| Gnaiger E, Gellerich FN, Wyss M (1994) What is Controlling Life? 50 years after Erwin Schrödinger's What is Life? Modern Trends in BiothermoKinetics 3, Innsbruck Univ Press, 336 pp. |
Gnaiger E, Gellerich FN, Wyss M (1994) Innsbruck Univ Press
Abstract: Erwin Schrödinger's 'What is Life?' is one of the most influential books of the last century in the biological sciences. It continues to provoke discussions and stimulate interdisciplinary developments in biophysics. Starting with reflections on Schrödinger's famous account of negative entropy in living systems, an international group of scientists presents the latest advancements on the dynamics and control of metabolic processes. This volume of Modern Trends in BioThermoKinetics develops for the first time the explicit link between thermodynamics, metabolic control, bioenergetics and clinical applications.
• O2k-Network Lab: AT_Innsbruck_Gnaiger E
Labels: MiParea: Respiration, mt-Awareness
Coupling state: OXPHOS
HRR: Oxygraph-2k, Theory
CONTENTS: Full Papers
Contents including titles of abstracts: download pdf
- OROBOROS Oxygraph applications
Preface
R. Margreiter. Innsbruck download pdf 13
Trends in Bioenergetics. An Introduction
E. Gnaiger, F.N. Gellerich. Innsbruck download pdf 14
"German Ideology" as seen by Erwin Schrödinger in Letters
to Hans Thirring. From Their Correspondence (1946-1949)
G. Oberkofler, P. Goller. Innsbruck download pdf 19
Part 1
What is Negative Entropy?
From World Views to Bioenergetics
Erwin Schrödinger's World View. The Role of Physics and
Biology in his Philosophical System
J. Götschl. Graz download pdf 23
Science, Art and Revelation
J. Wagensberg. Barcelona download pdf 32
Negentropy and Historical Arrow of Time - Thermodynamical and Informational Aspects of the Darwinian Revolution
G.F. Azzone. Padova download pdf 38
Negative Entropy: Another Approach
C.P. Lantos. Buenos Aires download pdf 45
Schrödinger's What is Life?: The Biophysical Legacy 50 Years Later
G.R. Welch. New Orleans download pdf 48
What is (Schrödinger's) Negentropy?
M.-W. Ho. London download pdf 50
Negative Entropy for Living Systems. Controversy between
Nobel Laureates Schrödinger, Pauling and Perutz
E. Gnaiger. Innsbruck download pdf 62
A Paradigm for Energy Balance in Muscle Function
M.J. Kushmerick. Seattle download pdf 71
A Controlled Chaotic Attractor Controls Life
D. Lloyd. Cardiff download pdf 77
Disease as Instability, Error and Entropy
G.F. Azzone. Padova download pdf 81
Part 2
Control and Regulation: Theory, Models, and Experiment
The Macro- and Microworld of Control Theory
B.N. Kholodenko, H.V. Westerhoff, M. Cascante. Moscow, Amsterdam, Barcelona 88
How Should we Quantify Metabolic Regulation?
J.-H.S. Hofmeyr, A. Cornish-Bowden. Stellenbosch, Marseille 91
Control and Regulation: The Best of Both Worlds
H.V. Westerhoff, P.R. Jensen, J.M. Rohwer, B.N. Kholodenko. Amsterdam, Lyngby, Moscow 95
Evolutionary Optimization of Enzymes on the Basis of
Kinetic and Thermodynamic Principles
R. Heinrich, E. Klipp, A. Stephani, T. Wilhelm, Berlin 99
Detecting Elementary Modes of Functioning in Metabolic Networks
S. Schuster, C. Hilgetag, D.A. Fell. Berlin, Oxford 103
Part 3
Coupling and Mechanisms in the Regulation
of Electron, ATP and Ion Fluxes
Leaks and Slips during Mitochondrial Electron Transfer
S. Luvisetto, M. Canton, I. Schmehl, G.F. Azzone. Padova 122
Experimental Discrimination between Proton Leak
and Redox Slip during Mitochondrial Electron Transport
M.D. Brand, L.-F. Chien, P.H. Diolez. Cambridge, Bordeaux 125
Permeability of the Inner Mitochondrial Membrane and Respiration
M. Canton, S. Luvisetto, I. Schmehl, G.F. Azzone. Padova 129
The Uncoupling Mechanism of the Anesthetic Bupivacaine
I. Schmehl, M. Canton, S. Luvisetto, G.F. Azzone. Padova 133
Influence of the Mechanism of Change in ATP Synthase-ATPase. Stoichiometry on the Control of Oxidative Phosphorylation in situ
X. Leverve, E. Fontaine, P. Espié, C. Keriel, B. Guérin, M. Rigoulet. Grenoble, Bordeaux 137
ATP Synthesis in Permeabilized Cells: Assessment of the
ATP/O Ratios In Situ
R. Ouhabi, M. Boue-Grabot, J.-P. Mazat. Bordeaux 141
Permeabilized Spheroplasts as a Tool for Studying the Mechanistic Stoichiometry of Yeast Oxidative Phosphorylation
V. Fitton, R. Ouhabi, B. Guérin, M. Rigoulet. Bordeaux 145
Investigations upon the Effect of Monovalent Cations on
Oxidative Phosphorylation in Yeast Mitochondria
S. Manon, X. Roucou, M. Guérin. Bordeaux 150
Can Mitochondria Sequester Calcium from Physiological
Calcium Pulses?
