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Property "Has-20abstract" (as page type) with input value "Version-201-20(-27-27'v1-27-27')-20-27-27'2019-2D06-2D11-27-27'-20-5Bhttp:-2F-2Fwww.mitofit.org-2Fimages-2Fd-2Fdc-2FSchoepf_2019_MitoFit_Preprint_Arch.pdf-20doi:10.26124-2Fmitofit:190003-5D-0A-0ARewiring-20of-20energy-20metabolism-20and-20adaptation-20of-20mitochondrial-20respiratory-20functions-20are-20considered-20to-20impact-20on-20prostate-20cancer-20development-20and-20progression.-20High-2Dresolution-20respirometry-20of-20paired-20benign-20and-20malignant-20human-20prostate-20tissue-20samples-20revealed-20reduced-20respiratory-20capacities-20with-20NADH-2Dpathway-20substrates-20glutamate-20and-20malate-20in-20malignant-20tissue-20and-20a-20significant-20metabolic-20shift-20towards-20respiratory-20capacity-20with-20succinate,-20particularly-20in-20high-2Dgrade-20tumors.-20The-20load-20of-20potentially-20deleterious-20mitochondrial-2DDNA-20mutations-20was-20higher-20in-20tumor-20tissue-20and-20associated-20with-20unfavorable-20risk-20factors.-20High-20levels-20of-20potentially-20deleterious-20mutations-20in-20mitochondrial-20Complex-20I-2Dencoding-20genes-20were-20associated-20with-20a-2070-25-20reduction-20in-20NADH-2Dpathway-20capacity-20and-20compensation-20by-20increased-20S-2Dpathway-20capacity.-20Structural-20analyses-20of-20these-20mutations-20revealed-20amino-20acid-20alterations-20leading-20to-20potentially-20deleterious-20effects-20on-20Complex-20I,-20supporting-20a-20causal-20relationship.-20RNA-2Dseq-20revealed-20a-20signature-20of-20metabolic-20enzymes-20corresponding-20to-20the-20altered-20mitochondrial-20respiratory-20pathways-20and-20enabled-20extraction-20of-20a-20metagene-20set-20for-20prediction-20of-20shorter-20disease-2Dfree-20survival." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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