Talk:Electron-transfer-pathway state

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Terminology: from CI- and CII-linked to N and S

                   CI and CII are abbreviations for enzymes (Should we keep calling like that?), respiratory Complex I (CI) and Complex II (CII).
                   In Gnaiger 2009, the 2007-2014 editions of MitoPathways and many previous publications, CI-linked respiration has been used to indicate respiration supported by NADH-generating substrates, N (pyruvate, glutamate, malate, or other ET-pathway competent N-type substrate combinations). In this N-pathway, electron transfer converges from dehydrogenases to the NADH-junction, and from NADH through CI to the Q-junction, with further electron transfer through CIII and CIV to oxygen. Similarly, CII-linked respiration indicates respiration supported by succinate, S, and electron transfer through CII to the Q-junction, with further electron transfer through CIII and CIV to oxygen.
                   Convergent electron flow from a combination of NADH-generating substrates (N) and succinate (S) has been previously indicated as CI&II-linked respiration (Gnaiger 2014 MitoPathways), synonymous with NS. The symbol '&' in CI&II helps to distinguish CI&II as the measured flux in the presence of both NADH-linked substrates and succinate, in contrast to CI+CII (or N+S) as the algebraic sum of fluxes measured separately in the N- versus S-pathway control states.
                   Simplification: NS denotes flux under the simultaneous control of the NADH- and succinate-linked pathways (NS-substrate cocktail), in contrast to N+S as the algebraic sum of the fluxes controlled by the two pathways separately.


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