Difference between revisions of "L/E coupling-control ratio"
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{{MitoPedia | {{MitoPedia | ||
|abbr=''L/E'' | |abbr=''L/E'' | ||
|description=[[Image:L over E.jpg|50 px|LEAK control ratio]] The '''LEAK control ratio''', or ''L/E'' coupling control ratio [1,2], is the flux ratio of [[LEAK respiration]] over [[ | |description=[[Image:L over E.jpg|50 px|LEAK control ratio]] The '''LEAK control ratio''', or ''L/E'' coupling control ratio [1,2], is the flux ratio of [[LEAK respiration]] over [[ET capacity]], as determined by measurement of oxygen consumption in sequentially induced states ''L'' and ''E'' of respiration. The ET-pathway control ratio is an index of [[uncoupling]] or [[dyscoupling]] at constant ET capacity. ''L/E'' increases with uncoupling from a theoretical minimum of 0.0 for a fully coupled system, to 1.0 for a fully uncoupled system [3]. | ||
|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2014 MitoPathways]] | ||
|type=Respiration | |type=Respiration | ||
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}} | }} | ||
== Compare == | == Compare == | ||
:::» [[ | :::» [[ET-pathway coupling efficiency]], ''j<sub>≈E</sub>'' = 1-''L/E'' = ''≈E/E'' | ||
:::» [[OXPHOS coupling efficiency]], ''j<sub>≈P</sub>'' = 1-''L/P'' = ''≈P/P'' | :::» [[OXPHOS coupling efficiency]], ''j<sub>≈P</sub>'' = 1-''L/P'' = ''≈P/P'' | ||
:::» [[ROUTINE coupling efficiency]], ''j<sub>≈R</sub>'' = 1-''L/R'' = ''≈R/R'' | :::» [[ROUTINE coupling efficiency]], ''j<sub>≈R</sub>'' = 1-''L/R'' = ''≈R/R'' | ||
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== List of publications: LEAK and | == List of publications: LEAK and ET-pathway == | ||
{{#ask:[[Category:Publications]] [[Coupling states::LEAK]] [[Coupling states::ETS]] | {{#ask:[[Category:Publications]] [[Coupling states::LEAK]] [[Coupling states::ETS]] | ||
|?Was published in year=Year | |?Was published in year=Year | ||
Revision as of 16:40, 16 October 2017
- high-resolution terminology - matching measurements at high-resolution
L/E coupling-control ratio
Description
The LEAK control ratio, or L/E coupling control ratio [1,2], is the flux ratio of LEAK respiration over ET capacity, as determined by measurement of oxygen consumption in sequentially induced states L and E of respiration. The ET-pathway control ratio is an index of uncoupling or dyscoupling at constant ET capacity. L/E increases with uncoupling from a theoretical minimum of 0.0 for a fully coupled system, to 1.0 for a fully uncoupled system [3].
Abbreviation: L/E
Reference: Gnaiger 2009 Int J Biochem Cell Biol, Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory control ratio
MitoPedia methods:
Respirometry
Compare
- » ET-pathway coupling efficiency, j≈E = 1-L/E = ≈E/E
- » OXPHOS coupling efficiency, j≈P = 1-L/P = ≈P/P
- » ROUTINE coupling efficiency, j≈R = 1-L/R = ≈R/R
- » UCR = E/L
- » RCR = P/L
References
- Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41: 1837–1845.
- Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopisies of human muscle. Methods Mol Biol 810: 25-58.
- Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck: 80 pp.
