L/E coupling-control ratio

high-resolution terminology - matching measurements at high-resolution

L/E coupling-control ratio

Description

The ETS control ratio, or L/E coupling control ratio [1,2], is the flux ratio of LEAK respiration over ETS capacity, as determined by measurement of oxygen consumption in sequentially induced states L and E of respiration. The ETS control ratio is an index of uncoupling or dyscoupling at constant ETS capacity. L/E increases with uncoupling from a theoretical minimum of 0.0 for a fully coupled system, to 1.0 for a fully uncoupled system [3].

Abbreviation: L/E

Reference: Gnaiger 2012 MitoPathways

MitoPedia methods: Respirometry 

MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. 

Compare

• ETS coupling efficiency
• OXPHOS control ratio
• ROUTINE control ratio
• UCR
• RCR

References

1. Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41: 1837–1845.
2. Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopisies of human muscle. Methods Mol Biol 810: 25-58.
3. Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck: 80 pp.