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From Bioblast
- * [[dicarboxylate carrier]] * [[tricarboxylate carrier]]253 bytes (23 words) - 12:41, 2 December 2021
- ...carrier and the 2-oxoglutarate carrier exchanging malate<sup>2-</sup> for 2-oxoglutarate<sup>2-</sup>. Cytosolic and mitochondrial malate dehydrogenase and transami ::::* Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Bi735 bytes (91 words) - 19:30, 1 January 2021
- ...se]] (OgDH). The 2-oxoglutarate carrier exchanges malate<sup>2-</sup> for 2-oxoglutarate<sup>2-</sup> as part of the [[malate-aspartate shuttle]]. In the cytosol, o1 KB (142 words) - 09:38, 11 September 2020
- |description=The '''dicarboxylate carrier''' is a transporter which catalyses the electroneutral exchange of [[malate334 bytes (43 words) - 19:39, 1 January 2021
- ...rate]]), representing the [[glutamate-anaplerotic pathway control state]]. 2-oxoglutarate (α-ketoglutarate) is formed from isocitrate (isocitrate dehydrogenase, fro3 KB (316 words) - 13:14, 2 August 2023
- ...genase. If the 2-oxoglutarate carrier does not outcompete these sources of 2-oxoglutarate, then the TCA cycle operates in full circle with external pyruvate&malate&g2 KB (284 words) - 18:29, 17 March 2022
- |description=The [[dicarboxylate carrier]] catalyses the electroneutral exchange of succinate<sup>2-</sup> for HPO<s364 bytes (44 words) - 12:38, 2 December 2021
- ...l matrix by [[glutamate dehydrogenase]] to α-ketoglutarate ([[oxoglutarate|2-oxoglutarate]]), representing the [[glutamate-anaplerotic pathway control state]]. Ammon3 KB (352 words) - 09:26, 4 July 2023
- ...lectron transport chain (ETC), heme oxygenase-2 (HO-2), and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor) prolyl hydroxy1 KB (164 words) - 18:32, 22 March 2021
- ...l function. This regulation involves the mitochondrial glutamate/aspartate carrier aralar which controls mitochondrial substrate supply according to the level |keywords=Glutamate/aspartate carrier aralar, Extramitochondrial Ca (2+), Brain mitochondria2 KB (270 words) - 09:28, 7 May 2020
- ...([[dicarboxylate carrier]], [[tricarboxylate carrier]] and 2-oxoglutarate carrier). Malate alone cannot support respiration of [[Mitochondrial preparations|m4 KB (585 words) - 19:57, 5 February 2022
- ...([[PMS]]) if the 2-oxoglutarate carrier does not outcompete the sources of 2-oxoglutarate3 KB (397 words) - 11:37, 29 February 2024
- ...([[PMS]]) if the 2-oxoglutarate carrier does not outcompete the sources of 2-oxoglutarate.3 KB (424 words) - 14:30, 10 March 2023
- ...The P»-system consists of [[adenine nucleotide translocase]], [[phosphate carrier]], and [[ATP synthase]]. Mitochondrial [[adenylate kinase]], mt-[[creatine ...ase is not involved. However, if succinate is formed in the mt-matrix from 2-oxoglutarate (alpha-ketoglutarate), substrate-level phosphorylation at succinyl-CoA liga2 KB (251 words) - 11:27, 2 June 2020
- |description=The '''tricarboxylate carrier''' in the inner mt-membrane exchanges malate<sup>2-</sup> for citrate<sup>3474 bytes (60 words) - 13:45, 28 March 2017
- ...Colca JR, Kletzien RF, Burgess SC, Finck BN (2014) Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secre ...in anabolic and catabolic intermediary metabolism. Mitochondrial pyruvate carrier 2 (Mpc2) is believed to be a component of the complex that facilitates mito2 KB (258 words) - 14:20, 18 March 2018
- ''See also'': [[Phosphate carrier]] (Pic).943 bytes (136 words) - 12:18, 25 November 2020
- ...ate. [[Succinate]] is lost from the mitochondria through the dicarboxylate carrier. OXPHOS capacity with malate alone is only 1.3% of that with [[PM |Pyruvate2 KB (283 words) - 01:28, 31 December 2020
