Difference between revisions of "Woessner 2020 Thesis"

Latest revision as of 13:43, 14 July 2021

Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198.

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Woessner Mary N (2020) PhD Thesis

Abstract: Chronic heart failure (CHF) is characterised by an inability of the heart to pump enough blood to meet the body’s metabolic needs, resulting in exercise intolerance. A reduction in nitric oxide (NO) bioavailability has been implicated as an initiator and/or contributor to many of the peripheral skeletal tissue dysfunctions that contribute to the exercise intolerance in patients with CHF. Inorganic nitrate supplementation has been identified as an important mediator of exercise tolerance via increasing NO bioavailability, but the potential efficacy of this on patients with heart failure with reduced ejection fraction (HFrEF) as well as the effect on vascular function is not well understood and was the focus of Study 1. Additionally, to our knowledge, no previous study has examined the potential impact of nitrate supplementation on cardiac performance during submaximal exercise and mitochondrial respiration in individuals with HFrEF. These were the foci of Studies 2 and 3 respectively.

• Bioblast editor: Reiswig R

Labels: MiParea: Respiration, Exercise physiology;nutrition;life style Pathology: Cardiovascular

Organism: Human Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue Enzyme: Complex I

Coupling state: LEAK, OXPHOS, ET Pathway: N, S, NS, ROX HRR: Oxygraph-2k

2021-07

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 {{Publication
-|title=Mary N. Woessner (2020) BEET-HF: the effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. Nutrients 12:2132..
+|title=Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198.
-|info=[https://pubmed.ncbi.nlm.nih.gov/32709051/ PMID: 32709051 Open Access]
+|info=[https://vuir.vu.edu.au/40041/ Open Access]
-|authors=Woessner Mary N, Levinger Itamar, Allen Jason D, McIlvenna Luke C, Neil Christopher
+|authors=Woessner Mary N
 |year=2020
-|journal=Nutrients
+|journal=PhD Thesis
-|abstract=Heart failure with reduced ejection fraction (HFrEF) is a common end point for patientswith coronary artery disease and it is characterized by exercise intolerance due, in part, to a reductionin cardiac output. Nitric oxide (NO) plays a vital role in cardiac function and patients with HFrEFhave been identified as having reduced vascular NO. This pilot study aimed to investigate if nitratesupplementation could improve cardiac measures during acute, submaximal exercise.  Five maleparticipants (61±3 years) with HFrEF (EF 32±2.2%) completed this pilot study.  All participantssupplemented with inorganic nitrate (beetroot juice) or a nitrate-depleted placebo for ~13 days priorto testing. Participants completed a three-stage submaximal exercise protocol on a recumbent cycleergometer with simultaneous echocardiography for calculation of cardiac output (Q), stroke volume(SV), and total peripheral resistance (TPR). Heart rate and blood pressure were measured at restand during each stage. Both plasma nitrate (mean=~1028%,''p''=0.004) and nitrite (mean=~109%,''p''=0.01) increased following supplementation. There were no differences between interventions atrest, but the percent change in SV and Q from rest to stage two and stage three of exercise was higherfollowing nitrate supplementation (allp>0.05, ES>0.8). Both interventions showed decreases inTPR during exercise, but the percent reduction TPR in stages two and three was greater followingnitrate supplementation (p=0.09, ES=0.98 andp=0.14, ES=0.82, respectively).   There wereclinically relevant increases in cardiac function during exercise following supplementation withnitrate. The findings from this pilot study warrant further investigation in larger clinical trials.
+|abstract=Chronic heart failure (CHF) is characterised by an inability of the heart to pump enough
+blood to meet the body’s metabolic needs, resulting in exercise intolerance. A reduction
+in nitric oxide (NO) bioavailability has been implicated as an initiator and/or contributor
+to many of the peripheral skeletal tissue dysfunctions that contribute to the exercise
+intolerance in patients with CHF. Inorganic nitrate supplementation has been identified
+as an important mediator of exercise tolerance via increasing NO bioavailability, but the
+potential efficacy of this on patients with heart failure with reduced ejection fraction
+(HFrEF) as well as the effect on vascular function is not well understood and was the
+focus of Study 1. Additionally, to our knowledge, no previous study has examined the
+potential impact of nitrate supplementation on cardiac performance during submaximal
+exercise and mitochondrial respiration in individuals with HFrEF. These were the foci
+of Studies 2 and 3 respectively.
+|editor=[[Reiswig R]]
+}}
+{{Labeling
+|area=Respiration, Exercise physiology;nutrition;life style
+|diseases=Cardiovascular
+|organism=Human
+|tissues=Skeletal muscle
+|preparations=Permeabilized tissue
+|enzymes=Complex I
+|couplingstates=LEAK, OXPHOS, ET
+|pathways=N, S, NS, ROX
+|instruments=Oxygraph-2k
+|additional=2021-07
 }}
-{{Labeling}}