, Visentin S, Minghetti L (2013) Biol Chem
Abstract: Peroxisome proliferator-activated receptor-Ξ³ (PPAR-Ξ³) is one of the most studied nuclear receptor since its identification as a target to treat metabolic and neurological diseases. In addition to exerting anti-inflammatory and neuroprotective effects, PPAR-Ξ³ agonists, such as the insulin-sensitizing drug pioglitazone, promote the differentiation of oligodendrocytes (OLs), the myelin-forming cells of the central nervous system (CNS). In addition, PPAR-Ξ³ agonists increase OL mitochondrial respiratory chain activity and OL's ability to respond to environmental signals with oscillatory Ca2+ waves. Both OL maturation and oscillatory Ca2+ waves are prevented by the mitochondrial inhibitor rotenone and restored by PPAR-Ξ³ agonists, suggesting that PPAR-Ξ³ promotes myelination through mechanisms involving mitochondria.
β’ Bioblast editor: Gnaiger E
Correction: FADH2 and Complex II
- FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).
- Gnaiger E (2024) Complex II ambiguities β FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - Β»Bioblast linkΒ«
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Enzyme: Complex II;succinate dehydrogenase