- ...of this chain. The authors show that vitamin K<sub>2</sub> is an electron carrier, suggesting this small organic molecule as a possible treatment for mitocho1 KB (164 words) - 06:12, 23 October 2023
- ::: '''[[MitoPedia: SUIT]]''' - Carrier control protocol to [[SUIT-003 AmR ce D058]] ...has been designed to study the effect of the [[Carrier control titrations|carrier titrations]] on the respiration in parallel to [[SUIT-003 AmR ce D058]]. Th2 KB (309 words) - 13:44, 7 July 2020
- ...et al<ref>Schefer U, Ammann D, Pretsch E, Oesch U, Simon W (1986) Neutral carrier based Ca<sup>2+</sup>-selective electrode with detection limit in the sub-n1 KB (172 words) - 11:50, 11 November 2020
- ...nucleotide exchange and increased the degree of control, which the ADP/ATP carrier has on State 3 respiration. Important for functional consequences is the fi |keywords=ADP/ATP carrier, Branched-chain fatty acid, Mitochondria, Neurodegeneration, Permeability t3 KB (381 words) - 11:04, 27 March 2018
- ...glutamate to mitochondria via aralar, a mitochondrial glutamate/aspartate carrier. Since this activation is not affected by ruthenium red, glutamate transpor ...genase, α-Ketoglutarate dehydrogenase, Isocitrate dehydrogenase, ATP-Mg/Pi carrier, FAD-glycerol-3-phosphate dehydrogenase, Ca<sup>2+</sup> uniporter, F0F1ATP3 KB (427 words) - 09:29, 7 May 2020
- # Isolated mitochondria of all the yeasts show the possession of a carrier system for dicarboxylic and tricarboxylic anions, phosphate and pyruvate. # The tricarboxylate carrier is also specific for l-malate in all 10 yeasts.3 KB (340 words) - 09:20, 9 November 2016
- ...R, Kletzien RF, Burgess SC, Finck BN (2015) Loss of mitochondrial pyruvate carrier 2 in the liver leads to defects in gluconeogenesis and compensation via pyr ...uconeogenesis, mice with liver-specific deletion of mitochondrial pyruvate carrier 2 (LS-Mpc2<sup>-/-</sup>) were generated. Loss of MPC2 impaired, but did no2 KB (284 words) - 22:00, 17 February 2021
- ...of matrix NADH<sub>F</sub>, was indicated, using citrate (2-oxoglutarate) carrier inhibitors and cytosolic malic enzyme silencing: All changes vanished on th3 KB (477 words) - 15:16, 18 January 2023
- .... At the same time, ItA had no effect on the activity of the dicarboxylate carrier, which catalyzes the transport of succinate across the inner mitochondrial |keywords=Dicarboxylate carrier, Itaconic acid, MPT pore, Mitochondria, Mitochondrial respiration, Oxidativ3 KB (368 words) - 18:19, 6 November 2020
- ...rial glutamate/H+-symporter (SLC25A22) and the mitochondrial dicarboxylate carrier (SLC25A10) in response to treatment with the glucocorticoid dexamethasone (2 KB (275 words) - 18:34, 31 January 2020
- ...-cycle''' refers to the sequential oxidation and reduction of the electron carrier Coenzyme Q (CoQ or [[ubiquinone]]) in mitochondria or plastoquinones in the1 KB (233 words) - 08:07, 30 March 2021
- ...ended: [[SUIT 003 AmR ce D058]] with AmR and [[SUIT 003 AmR ce D059]] with carrier titration as a control. These two protocols have to be done in parallel.2 KB (277 words) - 11:31, 7 March 2024
- ...S, Gygi SP, Brivet M, Thummel CS, Rutter J (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 337: ...12) Identification and functional expression of the mitochondrial pyruvate carrier. Science 337: 93-6.3 KB (377 words) - 16:42, 11 February 2015
- ...> binding sites on the mitochondrial surface, e.g. the glutamate/aspartate carrier (aralar), mediate this regulation. Interactions between htt51Q and distinct3 KB (427 words) - 14:58, 8 June 2015
