Difference between revisions of "Hanssen 2015 Diabetologia"
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{{Publication | {{Publication | ||
|title=Hanssen MJ, Wierts R, Hoeks J, Gemmink A, Brans B, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD ( | |title=Hanssen MJ, Wierts R, Hoeks J, Gemmink A, Brans B, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2015) Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance. Diabetologia 58:586-95. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/ | |info=[http://www.ncbi.nlm.nih.gov/pubmed/25500952 PMID: 25500952] | ||
|authors=Hanssen MJ, Wierts R, Hoeks J, Gemmink A, Brans B, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD | |authors=Hanssen MJ, Wierts R, Hoeks J, Gemmink A, Brans B, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD | ||
|year= | |year=2015 | ||
|journal=Diabetologia | |journal=Diabetologia | ||
|abstract=Human brown adipose tissue (BAT) has recently | |abstract=Human brown adipose tissue (BAT) has recently | ||
| Line 25: | Line 25: | ||
both cold-induced BAT glucose uptake and | both cold-induced BAT glucose uptake and | ||
nonshivering thermogenesis (NST) during cold stimulation. | nonshivering thermogenesis (NST) during cold stimulation. | ||
In vivo molecular imaging and modelling revealed that the | ''In vivo'' molecular imaging and modelling revealed that the | ||
reduction of glucose uptake in BAT was due to impaired | reduction of glucose uptake in BAT was due to impaired | ||
cellular glucose uptake and not due to decreased supply. | cellular glucose uptake and not due to decreased supply. | ||
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{{Labeling | {{Labeling | ||
|area=Respiration, Exercise physiology;nutrition;life style, Patients | |area=Respiration, Exercise physiology;nutrition;life style, Patients | ||
|diseases=Diabetes | |||
|injuries=Temperature | |||
|organism=Human | |organism=Human | ||
|tissues=Skeletal muscle | |tissues=Skeletal muscle | ||
|preparations=Isolated | |preparations=Isolated mitochondria | ||
|couplingstates=LEAK, ET | |||
|pathways=F | |||
|couplingstates=LEAK | |||
| | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
}} | }} | ||
Latest revision as of 14:31, 13 November 2017
| Hanssen MJ, Wierts R, Hoeks J, Gemmink A, Brans B, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2015) Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance. Diabetologia 58:586-95. |
Hanssen MJ, Wierts R, Hoeks J, Gemmink A, Brans B, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2015) Diabetologia
Abstract: Human brown adipose tissue (BAT) has recently emerged as a potential target in the treatment of type 2 diabetes, owing to its capacity to actively clear glucose from the circulation—at least upon cold exposure. The effects of insulin resistance on the capacity of human BAT to take up glucose are unknown. Prolonged fasting is known to induce insulin resistance in peripheral tissues in order to spare glucose for the brain.
We studied the effect of fasting-induced insulin resistance on the capacity of BAT to take up glucose during cold exposure as well as on cold-stimulated thermogenesis. BAT glucose uptake was assessed by means of cold-stimulated dynamic 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) imaging.
We show that a 54 h fasting period markedly decreases both cold-induced BAT glucose uptake and nonshivering thermogenesis (NST) during cold stimulation. In vivo molecular imaging and modelling revealed that the reduction of glucose uptake in BAT was due to impaired cellular glucose uptake and not due to decreased supply. Interestingly, decreased BAT glucose uptake upon fasting was related to a decrease in core temperature during cold exposure, pointing towards a role for BAT in maintaining normothermia in humans.
Cold-stimulated glucose uptake in BAT is strongly reduced upon prolonged fasting. When cold-stimulated glucose uptake in BAT is also reduced under other insulin-resistant states, such as diabetes, cold-induced activation of BAT may not be a valid way to improve glucose clearance by BAT under such conditions. • Keywords: Brown adipose tissue, Insulin resistance
• O2k-Network Lab: NL Maastricht Schrauwen P
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style, Patients
Pathology: Diabetes
Stress:Temperature
Organism: Human
Tissue;cell: Skeletal muscle
Preparation: Isolated mitochondria
Coupling state: LEAK, ET
Pathway: F
HRR: Oxygraph-2k
