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...P Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC (2016) Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. J Lipi ...ell death is driven by mitochondrial targeting and ROS generation and that tamoxifen enhances the ceramide effect by blocking its metabolism. As depletion of AT

...Huttl M, Hubackova SS, Haluzik M, Neuzil J (2022) Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice. https:/ ...e metabolic dysfunction. Targeting senescence with mitochodrially targeted tamoxifen thus represents an approach to the treatment of type 2 diabetes mellitus an

|title=Mitochondrial targeting of tamoxifen enhances its activity against Her2^high breast cancer. ...=Mitochondria play a crucial role for apoptosis induction in cancer cells. Tamoxifen is an established anti-cancer agent used primarily against hormone-dependen

...to MitoTam, a novel mitochondria-targeted derivative of tamoxifen. Unlike tamoxifen, MitoTam efficiently eradicates experimental Her2^high tumors wit |keywords=Electron transport chain, Supercomplexes, Tamoxifen, Complex I, Her2, Human breast cancer MCF7 cells

...pe [WT]) littermates using a Cre-LoxP approach. All mice were treated with tamoxifen at 5-6 weeks of age and 4-7 weeks later we assessed glucose homeostasis, sk

...acity (CRC). Progesterone, trifluoperazine, allopregnanolone and 4-hydroxy-tamoxifen dose-dependently reduced CRC and respiratory control and were thus toxic ra

|keywords=Glucose uptake, Insulin signaling, Respirometry, Tamoxifen

...gulation and function of FOXO3 by expressing an ECFP-tagged FOXO3 or a 4OH-tamoxifen (4OHT)-inducible FOXO3-ERtm fusion protein in SH-EP and STA-NB15 neuronal c

...and indirect effects of post-gestational AHR deficiency. Utilizing a novel tamoxifen-inducible AHR knockout mouse model, we analyzed the effects of hepatocyte-t

...ing in the cytosol. Breeding the RISP mice with transgenic mice expressing tamoxifen-activated Cre in smooth muscle permitted the depletion of RISP in PASMC in

...the anti-cancer drug candidate MitoTam, a mitochondria-targeted analog of tamoxifen, efficiently eliminates a wide range of evolutionarily distinct pathogens '

...α1 and α2 subunits) AMPK deletion was obtained in a model of a conditional tamoxifen-inducible KO mouse. Experiments were carried out with heart mitochondria, i

...and α2 subunits) AMPK deletion was obtained in a model of a conditional [[tamoxifen]]-inducible KO mouse. Experiments were carried out with heart mitochondria,

...ion against apoptosis. In the present study, we generated cardiac-specific tamoxifen-inducible NDUFA13 knockout mice and demonstrated that cardiac-specific hete

...atrophy, we treated young (2- to 4-month-old) Sod1flox/SlickHCre mice with tamoxifen to generate i-mn-Sod1KO mice. CuZnSOD protein was 40-50% lower in neuronal

Tamoxifen-inducible and muscle-specific AMPKα1/α2 double KO mice (AMPKα imdKO) wer

...assessed using the radial arm water maze in young and old mice as well as tamoxifen-inducible astrocyte-specific knockout of IGFR (GFAP-Cre^TAM/igfr<

To obtain adult ''Tmem70-/-'' mice, we further generated tamoxifen (TAM) inducible knockout. Upon induction of Cre-mediated excision, the weig

...sed (Sohal et al., 2001). Heart-specific AMPK deletion will be achieved by tamoxifen administration in adult mice to avoid any developmental defect or compensat ...issue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible cre protein. 2001 Circulation research 89, 20-25 Kuznetsov A V, V