- |abstract=Mitochondrial carrier homolog 2 (MTCH2) is currently one of the most enigmatic mitochondrial prot1 KB (180 words) - 17:58, 20 February 2024
- ...Lasorsa FM (2017) Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Ne |abstract=The mitochondrial aspartate-glutamate carrier isoform 1 (AGC1) catalyzes a Ca<sup>2+</sup>-stimulated export of aspartate3 KB (418 words) - 16:44, 3 May 2024
- ...ended: [[SUIT 003 AmR ce D058]] with AmR and [[SUIT 003 AmR ce D059]] with carrier titration as a control. These two protocols have to be done in parallel.2 KB (278 words) - 09:38, 9 November 2021
- Mitochondrial carrier homolog 2 (MTCH2) is currently one of the most enigmatic mitochondrial prot2 KB (191 words) - 11:17, 8 February 2024
- ...P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A (2015) Defects in mitophagy promote redox-driven metabolic syndrome in th ...P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A2 KB (337 words) - 23:53, 18 March 2018
- ...ffects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol 102:985-99. ...-sparing TZDs, such as MSDC-0602, interact with the mitochondrial pyruvate carrier (MPC) and inhibit its activity. The MPC complex is composed of two proteins3 KB (464 words) - 10:04, 11 June 2018
- ...N (2020) Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab 2:1232-47. https://doi.org/10.1038/s42255-020-002 ...onditions including diabetes and heart failure. The mitochondrial pyruvate carrier (MPC) complex, composed of MPC1 and MPC2, is required for pyruvate import i2 KB (350 words) - 09:29, 4 September 2023
- ...ended: [[SUIT 003 AmR ce D058]] with AmR and [[SUIT 003 AmR ce D059]] with carrier titration as a control. These two protocols have to be done in parallel.4 KB (615 words) - 23:51, 12 April 2021
- |title=Tsien RY, Rink TJ (1980 ) Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium |info=[https://pubmed.ncbi.nlm.nih.gov/7407109/?from_term=Neutral+carrier+ion-selective+microelectrodes+for+measurement+of+intracellular+free+calcium2 KB (274 words) - 09:16, 7 May 2020
- ...thase was not changed, whereas ATP/ADP-carrier and Voltage dependent anion carrier (VDAC) were upregulated, which may explain the high sensitivity to uncoupli3 KB (457 words) - 09:43, 20 August 2018
- ...on medium: in the absence of phosphate or in the presence of the phosphate carrier inhibitor mersalyl in the phosphate-containing medium, no swelling of the m2 KB (282 words) - 09:04, 5 October 2018
- ...dy B, Cho K, Patti GJ, McCommis KS, Finck BN (2021) Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice. J Biol |abstract=The mitochondrial pyruvate carrier (MPC) is an inner mitochondrial membrane complex that plays a critical role3 KB (376 words) - 17:19, 22 February 2022
- ...r studies are focused on a novel mitochondrial protein named mitochondrial carrier homolog 2 (MTCH2) that mediates the response of mitochondria to stress sign2 KB (285 words) - 16:43, 12 July 2023
- ...results show directly that under physiological conditions the major energy carrier from mitochondria into cytoplasm is PCr, produced by mitochondrial creatine2 KB (266 words) - 11:08, 26 May 2015
- |keywords=ADP–ATP exchange, Adenine nucleotide carrier, Adenine nucleotide translocase, Bioenergetics, Oxidative phosphorylation,3 KB (420 words) - 11:49, 27 October 2023
- ...etabolite transport is mediated by proteins belonging to the mitochondrial carrier family. In this study, we have investigated the abundance and transport act2 KB (233 words) - 14:19, 9 November 2016