G. Sparagna, K.K. Gunter, S.-S. Sheu, T.E. Gunter. Rochester 154
Mitochondrial Calcium Spiking: The Physiological Face of
Permeability Transition?
F. Ichas, L.S. Jouaville, S.S. Sidash, J.-P. Mazat,
E.L. Holmuhamedov. Bordeaux, Pushchino, Kalamazoo 159
Developmental regulation of Na+,K+- and Ca2+-ATPases
in muscle
M.J. Dauncey, T. Clausen, A.P. Harrison. Cambridge, Århus 163
What is controlling the cell membrane potential?
J. Siegenbeek van Heukelom et al. Amsterdam, Moscow 169
Part 4
The Microenvironment of Mitochondria and Cells:
Diffusion Gradients, Shuttles and Signals
ADP Diffusion Gradients and Metabolic Oscillatory Signals
to Mitochondria in Heart and Liver Cells
V.A. Saks, E.V. Vasilyeva, Z.A. Khuchua, Y.O. Belikova, M.K. Aliev, T. Kesvatera, T. Tiivel, K. Anflous, R. Ventura-Clapier, Ch. Keriel, E. Fontaine, X. Leverve. Tallinn, Moscow, Paris, Grenoble 178
Effect of Macromolecules on ADP-Transport into Mitochondria
F.N. Gellerich, F.D. Laterveer, E. Gnaiger, K. Nicolay. Utrecht, Innsbruck download pdf 181*
Macromolecules Increase the Channeling of ADP from Mitochondrially Associated Hexokinase to the Mitochondrial Matrix
F.D. Laterveer, F.N. Gellerich, E. Gnaiger, K. Nicolay. Utrecht, Innsbruck download pdf 186*
How does Oxygen Pressure Control Oxygen Flux in Isolated Mitochondria? A Methodological Approach by High-Resolution Respirometry and Digital Data Analysis
G. Méndez, E. Gnaiger. Innsbruck, Buenos Aires download pdf 191*
Determination of Creatine Kinase Fluxes with Purified Creatine Kinase and Isolated Mitochondria using 31P Nuclear Magnetic Resonance
S. Soboll, A. Conrad, M. Gruwel. Düsseldorf 195
Oscillations of Intracellular pH or High Energy Phosphate Content Cannot be Detected by Gated NMR during the Cardiac Cycle of an Isovolumic Perfused Rat Heart
J.A. Hoerter, B. Gillet, P. Mateo, P. Lechene, J.-C. Beloeil. Chatenay Malabry, Gifs/Yvette 199
Part 5
The Impact of Bioenergetics
on Cellular, Physiological and Biotechnological Processes
Chemical Forces in the Cell: Calculations for the ATP System
E. Gnaiger, M. Wyss. Innsbruck download pdf 207
The Flow-Force Relation of Oxidative Phosphorylation in Human Forearm Muscle is Sigmoidal
J.A.L. Jeneson, S.A. Jubrias, M.J. Kushmerick. Utrecht, Seattle 213
Muscular Contraction, Dissipation and Schrödinger's Negative Entropy
J. Mejsnar, F. Marsík. Praha 215
Modelling of Oxidative Phosphorylation in E. coli
P.R. Jensen, J.M. Rohwer, O. Michelsen, H.V. Westerhoff. Lyngby, Amsterdam 218
Do Oscillations Control the Bacterial Cell Cycle?
