Additive effect of convergent electron flow: Difference between revisions
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|abbr=''A'' | |abbr=''A'' | ||
|description=There is an '''additive effect''' on respiration by electron flow converging at the '''Q-junction''' from respiratory Complexes I and II ([[CI+II e-input]]), [[glycerophosphate dehydrogenase]] and [[electron-transferring flavoprotein]]. Convergent electron flow corresponds to the operation of the [[TCA cycle]] and mitochondrial substrate supply in vivo. Convergent electron flow simultaneously through CI+II into the [[Q-junction]] supports higher [[OXPHOS capacity]] and [[ETS capacity]] than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular [[TCA cycle]] function. The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with [[mt-preparations]] have underestimated cellular OXPHOS capacities, due to the gating effect through a single branch, corresponding to [[additivity]]. | |description=There is an '''additive effect''' on respiration by electron flow converging at the '''Q-junction''' from respiratory Complexes I and II ([[CI+II e-input]]), [[glycerophosphate dehydrogenase]] and [[electron-transferring flavoprotein]]. Convergent electron flow corresponds to the operation of the [[TCA cycle]] and mitochondrial substrate supply in vivo. Convergent electron flow simultaneously through CI+II into the [[Q-junction]] supports higher [[OXPHOS capacity]] and [[ETS capacity]] than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular [[TCA cycle]] function. The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with [[mt-preparations]] have underestimated cellular OXPHOS capacities, due to the gating effect through a single branch, corresponding to [[additivity]]. | ||
|info=[[MiPNet12.12]], [[ | |info=[[MiPNet12.12]], [[Gnaiger_2009_Int J Biochem Cell Biol]] | ||
|type=Respiration | |type=Respiration | ||
}} | }} | ||
Revision as of 18:39, 17 February 2012
- high-resolution terminology - matching measurements at high-resolution
Additive effect of convergent electron flow
Description
There is an additive effect on respiration by electron flow converging at the Q-junction from respiratory Complexes I and II (CI+II e-input), glycerophosphate dehydrogenase and electron-transferring flavoprotein. Convergent electron flow corresponds to the operation of the TCA cycle and mitochondrial substrate supply in vivo. Convergent electron flow simultaneously through CI+II into the Q-junction supports higher OXPHOS capacity and ETS capacity than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular TCA cycle function. The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with mt-preparations have underestimated cellular OXPHOS capacities, due to the gating effect through a single branch, corresponding to additivity.
Abbreviation: A
Reference: MiPNet12.12, Gnaiger_2009_Int J Biochem Cell Biol
MitoPedia methods:
Respirometry