- ...l, and the abundance and function of selected inner mitochondrial membrane carrier proteins in muscle collected from hypermetabolic burn patients and healthy3 KB (434 words) - 08:11, 13 September 2018
- ...ended: [[SUIT-003 AmR ce D058]] with AmR and [[SUIT-003 AmR ce D059]] with carrier titration as a control. These two protocols should be done in parallel.5 KB (832 words) - 00:10, 13 April 2021
- ...ccinate is transported across the inner mt-membrane by the [[dicarboxylate carrier]]. The plasma membrane of many cell types is impermeable for succinate (but3 KB (467 words) - 15:06, 17 December 2022
- ...ended: [[SUIT 003 AmR ce D058]] with AmR and [[SUIT 003 AmR ce D059]] with carrier titration as a control. These two protocols have to be done in parallel.6 KB (864 words) - 23:56, 12 April 2021
- |abstract=Coenzyme Q (CoQ) is a unique electron carrier in the mitochondrial respiratory chain, which is synthesized on-site by a n2 KB (234 words) - 16:11, 3 November 2021
- ...te is imported into the mitochondrial matrix by the mitochondrial pyruvate carrier (MPC) for oxidation by the TCA cycle to support oxidative phosphorylation.2 KB (240 words) - 13:34, 14 June 2017
- ...piration at concentrations >10 µM. (2) After titration of acylcarnitine or carrier, NADH-linked substrates (N: pyruvate, malate, glutamate), succinate (S), an3 KB (468 words) - 17:22, 22 March 2023
- |keywords=Colorectal cancer, Lipid synthesis, Mitochondria, Mitochondrial carrier, Oxidative stress, Tumor metabolic reprogramming, Tumor metabolism, Uncoupl2 KB (306 words) - 14:59, 11 November 2019
- ...nimal and plant cells4,5,6,7,8,9 and form a subfamily of the mitochondrial carrier family10. Physiological uncoupling of oxidative phosphorylation must be str2 KB (240 words) - 22:15, 16 February 2021
- ...diabetes. The SLC16A13 gene encodes SLC16A13/MCT13, a member of the solute carrier 16 family of monocarboxylate transporters. Despite its potential importance2 KB (341 words) - 11:25, 8 July 2021
- ...tion complexes, C (CI, CIII, CIV, ATP synthase, ATP/ADP carrier, phosphate carrier), predict that all OXPHOS complexes are directly activated in parallel with4 KB (526 words) - 11:17, 28 April 2017
- .../sub>' H<sup>+</sup>/monocarboxylate cotransporter known as the [[pyruvate carrier]]. Similarly, the plasma membrane of many cell types has H<sup>+</sup>/mono4 KB (628 words) - 11:20, 17 June 2021
- ...ion='''Adenosine triphosphate''' is a nucleotid and functions as the major carrier of chemical energy in the cells. As it transfers its energy to other molecu5 KB (732 words) - 15:07, 17 October 2022
- ...ntrolled also by CIV) (Fig. 1). In CRC tissue the value of FCC for ATP/ADT carrier is significantly lowered as compared with healthy intestinal tissue (Fig. 1 ...I and III, whereas in normal bowel tissue these are complex II and ATP/ADP carrier; 2) in human colorectal carcinomas some components of the mitochondrial ele7 KB (1,016 words) - 14:53, 23 January 2019
- ...nal and its occurrence should alert us to the possibility of an underlying carrier or channel. (4) Leak pathways are very likely localized to protein-lipid in2 KB (292 words) - 18:32, 16 January 2021
- ...d lower lactate dehydrogenase A content and greater mitochondrial pyruvate carrier content. Markers of mitochondrial biogenesis, including AMPK activation lev2 KB (318 words) - 08:42, 2 July 2015
- ...ormal synthesis. We postulate that, in addition to its role as an electron carrier between Complexes III and IV, CYTc influences Complex IV levels in plants,2 KB (325 words) - 16:19, 5 July 2023
- ...deficient Complex I substrate supply induced by the mitochondrial pyruvate carrier inhibitor UK5099 and cytochrome c release induced by the anti-apoptotic BCL2 KB (326 words) - 03:19, 24 August 2021
