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|description=[[File:E.jpg]] '''ET-capacity''' is the respiratory [[electron transfer | |description=[[File:E.jpg]] '''ET-capacity''' is the respiratory [[electron transfer pathway]] capacity, ''E'', of mitochondria measured as oxygen consumption in the noncoupled state at optimum [[uncoupler]] concentration. This optimum concentration is obtained by stepwise titration of an established protonophore to induce maximum oxygen flux as the determinant of ET-capacity. Β | ||
[[Electron transfer | [[Electron transfer pathway]] capacity determined in intact cells is typically lower than that inducible in permeabilized cells. The reason is that in the latter substrates are normally provided at (near-)saturating conditions, whereas in intact cells respiration is fuelled by endogenous substrates possibly supplemented with external substrates the uptake of which is limited by the activity of cell membrane transporting pathways. | ||
For a more comprehensive account see [[ET-capacity]]. | For a more comprehensive account see [[ET-capacity]]. |
Revision as of 14:28, 8 June 2020
{{MitoPedia |abbr=E |description= ET-capacity is the respiratory electron transfer pathway capacity, E, of mitochondria measured as oxygen consumption in the noncoupled state at optimum uncoupler concentration. This optimum concentration is obtained by stepwise titration of an established protonophore to induce maximum oxygen flux as the determinant of ET-capacity.
Electron transfer pathway capacity determined in intact cells is typically lower than that inducible in permeabilized cells. The reason is that in the latter substrates are normally provided at (near-)saturating conditions, whereas in intact cells respiration is fuelled by endogenous substrates possibly supplemented with external substrates the uptake of which is limited by the activity of cell membrane transporting pathways.
For a more comprehensive account see ET-capacity.