Viruses and mitochondrial medicine: Difference between revisions
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:::* <big>'''"And this global political crisis isn't over yet. It has barely begun."</big>''' | |||
:::: 2020-03-21: "Too few people paid attention to China's well documented clinical experience. The present outcome was all too plain to predict." - Richard Horton (2020) Offline: COVID-19—a reckoning. Lancet 10228: P935, March 21, 2020. - [https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30669-3/fulltext?dgcid=raven_jbs_etoc_email »Open Access«] | |||
:::* <big>'''Official H2020 position </big>''' | :::* <big>'''Official H2020 position </big>''' | ||
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:::: If such a situation occurs, beneficiaries must immediately inform the Commission/Agency/Funding Body, which will examine on a case-by-case basis the possible application of the rules on force majeure. Moreover, beneficiaries must immediately take all the necessary steps to limit any damage due to force majeure (e.g. try to cancel the flight ticket, claim the reimbursement from the cancellation insurance (if applicable)). | :::: If such a situation occurs, beneficiaries must immediately inform the Commission/Agency/Funding Body, which will examine on a case-by-case basis the possible application of the rules on force majeure. Moreover, beneficiaries must immediately take all the necessary steps to limit any damage due to force majeure (e.g. try to cancel the flight ticket, claim the reimbursement from the cancellation insurance (if applicable)). | ||
:::: Costs will be eligible, if they fulfil the general eligibility conditions set out in Article 6 H2020 MGA like any other costs incurred under the action. For example, if a meeting/event cannot take place due to force majeure, travel and accommodation costs may still be charged to the H2020 action if they fulfil the cost eligibility conditions, even if the beneficiary did not travel and did not take part in the meeting/event. If force majeure entails extra costs for the implementation of the action, these costs may be eligible if necessary for the implementation for the action (e.g. a cancelled conference is reorganised at a later stage). However, the maximum grant amount cannot be increased. | :::: Costs will be eligible, if they fulfil the general eligibility conditions set out in Article 6 H2020 MGA like any other costs incurred under the action. For example, if a meeting/event cannot take place due to force majeure, travel and accommodation costs may still be charged to the H2020 action if they fulfil the cost eligibility conditions, even if the beneficiary did not travel and did not take part in the meeting/event. If force majeure entails extra costs for the implementation of the action, these costs may be eligible if necessary for the implementation for the action (e.g. a cancelled conference is reorganised at a later stage). However, the maximum grant amount cannot be increased. | ||
Revision as of 18:56, 20 March 2020
- high-resolution terminology - matching measurements at high-resolution
Viruses and mitochondrial medicine
Description
Not enough is known about viruses and mitochondrial medicine, although several studies point towards a link between viral infection and mitochondrial dysfunction using high-resolution respirometry, with potential impact on drug development.
Abbreviation: Virus-mt-Medicine
Communicated by Gnaiger E 2020-02-23, last update 2020-03-20
- Let's talk COVID-19 - a new culture of communication in science. - Kay Kupferschmidt in Science
- »WHO Coronavirus disease (COVID-2019) situation reports«
- 2020-03-20 WHO Coronavirus disease 2019 (COVID-19) Situation Report – 59: "The number of confirmed cases worldwide has exceeded 200 000. It took over three months to reach the first 100 00 confirmed cases, and only 12 days to reach the next 100 000.
- 2020-03-11* WHO declares COVID-19 a pandemic - why so late? See »JAMA 2020-03-03«
- »WHO Coronavirus disease (COVID-2019) situation reports«
- "And this global political crisis isn't over yet. It has barely begun."
- 2020-03-21: "Too few people paid attention to China's well documented clinical experience. The present outcome was all too plain to predict." - Richard Horton (2020) Offline: COVID-19—a reckoning. Lancet 10228: P935, March 21, 2020. - »Open Access«
- Official H2020 position
- Published on : 16-03-2020 4:52 PM
- FAQ ID : 12945
- Article 51 of the H2020 MGA sets out the conditions in which the force majeure clause can be used. ‘Force majeure’ relates to an extraordinary and unforeseeable event or situation that is beyond the beneficiaries control and that prevents them from fulfilling their obligations under the action.
- If such a situation occurs, beneficiaries must immediately inform the Commission/Agency/Funding Body, which will examine on a case-by-case basis the possible application of the rules on force majeure. Moreover, beneficiaries must immediately take all the necessary steps to limit any damage due to force majeure (e.g. try to cancel the flight ticket, claim the reimbursement from the cancellation insurance (if applicable)).