I. Fishov. Beer-Sheva 221
A Thermochemical Study of the Production of Lactate by Glutaminolysis and Glycolysis in Mouse Macrophage Hybridoma Cells
R.B. Kemp, S. Hoare, M. Schmalfeldt, C.M.C. Bridge, P.M. Evans, E. Gnaiger. Aberystwyth, Innsbruck download pdf 226
Catabolic Capacity of Carbon- or Nitrogen-Starved Cultures of Saccharomyces cerevisiae
C. Larsson, A. Nilsson, L Gustafsson. Göteborg 232
Energy Allocation and Material Flux in Fish Hepatocytes under Stress
G. Krumschnabel, W. Wieser. Innsbruck 238
Carbon Flux in Lysine Producing Strain Corynebacterium glutamicum MH20-22B: Analysis by 13C-NMR of Amino Acids and Metabolite Balancing
A. Marx, A.A. de Graaf, W. Wiechert, L. Eggeling, H. Sahm. Jülich 240
Remarks on Biocalorimetry and Biothermodynamics Aimed at Characterization of the Physiological State
B. Zentgraf. Furtwangen 244
Part 6
The Impact of Bioenergetics
on Clinical and Pathological Problems
The Permeability Transition Pore. Pathophysiology of a Cyclosporin A-sensitive Mitochondrial Channel
V. Petronilli, A. Nicolli, P. Costantini, R. Colonna, P. Bernardi. Padova 259
Mitochondrial Function in the Atrial Appendage of the Human Heart. Characterization by High-Resolution Respirometry
F.N. Gellerich, R. Steinlechner, M. Wyss, T. Eberl, L.C. Müller, D. Skladal, W. Sperl, O. Dapunt, R. Margreiter, E. Gnaiger. Innsbruck download pdf 263*
Preservation of Mitochondrial Functions in Human Skeletal Muscle during Storage in High Energy Preservation Solution (HEPS)
D. Skladal, W. Sperl, R. Schranzhofer, M. Krismer, E. Gnaiger, R. Margreiter, F.N. Gellerich. Innsbruck download pdf 268*
Application of Control Analysis to the Study of Metabolic Diseases in Mitochondria. Metabolic Expression of Mitochondrial DNA Mutations
J.-P. Mazat, T. Letellier, M. Malgat, S. Jouaville, R. Morkuniene. Bordeaux, Kaunas 272
Change in Flux Control Coefficient of Cytochrome c Oxidase in Copper Deficient Mottled Brindled Mice
A.V. Kuznetsov, J.F. Clark, K. Winkler, W.S. Kunz. Magdeburg, Oxford download pdf 275*
Insulin-Dependent Diabetes Mellitus in MELAS-Mitochondriopathy: Discussion of Possible Causal Relations
K. Oexle, J. Oberle, C. Hübner 278
Simulation of the Flow-Force Relation of Oxidative Phosphorylation in Complex I Deficiency
J.A.L. Jeneson, H.V. Westerhoff. Utrecht, Amsterdam 280
Oxygen Dependence of Cellular Respiration in Endothelial Cells: A Sensitive Toxicological Test
R. Steinlechner, T. Eberl, R. Margreiter, E. Gnaiger. Innsbruck download pdf 283*
Endothelial Cell Cultures as a Model for Organ Preservation Studies
T. Eberl, R. Steinlechner, W. Salvenmoser, B. Abendstein, M. Rhomberg, H. Schröcksnadel, T. Schmid, E. Gnaiger, R. Margreiter. Innsbruck download pdf 288*
The Effect of 2-Chlorodeoxyadenosine on Endogenous Respiration of a Human Lymphoma Cell line (U-937)
A. Knoblechner, R. Steinlechner, M. Schirmer, F.N. Gellerich, R. Margreiter, G. Konwalinka, E. Gnaiger. Innsbruck download pdf 294*
Part 7
Computer Software for Bioenergetics
and Metabolic Control Analysis
Simultaneous Estimates of Single-Enzyme Kinetic Parameters for Multi-Enzymatic Systems Using Artificial Neural Networks
P. Mendes, D.B. Kell. Aberystwyth 302
Design of a Software Framework for Flux Determination by 13C NMR Isotope Labelling Experiments
W. Wiechert. Jülich 305
Announcements
Oroboros. Grinzens-Innsbruck, Austria download pdf 316
Acknowledgements for Financial Support 318
Index
Subject Index 319
Author Index 325
Addresses of Participants 329
