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Umbrasas 2019 MitoFit Preprint Arch EA
Additional label Preprints  +
Has abstract Version 1 ('''v1''') '''2019-06-03''' [htt
Version 1 ('''v1''') '''2019-06-03''' [http://www.mitofit.org/images/e/e9/Umbrasas_2019_MitoFit_Preprint_Arch_doi_10.26124mitofitEA19.MiPSchool.0001.pdf doi:10.26124/mitofit:ea19.MiPSchool.0001] Itaconic acid (IA) is a recently discovered mammalian metabolite which is produced by macrophages upon pro-inflammatory activation: in quiescent bone marrow – derived macrophages (BMDMs). IA is hardly detectable but upon lipopolysaccharide (LPS) stimulation it reaches millimolar concentrations [1]. Recently reported physiological roles of IA include inhibition of bacterial enzyme isocitrate lyase (bactericidal activity) and the inhibition of a Krebs cycle enzyme succinate dehydrogenase (SDH) in the host cells (which has been shown for BMDMs) [2,3]. By inhibiting SDH, IA regulates succinate (a pro-inflammatory metabolite) levels thus remodelling the host cells metabolism during inflammation [3]. Microglia are macrophages residing in the brain, however, it is not clear whether these cells can also produce IA. In general, there has been very little research on IA effects on brain tissue. Therefore, in this study, we investigated whether IA exerts an effect on brain mitochondrial respiration and ROS generation and whether IA is neurotoxic.
S generation and whether IA is neurotoxic.  +
Has editor [[Iglesias-Gonzalez J]]  +
Has info [[File:MitoFit Preprint Arch pdf.png|left|
[[File:MitoFit Preprint Arch pdf.png|left|160px|link=http://www.mitofit.org/images/e/e9/Umbrasas_2019_MitoFit_Preprint_Arch_doi_10.26124mitofitEA19.MiPSchool.0001.pdf |MitoFit pdf]] <big><big>'''[http://www.mitofit.org/images/e/e9/Umbrasas_2019_MitoFit_Preprint_Arch_doi_10.26124mitofitEA19.MiPSchool.0001.pdf Itaconic acid decreases mitochondrial respiration and ROS generation in brain tissue]'''</big></big> <br />
e]'''</big></big> <br />  +
Has publicationkeywords [[TCA cycle]]  +
Has title Umbrasas Danielius, Vanagas T, Cizas P, Borutaite V (2019) Itaconic acid decreases mitochondrial respiration and ROS generation in brain tissue. MitoFit Preprint Arch [[doi:10.26124/mitofit:ea19.MiPSchool.0001]].  +
Was published by MiPNetLab LT Kaunas Borutaite V +
Was published in journal MitoFit Preprint Arch +
Was published in year 2019  +
Was written by Vanagas T + , Cizas P + , Borutaite V + , Umbrasas D +
Display title of
"Display title of" is a predefined property that can assign a distinct display title to an entity and is provided by Semantic MediaWiki.
Umbrasas 2019 MitoFit Preprint Arch EA  +
Categories MitoFit , Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
07:10:02, 19 June 2019  +
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