- Costs will be eligible, if they fulfil the general eligibility conditions set out in Article 6 H2020 MGA like any other costs incurred under the action. For example, if a meeting/event cannot take place due to force majeure, travel and accommodation costs may still be charged to the H2020 action if they fulfil the cost eligibility conditions, even if the beneficiary did not travel and did not take part in the meeting/event. If force majeure entails extra costs for the implementation of the action, these costs may be eligible if necessary for the implementation for the action (e.g. a cancelled conference is reorganised at a later stage). However, the maximum grant amount cannot be increased.
- COST: European Cooperation in Science and Technology - Statements to the COVID-19
- From: Christophe Peeters <[email protected]>
- Sent: Friday, March 13, 2020 12:16
- To: Christophe Peeters <[email protected]>
- Subject: CORONAVIRUS - COST activities
- Importance: High
- Dear Grant Holders,
- Due to the evolving situation and uncertainty regarding the coronavirus (COVID-19) outbreak, we would like to update you concerning the actions put in place by the COST Association to deal with the outbreak of coronavirus and its consequences .
- Considering the measures made by most of the EU Member States and other States as of yesterday and the scope of those measures for our activities, the COST Association recommends the following measures, which will be enforced, as a minimum until 03 April:
- - The suspension of physical meetings occurring within the framework of COST activities
- - The cancellation of Training schools and STSMs
- To mitigate the disruption to your Action, the following measures are encouraged:
- - Video conferences
- - The continuation of networking tools, including dissemination tools, that do not require physical meetings
- Please instruct all your participants invited to meetings to:
- - cancel their transport tickets and accommodation ;
- - get reimbursement where possible via cancellation insurances or other available means. Otherwise non-refundable expenses will be covered by the grants of the COST Actions by requesting a derogation approval.
- - inform any participants currently attending events that they should follow the national and host institutions’ instructions.
- In practice, those measures mean the following:
- - Physical meetings’ suspension;
- - Video conferences are encouraged;
- - All networking tools, including dissemination tools, that do not require physical meeting should continue as much as possible;
- - Upcoming Training schools and STSMs should be cancelled;
- - STSMs and Training Schools currently taking place should follow the national and Host institutions’ instructions;
- - Participation in Conferences and external meetings should follow the instructions of the organisers.
- We understand the concern that this situation is creating amongst our community and we ask COST Actions Participants for patience in dealing with their claims arising out of those cancellations.
- Yours sincerely
- Christophe Peeters | Administrative Officer
- COST Association | Avenue Louise 149, 1050 Brussels | Belgium
- "Given the continual spread of COVID-19 around the world, understanding the action items that were implemented quickly in Taiwan and assessing the effectiveness of these actions in preventing a large-scale epidemic may be instructive for other countries." - Wang C Jason, Ng Chun Y, Brook Robert H (2020) Response to COVID-19 in Taiwan. Big data analytics, new technology, and proactive testing. JAMA. Published online March 3, 2020. - »Open Access«
- 2020-03-10 Corona virus - University of Innsbruck: beginning with March 10, no lectures will take place on the university premises
- »https://www.uibk.ac.at/newsroom/information-on-the-corona-virus.html.en«
- 2019-nCoV (WHO), SARS-CoV-2 (International Committee on Taxonomy of Viruses)
Publications: Viruses and mt-medicine
Year | Reference | Organism | Tissue;cell | Stress | |
---|---|---|---|---|---|
Brown 2020 BMJ | 2020 | Brown Robert A, Rhein Helga M, Alipio Mark M, Annweiler Cedric, Gnaiger Erich, Holick Michael F, Boucher Barbara J, Duque Gustavo, Féron François, Kenny Rose Anne, Montero-Odasso Manuel, Minisola Salvatore, Rhodes Jonathan, Haq Afrozul, Bejerot Susanne, Reiss Lina AJ, Zgaga Lina, Crawford Michael A, Fricker Rosemary A, Cobbold Peter, Lahore Henry W, Humble Mats B, Sarkar Amrita, Karras Spiros, Iglesias-Gonzalez Javier, Gezen-Ak Duygu, Dursun Erdinc, Cooper Isabella, Grimes David, de Voil Cedric WB (2020) COVID-19 ’ICU’ risk – 20-fold greater in the vitamin D deficient. BAME, African Americans, the older, institutionalised and obese, are at greatest risk. Sun and ‘D’-supplementation – game-changers? Research urgently required. https://doi.org/10.1136/bmj.m1548 | Human | Lung;gill Fat | |
