Difference between revisions of "L/E coupling-control ratio"
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{{MitoPedia | {{MitoPedia | ||
|abbr=''L/E'' | |abbr=''L/E'' | ||
|description=The '''LEAK control ratio''', or ''L/E'' coupling control ratio [1,2], is the flux ratio of [[LEAK respiration]] over [[ETS capacity]], as determined by measurement of oxygen consumption in sequentially induced states ''L'' and ''E'' of respiration. The ETS control ratio is an index of [[uncoupling]] or [[dyscoupling]] at constant ETS capacity. ''L/E'' increases with uncoupling from a theoretical minimum of 0.0 for a fully coupled system, to 1.0 for a fully uncoupled system [3]. | |description=[[Image:L over E.jpg|50 px|link=LEAK control ratio|LEAK control ratio]] | ||
The '''LEAK control ratio''', or ''L/E'' coupling control ratio [1,2], is the flux ratio of [[LEAK respiration]] over [[ETS capacity]], as determined by measurement of oxygen consumption in sequentially induced states ''L'' and ''E'' of respiration. The ETS control ratio is an index of [[uncoupling]] or [[dyscoupling]] at constant ETS capacity. ''L/E'' increases with uncoupling from a theoretical minimum of 0.0 for a fully coupled system, to 1.0 for a fully uncoupled system [3]. | |||
|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2014 MitoPathways]] | ||
|type=Respiration | |type=Respiration | ||
Revision as of 13:39, 18 January 2015
- high-resolution terminology - matching measurements at high-resolution
L/E coupling-control ratio
Description
The LEAK control ratio, or L/E coupling control ratio [1,2], is the flux ratio of LEAK respiration over ETS capacity, as determined by measurement of oxygen consumption in sequentially induced states L and E of respiration. The ETS control ratio is an index of uncoupling or dyscoupling at constant ETS capacity. L/E increases with uncoupling from a theoretical minimum of 0.0 for a fully coupled system, to 1.0 for a fully uncoupled system [3].
Abbreviation: L/E
Reference: Gnaiger 2009 Int J Biochem Cell Biol, Gnaiger 2014 MitoPathways
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Compare
- » ETS coupling efficiency, j≈E = 1-L/E = ≈E/E
- » OXPHOS coupling efficiency, j≈P = 1-L/P = ≈P/P
- » ROUTINE coupling efficiency, j≈R = 1-L/R = ≈R/R
- » UCR = E/L
- » RCR = P/L
References
- Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41: 1837–1845.
- Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopisies of human muscle. Methods Mol Biol 810: 25-58.
- Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck: 80 pp.
