LEAK state: Difference between revisions
No edit summary |
No edit summary |
||
Line 10: | Line 10: | ||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Respiratory state | |mitopedia topic=Respiratory state | ||
|type=Respiration | |type=Respiration | ||
}} | }} |
Revision as of 16:04, 9 March 2011
Description
The LEAK state, L, is the non-phosphorylating resting state of intrinsic uncoupled or dyscoupled respiration when oxygen flux is maintained mainly to compensate for the proton leak when ATP synthase is not active.
Abbreviation: L
Reference: MiPNet12.15; List of respiratory states
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
LEAK
- Not State 2 in the classical sense, but frequently called 'State 2', State 4, State 4o, basal state, or inactive state of respiration.
Respiration compensating for the proton leak is the main component of LEAK respiration. If proton leak were the only component involved, it would make sense to simply write leak respiration for the compensatory oxygen flux. Proton slip and cation cycling, however, are also involved to a larger or smaller extent to stimulate LEAK respiration. The upper case 'LEAK', therefore, should make us aware that this is more accurately considered as an acronym, and cannot be taken as a definitive delineation of the stimulatory mechanism in the LEAK state of respiration.