Difference between revisions of "Harmonization"
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|description='''Harmonization''' is the process of minimizing redundant or conflicting [[standard]]s which may have evolved independently. To obtain a common basis in reaching a defined objective, critical [[requirement]]s are identified that need to be retained. | |description='''Harmonization''' is the process of minimizing redundant or conflicting [[standard]]s which may have evolved independently. To obtain a common basis in reaching a defined objective, critical [[requirement]]s are identified that need to be retained. | ||
}} | }} | ||
{ | :::: Harmonization of some terms in mitochondrial physiology links separate 'subcultures' in publication. Ambiguities are pointed out for clarification of concepts. A platform-independent terminology is preferred. See also '''Table 2. Harmonization of terminology on respiratory states'''<ref>Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496. https://doi.org/10.1371/journal.pone.0264496</ref>. | ||
::::: <span style="background:#eaecf0">'''Table 1. Some platform-independent and platform-specific or outdated terms in mitochondrial physiology | |||
::::: {| class="wikitable" | |||
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! Symbol !! Platform-independent terms !! Platform-specific or outdated terms | |||
|- | |||
| ce || [[living cells]] || intact cells | |||
|- | |||
| ''R'' || [[ROUTINE respiration]], in ROUTINE state || [[basal respiration]], in basal state | |||
|- | |||
| ''P'' || [[OXPHOS capacity]], in OXPHOS state of mt-preparations || [[State 3]] | |||
|- | |||
| ''L'' || [[LEAK respiration]] || [[proton leak]]; [[State 4]] | |||
|- | |||
| ''E'' || [[ET capacity]], electron transfer capacity || maximum respiration; State 3u | |||
|- | |||
| ''L/E'' || [[L/E coupling-control ratio |''L/E'' coupling-control ratio]] || 1/UCR = ''L/E'' (ambiguous) | |||
|- | |||
| ''L/P'' || [[L/P coupling-control ratio |''L/P'' coupling-control ratio]] || 1/[[RCR]] = ''L/P'' | |||
|- | |||
| ''R/E'' || [[R/E control ratio |''R/E'' control ratio]] || 1/[[UCR]] = ''E/R'' | |||
|- | |||
| ''R-L'' || [[R-L net ROUTINE capacity |''R-L'' net ROUTINE capacity]], net ROUTINE respiration || ATP production, ATP-linked respiration | |||
|- | |||
| ''E-R'' || [[E-R reserve capacity |''E-R'' reserve capacity]] || spare capacity | |||
|- | |||
| ''Rox'' || [[residual oxygen consumption]], in ROX state || nonmitochondrial respiration; [[State 2]] | |||
|} | |||
{{MitoPedia O2k and high-resolution respirometry | {{MitoPedia O2k and high-resolution respirometry | ||
|mitopedia O2k and high-resolution respirometry=Oroboros QM | |mitopedia O2k and high-resolution respirometry=Oroboros QM | ||
}} | }} | ||
Latest revision as of 14:27, 19 October 2022
- high-resolution terminology - matching measurements at high-resolution
Harmonization
Description
Harmonization is the process of minimizing redundant or conflicting standards which may have evolved independently. To obtain a common basis in reaching a defined objective, critical requirements are identified that need to be retained.
- Harmonization of some terms in mitochondrial physiology links separate 'subcultures' in publication. Ambiguities are pointed out for clarification of concepts. A platform-independent terminology is preferred. See also Table 2. Harmonization of terminology on respiratory states[1].
- Table 1. Some platform-independent and platform-specific or outdated terms in mitochondrial physiology
Symbol Platform-independent terms Platform-specific or outdated terms ce living cells intact cells R ROUTINE respiration, in ROUTINE state basal respiration, in basal state P OXPHOS capacity, in OXPHOS state of mt-preparations State 3 L LEAK respiration proton leak; State 4 E ET capacity, electron transfer capacity maximum respiration; State 3u L/E L/E coupling-control ratio 1/UCR = L/E (ambiguous) L/P L/P coupling-control ratio 1/RCR = L/P R/E R/E control ratio 1/UCR = E/R R-L R-L net ROUTINE capacity, net ROUTINE respiration ATP production, ATP-linked respiration E-R E-R reserve capacity spare capacity Rox residual oxygen consumption, in ROX state nonmitochondrial respiration; State 2
MitoPedia O2k and high-resolution respirometry: Oroboros QM
- ↑ Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496. https://doi.org/10.1371/journal.pone.0264496
