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Difference between revisions of "Umbrasas 2019 MitoFit Preprint Arch EA"

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|title=Umbrasas Danielius, Vanagas T, Cizas P, Borutaite V (2019) Itaconic acid decreases mitochondrial respiration and ROS generation in brain tissue. MitoFit Preprint Arch [[doi:10.26124/mitofit:EA19.MiPSchool.0001]].
|title=Umbrasas Danielius, Vanagas T, Cizas P, Borutaite V (2019) Itaconic acid decreases mitochondrial respiration and ROS generation in brain tissue. MitoFit Preprint Arch [[doi:10.26124/mitofit:ea19.MiPSchool.0001]].
|info=[[File:MitoFit Preprint Arch pdf.png|left|160px|link=http://www.mitofit.org/images/e/e9/Umbrasas_2019_MitoFit_Preprint_Arch_doi_10.26124mitofitEA19.MiPSchool.0001.pdf|MitoFit pdf]] <big><big>'''[http://www.mitofit.org/images/e/e9/Umbrasas_2019_MitoFit_Preprint_Arch_doi_10.26124mitofitEA19.MiPSchool.0001.pdf Itaconic acid decreases mitochondrial respiration and ROS generation in brain tissue]'''</big></big>
|info=[[File:MitoFit Preprint Arch pdf.png|left|160px|link=http://www.mitofit.org/images/e/e9/Umbrasas_2019_MitoFit_Preprint_Arch_doi_10.26124mitofitEA19.MiPSchool.0001.pdf |MitoFit pdf]] [http://www.mitofit.org/images/e/e9/Umbrasas_2019_MitoFit_Preprint_Arch_doi_10.26124mitofitEA19.MiPSchool.0001.pdf Itaconic acid decreases mitochondrial respiration and ROS generation in brain tissue]
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|authors=Umbrasas D, Vanagas T, Cizas P, Borutaite V
|authors=Umbrasas D, Vanagas T, Cizas P, Borutaite V
|year=2019
|year=2019-06-03
|journal=MitoFit Preprint Arch
|journal=MitoFit Preprint Arch
|abstract=Itaconic acid (IA) is a recently discovered mammalian metabolite which is produced by macrophages upon pro-inflammatory activation: in quiescent bone marrow – derived macrophages (BMDMs). IA is hardly detectable but upon lipopolysaccharide (LPS) stimulation it reaches millimolar concentrations [1]. Recently reported physiological roles of IA include inhibition of bacterial enzyme isocitrate lyase (bactericidal activity) and the inhibition of a Krebs cycle enzyme succinate dehydrogenase (SDH) in the host cells (which has been shown for BMDMs) [2,3]. By inhibiting SDH, IA regulates succinate (a pro-inflammatory metabolite) levels thus remodelling the host cells metabolism during inflammation [3]. Microglia are macrophages residing in the brain, however, it is not clear whether these cells can also produce IA. In general, there has been very little research on IA effects on brain tissue. Therefore, in this study, we investigated whether IA exerts an effect on brain mitochondrial respiration and ROS generation and whether IA is neurotoxic. Β 
|abstract=Version 1 ('''v1''') '''2019-06-03''' [http://www.mitofit.org/images/e/e9/Umbrasas_2019_MitoFit_Preprint_Arch_doi_10.26124mitofitEA19.MiPSchool.0001.pdf doi:10.26124/mitofit:ea19.MiPSchool.0001]
|keywords=
Β 
Itaconic acid (IA) is a recently discovered mammalian metabolite which is produced by macrophages upon pro-inflammatory activation: in quiescent bone marrow – derived macrophages (BMDMs). IA is hardly detectable but upon lipopolysaccharide (LPS) stimulation it reaches millimolar concentrations [1]. Recently reported physiological roles of IA include inhibition of bacterial enzyme isocitrate lyase (bactericidal activity) and the inhibition of a Krebs cycle enzyme succinate dehydrogenase (SDH) in the host cells (which has been shown for BMDMs) [2,3]. By inhibiting SDH, IA regulates succinate (a pro-inflammatory metabolite) levels thus remodelling the host cells metabolism during inflammation [3]. Microglia are macrophages residing in the brain, however, it is not clear whether these cells can also produce IA. In general, there has been very little research on IA effects on brain tissue. Therefore, in this study, we investigated whether IA exerts an effect on brain mitochondrial respiration and ROS generation and whether IA is neurotoxic. Β 
|keywords=[[TCA cycle]]
|editor=[[Iglesias-Gonzalez J]]
|editor=[[Iglesias-Gonzalez J]]
|mipnetlab=[[LT Kaunas Borutaite V]]
}}
}}
Β 
== Affiliations ==
Umbrasas Danielius(1), Vanagas T(2), Cizas P(1), Borutaite V(1)
::::# Neuroscience Institute, Lithuanian Univ of Health Sciences - [email protected]
::::# Faculty of Medicine, Lithuanian Univ of Health Sciences


