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Property "Has-20abstract" (as page type) with input value "Version-201-20(-27-27'v1-27-27')-20-27-27'2019-2D06-2D03-27-27'-20-5Bhttp:-2F-2Fwiki.oroboros.at-2Fimages-2F0-2F0a-2FGoncalves_2019_MitoFit_Preprint_Arch_doi_10.26124mitofitEA19.MiPSchool.0002.pdf-20doi:10.26124-2Fmitofit:ea19.MiPSchool.0002-5D-0A-0AParkinson-20disease-20(PD)-20is-20considered-20the-20second-20most-20common-20neurodegenerative-20disorder-20in-20the-20world-20and-20is-20related-20mainly-20with-20aging.-20PD-20is-20characterized-20by-20loss-20of-20dopaminergic-20neurons-20and-20formation-20of-20protein-20aggregates,-20such-20as-20α-2Dsynuclein-20-5B1-5D,-20leading-20to-20motor-20dysfunction,-20and-20impairment-20of-20cognitive-20and-20memory-20functions-20-5B2-5D.-20The-20pathology-20and-20symptoms-20of-20PD-20are-20well-20described,-20although-20its-20mechanisms-20and-20causes-20remain-20unclear.-20One-20mechanism-20involved-20in-20PD-20is-20mitochondrial-20dysfunction-20-5B3-5D.-20Mutation-20in-20genes-20involved-20in-20mitochondrial-20quality-20control,-20such-20as-20PARK2-20and-20Pink1,-20produce-20PD-20symptoms-20-5B4-5D.-20These-20genes-20code-20for-20proteins-20such-20as-20PINK1-20(PTEN-20induced-20kinase-201)-20that-20is-20a-20serine-2Fthreonine-20kinase-20involved-20in-20mitochondrial-20network-20quality-20control-20-5B5-5D.-20In-20this-20work-20we-20evaluated-20mitochondrial-20quality-20control-20using-20Pink1-20knockout-20of-20Drosophila-20melanogaster-20in-20different-20lifetime." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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