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Schoepf 2019 MitoFit Preprint Arch
Additional label MitoEAGLEPublication  +
Coupling states ET  + , LEAK  + , OXPHOS  +
Diseases Cancer  +
Enzyme Complex I  + , TCA cycle and matrix dehydrogenases  +
Has abstract '''2019-12-23 Accepted for publication in
'''2019-12-23 Accepted for publication in ''NATURE Communications'' pending editorial revision.''' Version 1 ('''v1''') '''2019-06-11''' [ doi:10.26124/mitofit:190003] Rewiring of energy metabolism and adaptation of mitochondrial respiratory functions are considered to impact on prostate cancer development and progression. High-resolution respirometry of paired benign and malignant human prostate tissue samples revealed reduced respiratory capacities with NADH-pathway substrates glutamate and malate in malignant tissue and a significant metabolic shift towards respiratory capacity with succinate, particularly in high-grade tumors. The load of potentially deleterious mitochondrial-DNA mutations was higher in tumor tissue and associated with unfavorable risk factors. High levels of potentially deleterious mutations in mitochondrial Complex I-encoding genes were associated with a 70% reduction in NADH-pathway capacity and compensation by increased S-pathway capacity. Structural analyses of these mutations revealed amino acid alterations leading to potentially deleterious effects on Complex I, supporting a causal relationship. RNA-seq revealed a signature of metabolic enzymes corresponding to the altered mitochondrial respiratory pathways and enabled extraction of a metagene set for prediction of shorter disease-free survival.
ediction of shorter disease-free survival.  +
Has editor [[Gnaiger E]]  +
Has info [[File:MitoFit Preprint Arch pdf.png|left|
[[File:MitoFit Preprint Arch pdf.png|left|160px|link= |MitoFit pdf]] <big><big>'''[ OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature]'''</big></big> <br />
e]'''</big></big> <br />  +
Has publicationkeywords Mitochondria  + , high-resolution respirometry  + , metabolic reprograming  + , mitochondrial DNA mutation  + , mtDNA heteroplasmy  + , oxidative phosphorylation  +
Has title Schöpf B, Weissensteiner H, Schäfer G, Faz
Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Eichelbrönner I, Sorn P, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2019) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature. MitoFit Preprint Arch [[doi:10.26124/mitofit:190003]].
rint Arch [[doi:10.26124/mitofit:190003]].  +
Instrument and method Oxygraph-2k  +
Mammal and model Human  +
MiP area Respiration  + , mt-Medicine  + , mtDNA;mt-genetics  + , nDNA;cell genetics  +
Pathways F  + , N  + , NS  + , ROX  + , S  +
Preparation Permeabilized tissue  +
Stress Oxidative stress;RONS  +
Tissue and cell Genital  +
Was published by MiPNetLab AT Innsbruck Oroboros + , AT Innsbruck Gnaiger E +
Was published in journal MitoFit Preprint Arch +
Was published in year 2019  +
Was written by Schoepf B + , Weissensteiner H + , Schaefer G + , Fazzini F + , Charoentong P + , Naschberger A + , Rupp B + , Fendt L + , Bukur V + , Eichelbroenner I + , Sorn P + , Sahin U + , Kronenberg F + , Gnaiger E + , Klocker H +
Display title of
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Schoepf 2019 MitoFit Preprint Arch  +
Categories Publications , MitoFit
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
12:30:07, 23 December 2019  +
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