Al-Gindan 2015 Br J Nutr

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Al-Gindan YY, Hankey CR, Govan L, Gallagher D, Heymsfield SB, Lean ME (2015) Derivation and validation of simple anthropometric equations to predict adipose tissue mass and total fat mass with MRI as the reference method. Br J Nutr 114:1852-67.

PMID: 26435103 Open Access

Al-Gindan YY, Hankey CR, Govan L, Gallagher D, Heymsfield SB, Lean ME (2015) Br J Nutr

Abstract: The reference organ-level body composition measurement method is MRI. Practical estimations of total adipose tissue mass (TATM), total adipose tissue fat mass (TATFM) and total body fat are valuable for epidemiology, but validated prediction equations based on MRI are not currently available. We aimed to derive and validate new anthropometric equations to estimate MRI-measured TATM/TATFM/total body fat and compare them with existing prediction equations using older methods. The derivation sample included 416 participants (222 women), aged between 18 and 88 years with BMI between 15路9 and 40路8 (kg/m2). The validation sample included 204 participants (110 women), aged between 18 and 86 years with BMI between 15路7 and 36路4 (kg/m2). Both samples included mixed ethnic/racial groups. All the participants underwent whole-body MRI to quantify TATM (dependent variable) and anthropometry (independent variables). Prediction equations developed using stepwise multiple regression were further investigated for agreement and bias before validation in separate data sets. Simplest equations with optimal R (2) and Bland-Altman plots demonstrated good agreement without bias in the validation analyses: men: TATM (kg)=0路198 weight (kg)+0路478 waist (cm)-0路147 height (cm)-12路8 (validation: R 2 0路79, CV=20 %, standard error of the estimate (SEE)=3路8 kg) and women: TATM (kg)=0路789 weight (kg)+0路0786 age (years)-0路342 height (cm)+24路5 (validation: R (2) 0路84, CV=13 %, SEE=3路0 kg). Published anthropometric prediction equations, based on MRI and computed tomographic scans, correlated strongly with MRI-measured TATM: (R (2) 0路70-0路82). Estimated TATFM correlated well with published prediction equations for total body fat based on underwater weighing (R (2) 0路70-0路80), with mean bias of 2路5-4路9 kg, correctable with log-transformation in most equations. In conclusion, new equations, using simple anthropometric measurements, estimated MRI-measured TATM with correlations and agreements suitable for use in groups and populations across a wide range of fatness.

Bioblast editor: Gnaiger E

Labels: Pathology: Obesity 

Organism: Human  Tissue;cell: Fat  Preparation: Intact organism 

BMI, Fat 

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