N-junction: Difference between revisions
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|description=[[File:SUIT-catg N.jpg|right|300px|N-junction]] | |description=[[File:SUIT-catg N.jpg|right|300px|N-junction]] | ||
The '''N-junction''' is a junction for [[convergent electron flow]] in the [[electron transfer system]] ( | The '''N-junction''' is a junction for [[convergent electron flow]] in the [[electron transfer system]] (ET-pathway) from type N substrates (''further details'' ยป[[N-pathway control state]]) through the mt-[[NADH]] pool to [[Complex I]] (CI), and further transfer through the [[Q-junction]] to [[Complex III]] (CIII). Representative type N substrates are pyruvate (P), glutamate (G) and malate (M). The corresponding dehydrogenases ([[Pyruvate dehydrogenase |PDH]], [[Glutamate dehydrogenase |GDH]], [[Malate dehydrogenase |MDH]]) and some additional TCA cycle dehydrogenases ([[isocitrate dehydrogenase]], [[oxoglutarate dehydrogenase]] generate NADH, the substrate of [[Complex I]] (CI). The concept of the N-junction and [[F-junction]] provides a basis for defining [[categories of SUIT protocols]] based on [[pathway control state]]s. | ||
|info=[[N-pathway control state]] | |info=[[N-pathway control state]] | ||
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Revision as of 13:47, 20 October 2017
Description
The N-junction is a junction for convergent electron flow in the electron transfer system (ET-pathway) from type N substrates (further details ยปN-pathway control state) through the mt-NADH pool to Complex I (CI), and further transfer through the Q-junction to Complex III (CIII). Representative type N substrates are pyruvate (P), glutamate (G) and malate (M). The corresponding dehydrogenases (PDH, GDH, MDH) and some additional TCA cycle dehydrogenases (isocitrate dehydrogenase, oxoglutarate dehydrogenase generate NADH, the substrate of Complex I (CI). The concept of the N-junction and F-junction provides a basis for defining categories of SUIT protocols based on pathway control states.
Reference: N-pathway control state
MitoPedia concepts:
MiP concept,
SUIT concept
MitoPedia methods:
Respirometry
Contributed by Gnaiger E 2016-02-12; edited 2016-08-28, 2017-01-03.