== References ==
== References ==
Line 20: Line 25:
:::# Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, et al. (2016) Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metab; 24:158–66.
:::# Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, et al. (2016) Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metab; 24:158–66.
:::# Gnaiger E., Kuznetsov A.V., Schneeberger S., Seiler R., Brandacher G., Steurer W., Margreiter R. (2000) Mitochondria in the Cold. In: Heldmaier G., Klingenspor M., editors. Life in the Cold. Springer; Heiderlberg, Germany: pp. 431–442.
:::# Gnaiger E., Kuznetsov A.V., Schneeberger S., Seiler R., Brandacher G., Steurer W., Margreiter R. (2000) Mitochondria in the Cold. In: Heldmaier G., Klingenspor M., editors. Life in the Cold. Springer; Heiderlberg, Germany: pp. 431–442.
== Event ==
::::Β» [[MiPschool Coimbra 2019]]


== Preprints for [[Gentle Science]] ==
== Preprints for [[Gentle Science]] ==
{{MitoFit preprint}}
{{MitoFit preprint}}


{{Labeling
{{Labeling
|additional=Preprints
|additional=Preprints
}}
}}

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Umbrasas 2019 MitoFit Preprint Arch EA

Publications in the MiPMap
Umbrasas Danielius, Vanagas T, Cizas P, Borutaite V (2019) Itaconic acid decreases mitochondrial respiration and ROS generation in brain tissue. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0001.

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Itaconic acid decreases mitochondrial respiration and ROS generation in brain tissue


Umbrasas D, Vanagas T, Cizas P, Borutaite V (2019-06-03) MitoFit Preprint Arch

Abstract: Version 1 (v1) 2019-06-03 doi:10.26124/mitofit:ea19.MiPSchool.0001

Itaconic acid (IA) is a recently discovered mammalian metabolite which is produced by macrophages upon pro-inflammatory activation: in quiescent bone marrow – derived macrophages (BMDMs). IA is hardly detectable but upon lipopolysaccharide (LPS) stimulation it reaches millimolar concentrations [1]. Recently reported physiological roles of IA include inhibition of bacterial enzyme isocitrate lyase (bactericidal activity) and the inhibition of a Krebs cycle enzyme succinate dehydrogenase (SDH) in the host cells (which has been shown for BMDMs) [2,3]. By inhibiting SDH, IA regulates succinate (a pro-inflammatory metabolite) levels thus remodelling the host cells metabolism during inflammation [3]. Microglia are macrophages residing in the brain, however, it is not clear whether these cells can also produce IA. In general, there has been very little research on IA effects on brain tissue. Therefore, in this study, we investigated whether IA exerts an effect on brain mitochondrial respiration and ROS generation and whether IA is neurotoxic. β€’ Keywords: TCA cycle β€’ Bioblast editor: Iglesias-Gonzalez J β€’ O2k-Network Lab: LT Kaunas Borutaite V

Affiliations

Umbrasas Danielius(1), Vanagas T(2), Cizas P(1), Borutaite V(1)

  1. Neuroscience Institute, Lithuanian Univ of Health Sciences - [email protected]
  2. Faculty of Medicine, Lithuanian Univ of Health Sciences

References

  1. Meiser J, Kraemer L, Jaeger C, Madry H, Link A, Lepper PM, Hiller K, Schneider JG (2018) Itaconic acid indicates cellular but not systemic immune system activation. Oncotarget;9(63):32098-32107.
  2. Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, Binz T, Wegner A, Tallam A, Rausell A, Buttini M, Linster CL, Medina E, et al. (2013) Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc Natl Acad Sci U S A.; 110:7820–5.
  3. Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, et al. (2016) Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metab; 24:158–66.
  4. Gnaiger E., Kuznetsov A.V., Schneeberger S., Seiler R., Brandacher G., Steurer W., Margreiter R. (2000) Mitochondria in the Cold. In: Heldmaier G., Klingenspor M., editors. Life in the Cold. Springer; Heiderlberg, Germany: pp. 431–442.

Event

Β» MiPschool Coimbra 2019


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