- ...e both L-LAC and D-LAC [3,4]. Both the isomers can enter mitochondria in a carrier-mediated manner, probably in symport with protons. Moreover, externally add4 KB (573 words) - 11:23, 13 April 2015
- ...Omy, starting at very low concentrations (in the nM range). In parallel, [[carrier control titrations]], i.e. ethanol titrations, should be performed in the o6 KB (917 words) - 12:57, 29 April 2024
- ...ct of autophagy in the cell, we demonstrated that this lipophilic electron carrier is a native constituent of a lysosomal electron transport chain, which prom3 KB (388 words) - 22:18, 16 February 2021
- | inorganic phosphate carrier || [[Phosphate carrier]] || PiC || - || Fig. 1C15 KB (2,142 words) - 23:29, 6 February 2021
- ...chain drives the production of ATP, which is then used as a primary energy carrier in virtually all cellular processes. Minimal perturbations of the respirato4 KB (662 words) - 19:47, 6 November 2023
- ...Complex II was not impaired by TEGDMA. The beneficial effects of electron carrier compound methylene blue (MB) are proven in many disease models where mitoch3 KB (360 words) - 12:00, 21 September 2020
- ...g R, Orynbayeva Z (2015) Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria. Am J5 KB (637 words) - 19:10, 10 January 2022
- ...mitochondrial uncoupling proteins (UCPs). UCPs belong to the mitochondrial carrier family and play the role of main catalysts of futile proton leak of the pro3 KB (355 words) - 13:50, 28 August 2017
- ...ct=Uncoupling protein 3 (UCP3) is a member of mitochondrial inner membrane carrier family. Earlier we have demonstrated that UCP3 is upregulated in skeletal m3 KB (400 words) - 10:58, 4 September 2015
- ...ility and its further impact on development of NAFLD. According to my next carrier steps, I hope I will finish my medicine studies in two years and become a d3 KB (437 words) - 11:26, 6 September 2022
- ...mitochondria (BM) via aralar [2-7], the mitochondrial glutamate/aspartate carrier. Whereas OXPHOS capacity with pyruvate+malate is only slightly influenced b7 KB (1,002 words) - 11:12, 28 April 2017
- ...the presence of the myosin II ATPase inhibitor blebbistatin (25 µM) versus carrier; (3) ‘normoxia’ (200-100 µM) versus hyperoxia (450-250 µM. NADH (N-), ...00 px]] Figure 1. [[SUIT-008 O2 pfi D014]] protocol. 25 µM blebbistatin or carrier was added to Buffer Z and MiR05-Kit. NADH-pathway (N-pathway) in LEAK (1PM)7 KB (952 words) - 19:05, 10 January 2022
- ...ns, we conclude that the adenine nucleotide translocase, the dicarboxylate carrier, and the alpha-ketoglutarate exchanger are partially inhibited by chloride.10 KB (1,407 words) - 19:20, 9 February 2022
- ...Δ''ψ''<sub>mt</sub> by electrogenic exchange of ATP4-/ADP3- by the ATP/ADP carrier (AAC) and hydrolytic activity of the soluble F1-ATPase [2]. So far, it has4 KB (564 words) - 14:23, 26 March 2018
- |description='''Uncoupling proteins''' (UCPs) are mitochondrial anion carrier proteins that can be found in the inner mitochondrial membranes of animals4 KB (559 words) - 14:23, 8 June 2020
- ...(mtIM) proteins, the very-long chain acyl-CoA dehydrogenase, the phosphate carrier, and the adenine nucleotide translocase 2 were present in association with5 KB (659 words) - 16:48, 12 December 2017
- ...ol factors, which paralleled greater expression of mitochondrial phosphate carrier protein and some respiratory complex subunits.4 KB (578 words) - 18:37, 10 January 2022