Brown 2020 MitoFit Preprint Arch | 2020 | Brown RA, Sarkar A (2020) Vitamin D deficiency: a factor in COVID-19, progression, severity and mortality? – An urgent call for research. https://doi.org/10.26124/mitofit:200001 | Human | ||
Ledur 2020 Sci Rep | 2020 | Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218. | Human | Nervous system | |
Weinstein 2019 bioRxiv | 2019 | Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 . | Human | Other cell lines Lymphocyte | |
Du 2019 J Virol | 2019 | Du C, Duan Y, Wang XF, Lin Y, Na L, Wang X, Chen K, Wang X (2019) Attenuation of equine lentivirus alters mitochondrial protein expression profile from inflammation to apoptosis. J Virol 93:e00653-19. | Horse | Blood cells Other cell lines | Cell death |
Braz-De-Melo 2019 Sci Rep | 2019 | Braz-De-Melo HA, Pasquarelli-do-Nascimento G, Corrêa R, das Neves Almeida R, de Oliveira Santos I, Prado PS, Picolo V, de Bem AF, Pizato N, Magalhães KG (2019) Potential neuroprotective and anti-inflammatory effects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells. Sci Rep 9:20119. | Human | Neuroblastoma | |
Fernandes-Siqueira 2018 mSphere | 2018 | Fernandes-Siqueira LO, Zeidler JD, Sousa BG, Ferreira T, Da Poian AT (2018) Anaplerotic role of glucose in the oxidation of endogenous fatty acids during Dengue virus infection. mSphere 3.pii: e00458-17. | Human | Liver Other cell lines | |
Qu 2018 FASEB J | 2018 | Qu C, Zhang S, Wang W, Li M, Wang Y, van der Heijde-Mulder M, Shokrollahi E, Hakim MS, Raat NJH, Peppelenbosch MP, Pan Q (2018) Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target. FASEB J 33:1008-19. | Human | Liver | |
Wang 2018 Mol Med Rep | 2018 | Wang B, Li W, Fang H, Zhou H (2018) Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis. Mol Med Rep 19:320-26. https://doi.org/10.3892/mmr.2018.9619 | Human | Liver | |
Xia 2016 RSC Adv | 2016 | Xia Z, Yi X, Zhuang Y (2016) Stable over-expression of the human malate–aspartate NADH shuttle member Aralar I in PK15 cells improves energy metabolism and enhances proliferation of porcine circovirus-2. RSC Adv 6:61268-77. | Pig | Kidney | |
Silva 2012 PLOS ONE | 2012 | Silva da Costa L, Pereira da Silva AP, Da Poian AT, El-Bacha T (2012) Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis virus: implications to viral replication and neuronal death. PLoS One 7:e33871. | Mouse | Neuroblastoma | Mitochondrial disease |
El-Bacha 2012 Int J Biochem Cell Biol | 2012 | El-Bacha T, Da Poian AT (2012) Virus-induced changes in mitochondrial bioenergetics as potential targets for therapy. Int J Biochem Cell Biol 45:41-6. | Human Mouse | Nervous system Liver Fibroblast | Oxidative stress;RONS |
Morse 2012 J Infect Dis | 2012 | Morse CG, Voss JG, Rakocevic G, McLaughlin M, Vinton CL, Huber C, Hu X, Yang J, Huang da W, Logun C, Danner RL, Rangel ZG, Munson PJ, Orenstein JM, Rushing EJ, Lempicki RA, Dalakas MC, Kovacs JA (2012) HIV infection and antiretroviral therapy have divergent effects on mitochondria in adipose tissue. J Infect Dis 205:1778-1787. | Human | Skeletal muscle Blood cells Fat | |
Mutuel 2010 Virology | 2010 | Mutuel D, Ravallec M, Chabi B, Multeau C, Salmon JM, Fournier P, Ogliastro M (2010) Pathogenesis of Junonia coenia densovirus in Spodoptera frugiperda: a route of infection that leads to hypoxia. Virology 403:137-44. | Hexapods | Ischemia-reperfusion Oxidative stress;RONS | |
El-Bacha 2007 Biochim Biophys Acta | 2007 | El-Bacha T, Midlej V, Pereira da Silva AP, Silva da Costa L, Benchimol M, Galina A, Da Poian AT (2007) Mitochondrial and bioenergetic dysfunction in human hepatic cells infected with dengue 2 virus. Biochim Biophys Acta 1772:1158-66. | Human | Liver | Cell death |
Yuan 2006 Mol Cells | 2006 | Yuan X, Shan Y, Yao Z, Li J, Zhao Z, Chen J, Cong Y (2006) Mitochondrial location of severe acute respiratory syndrome coronavirus 3b protein. Mol Cells 21:186–91. | Human | Cell death | |
Vrbacky 2003 Physiol Res | 2003 | Vrbacký M, Krijt J, Drahota Z, Mĕlková Z (2003) Inhibitory effects of Bcl-2 on mitochondrial respiration. Physiol Res 52:545-54. | Human Other mammals | Endothelial;epithelial;mesothelial cell Other cell lines HeLa | Cell death |
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