Difference between revisions of "Glycerophosphate shuttle"

Latest revision as of 19:37, 1 January 2021

high-resolution terminology - matching measurements at high-resolution

Glycerophosphate shuttle

Description

The glycerophosphate shuttle makes cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophosphate dehydrogenase. On the outer face of the inner mitochondrial membrane, glycerophosphate dehydrogenase complex (mitochondrial glycerophosphate dehydrogenase) oxidizes glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein transfers its reducing equivalents into the Q-junction, thus representing a ET pathway level 3 control state.

Abbreviation: Gp shuttle

Reference: Gnaiger 2020 BEC MitoPathways

MitoPedia topics: Enzyme

@@ Line 1: / Line 1: @@
 {{MitoPedia
 |abbr=Gp shuttle
-|description=the '''glycerophosphate shuttle''' makes cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophosphate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidizes glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the [[electron transfer system]] at the level of [[CoQ]].
+|description=[[File:Gp-shuttle.jpg|left|200px|Gp]]
-|info=[[MiPNet11.09]]
+The '''glycerophosphate shuttle''' makes cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophosphate dehydrogenase. On the outer face of the inner mitochondrial membrane, [[glycerophosphate dehydrogenase complex]] (mitochondrial glycerophosphate dehydrogenase) oxidizes glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein transfers its reducing equivalents into the [[Q-junction]], thus representing a [[Electron-transfer-pathway state|ET pathway level 3 control state]].
-|type=Enzyme
+|info=[[Gnaiger 2020 BEC MitoPathways]]
 }}
-{{Labeling
+{{MitoPedia topics
-|enzymes=TCA Cycle and Matrix Dehydrogenases, Inner mtMembrane Transporter
+|mitopedia topic=Enzyme
 }}