Difference between revisions of "Glycerophosphate shuttle"
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|abbr=Gp shuttle | |abbr=Gp shuttle | ||
|description=[[File:Gp-shuttle.jpg|left|200px|Gp]] | |description=[[File:Gp-shuttle.jpg|left|200px|Gp]] | ||
The '''glycerophosphate shuttle''' makes cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophosphate dehydrogenase. On the outer face of the inner mitochondrial membrane, [[glycerophosphate dehydrogenase complex]] (mitochondrial glycerophosphate dehydrogenase) oxidizes glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein transfers its reducing equivalents into the [[Q-junction]], thus representing a [[ | The '''glycerophosphate shuttle''' makes cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophosphate dehydrogenase. On the outer face of the inner mitochondrial membrane, [[glycerophosphate dehydrogenase complex]] (mitochondrial glycerophosphate dehydrogenase) oxidizes glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein transfers its reducing equivalents into the [[Q-junction]], thus representing a [[Electron transfer-pathway state|ET pathway level 3 control state]]. | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
}} | }} | ||
Revision as of 09:31, 20 October 2017
- high-resolution terminology - matching measurements at high-resolution
Glycerophosphate shuttle
Description
The glycerophosphate shuttle makes cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophosphate dehydrogenase. On the outer face of the inner mitochondrial membrane, glycerophosphate dehydrogenase complex (mitochondrial glycerophosphate dehydrogenase) oxidizes glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein transfers its reducing equivalents into the Q-junction, thus representing a ET pathway level 3 control state.
Abbreviation: Gp shuttle
Reference: Gnaiger 2014 MitoPathways
MitoPedia topics:
Enzyme
