Volt 2014 Abstract The 2014 Ageing Summit

From Bioblast
Effects of melatonin on the age-dependent dysregulation of the Nf-Kb/Nlrp3 activation during sepsis.


Volt H, Doerrier C, Garcia JA, Lopez LC, Escames G, Acuna-Castroviejo D (2014)

Event: The 2014 Ageing Summit

The age-related changes of the immune system involve a persistent proinflammatory state. This subclinical and chronic inflammation contributes further to enhance the susceptibility of the elderly patients to several acute and chronic inflammatory diseases, including sepsis and ageing itself. The recent discovery of the NF-kB/NLRP3 connection during the innate immune response to inflammatory signals leads to explore the activation of this pathway during ageing in a mouse model of sepsis. The lack of an effective treatment of this disease supports the look for new molecular targets and/or drug therapy. We explored whether the anti-inflammatory actions of melatonin can protects against NF-kB/NLRP3 activation. Our results support NLRP3 inflammasome as a novel molecular signaling pathway during sepsis and indentify it as a main target for the anti-inflammatory action of melatonin. Due to the age-dependent reduction in the endogenous melatonin production, the relation between melatonin reduction and increased inflammatory response with age is discussed.

O2k-Network Lab: ES Granada Acuna-Castroviejo D

Labels: MiParea: Respiration  Pathology: Aging;senescence, Sepsis  Stress:Oxidative stress;RONS  Organism: Mouse  Tissue;cell: Heart  Preparation: Permeabilized tissue 

Pathway: N, S, NS  HRR: Oxygraph-2k  Event: Oral 


1-Instituto de Biotecnología, Centro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Avda. Del Conocimiento s/n, 18100 Armilla, Granada, Spain. 2-Departamento de Fisiología, Facultad de Medicina,Universidad de Granada, Avenida de Madrid 11, 18012 Granada, Spain. 3-Unidad de Gestión Clínica de Laboratorios Clínicos, Hospital Universitario San Cecilio, Avenida Dr. Olóriz s/n, 18012 Granada, Spain.

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