- ...(rs749249430) in NDUFAF3, a CI assembly factor (Q module). Pt A is also a carrier for TIMM13 and CLPX (Table 1, Figure 1).4 KB (564 words) - 15:19, 27 June 2019
- ...s of malate dehydrogenase (…), citrate synthase (…), or the tricarboxylate carrier (…) would reduce measured oxygen flux, giving a false reading of the rate3 KB (437 words) - 08:39, 3 April 2023
- ...ment:'' This definition is too narrow: The ANT and the inorganic phosphate carrier are additional essential components of the OXPHOS system [1].6 KB (784 words) - 08:54, 6 February 2024
- ...charomyces cerevisiae'' mitochondria which differ in energy production and carrier involvement. https://doi.org/doi:10.1016/j.bbabio.2003.10.0084 KB (587 words) - 08:49, 28 July 2022
- ...er JH, Van Raamsdonk JM, Colca JR, Brundin P (2016) Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental mo6 KB (982 words) - 14:09, 26 March 2018
- ...nvert ADP into ATP, mediated by the enzyme ATP synthase. ATP is the energy carrier used as fuel in cellular processes. Mitochondrial uncoupling makes the conv7 KB (1,111 words) - 12:28, 2 April 2012
- ...eletal muscle, the phosphorylation system (ANT, ATP synthase and phosphate carrier) exerts significant control over respiration in the brain.6 KB (803 words) - 18:16, 10 January 2022
- ...ibility that 6mA may also be transmitted across generations and serve as a carrier of inheritable information. Using ''Caenorhabditis elegans'' as a model, he4 KB (588 words) - 02:54, 1 March 2020
- ...enerally considered to be associated with the inhibition of the enoyl-acyl carrier protein reductase (ENR), a key enzyme in the biosynthesis of fatty acids. A9 KB (1,275 words) - 10:32, 16 October 2018
- |contact (if required by carrier): Michael Walter-Vracevic7 KB (1,045 words) - 13:07, 9 November 2023
- ...via UPS or GLS (depending on country). If the customer chooses a different carrier, the costs might change.11 KB (1,599 words) - 14:45, 2 October 2023
- ...osphorylation system consists of adenine nucleotide translocase, phosphate carrier, and ATP synthase, which carry out the steps in the phosphorylation pathway29 KB (4,269 words) - 09:03, 13 May 2024
- |Heather Wilkins - Dicarboxylate carrier-mediated transport of glutathione into mitochondria determines neuronal sus14 KB (1,865 words) - 16:38, 30 June 2017
- ...yard JCW, Halestrap AP (2003) Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevidiae. Biochem J 374:607-11.25 KB (3,492 words) - 06:44, 13 January 2021
- ::::# Careful: Ethanol as a carrier for oligomycin and FCCP exerts a chemical side effect on the TPP<sup>+</sup37 KB (5,710 words) - 15:30, 16 May 2023
- ...m biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1. Mol Psychiatry 15, 38-52, doi:10.1038/mp.2008.63 (2010).13 KB (1,727 words) - 08:19, 8 January 2023
- ...yard JCW, Halestrap AP (2003) Identification of the mitochondrial pyruvate carrier in ''Saccharomyces cerevidiae''. Biochem J 374:607-11.34 KB (4,820 words) - 04:08, 23 November 2021
- ...yard JCW, Halestrap AP (2003) Identification of the mitochondrial pyruvate carrier in ''Saccharomyces cerevidiae''. Biochem J 374:607-11.89 KB (12,074 words) - 17:54, 6 May 2024
- ...g R, Orynbayeva Z (2015) Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria. Am J85 KB (11,819 words) - 14:18, 10 January 2022
- ...yard JCW, Halestrap AP (2003) Identification of the mitochondrial pyruvate carrier in ''Saccharomyces cerevidiae''. Biochem J 374:607-11.51 KB (7,005 words) - 04:36, 19 July 2022
- ...s, Permeabilized muscle fibers, Permeabilized tissue, Phosphate, Phosphate carrier, Protonmotive force, Publication efficiency, Residual oxygen consumption, R59 KB (8,156 words) - 13:41, 1 May 2024