Pierron 2012 Mitochondrion: Difference between revisions
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{{Publication | {{Publication | ||
|title=Pierron D, Letellier T, Grossman LI (2012) Mitogroup: continent-specific clusters of mitochondrial OXPHOS complexes based on nuclear non-synonymous polymorphisms. Mitochondrion 12: 237-241. | |title=Pierron D, Letellier T, Grossman LI (2012) Mitogroup: continent-specific clusters of mitochondrial OXPHOS complexes based on nuclear non-synonymous polymorphisms. Mitochondrion 12: 237-241. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/21968253 PMID: 21968253] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/21968253 PMID: 21968253] | ||
|authors=Pierron D, Letellier T, Grossman LI | |authors=Pierron D, Letellier T, Grossman LI | ||
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|abstract=OXPHOS polymorphisms are known to be population specific and to influence disease. Previous studies have focused on mtDNA polymorphisms. Based on a world sampling of 629 unrelated individuals, we have now studied the polymorphisms of the 80 genes encoding OXPHOS nuclear subunits. We have shown that (i) amino-acid replacement frequencies are significantly correlated with their pathogenicity probability, and (ii) populations can be distinguished based only on amino-acid replacements in nuclear encoded OXPHOS subunits. These results are congruent with the major mtDNA haplogroups, which suggests that OXPHOS complexes are different across the populations in both nuclear and in mitochondrial encoded subunits. | |abstract=OXPHOS polymorphisms are known to be population specific and to influence disease. Previous studies have focused on mtDNA polymorphisms. Based on a world sampling of 629 unrelated individuals, we have now studied the polymorphisms of the 80 genes encoding OXPHOS nuclear subunits. We have shown that (i) amino-acid replacement frequencies are significantly correlated with their pathogenicity probability, and (ii) populations can be distinguished based only on amino-acid replacements in nuclear encoded OXPHOS subunits. These results are congruent with the major mtDNA haplogroups, which suggests that OXPHOS complexes are different across the populations in both nuclear and in mitochondrial encoded subunits. | ||
|keywords=mtDNA haplogroups | |keywords=mtDNA haplogroups | ||
|mipnetlab=FR Bordeaux Letellier T | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
Latest revision as of 16:31, 26 March 2018
| Pierron D, Letellier T, Grossman LI (2012) Mitogroup: continent-specific clusters of mitochondrial OXPHOS complexes based on nuclear non-synonymous polymorphisms. Mitochondrion 12: 237-241. |
Pierron D, Letellier T, Grossman LI (2012) Mitochondrion
Abstract: OXPHOS polymorphisms are known to be population specific and to influence disease. Previous studies have focused on mtDNA polymorphisms. Based on a world sampling of 629 unrelated individuals, we have now studied the polymorphisms of the 80 genes encoding OXPHOS nuclear subunits. We have shown that (i) amino-acid replacement frequencies are significantly correlated with their pathogenicity probability, and (ii) populations can be distinguished based only on amino-acid replacements in nuclear encoded OXPHOS subunits. These results are congruent with the major mtDNA haplogroups, which suggests that OXPHOS complexes are different across the populations in both nuclear and in mitochondrial encoded subunits. • Keywords: mtDNA haplogroups
• O2k-Network Lab: FR Bordeaux Letellier T
Labels:
Organism: Human
mtDNA, nDNA, populations
