Schrauwen-Hinderling 2015 Antioxid Redox Signal

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Schrauwen-Hinderling VB, Kooi ME, Schrauwen P (2015) Mitochondrial function and diabetes; consequences for skeletal and cardiac muscle metabolism. Antioxid Redox Signal 24:39-51.

» PMID:25808308

Schrauwen-Hinderling VB, Kooi ME, Schrauwen P (2015) Antioxid Redox Signal

Abstract: An early hallmark in the development of type 2 diabetes is the resistance to the effect of insulin in skeletal muscle and in the heart. Since mitochondrial function was found to be diminished in patients with type 2 diabetes, it was suggested that this defect might be involved in the etiology of insulin resistance. Although several hypotheses were suggested, yet unclear is the mechanistic link between these two phenomena.

Herein, we review the evidence for disturbances in mitochondrial function in skeletal muscle and the heart in the diabetic state. Also the mechanisms involved in improving mitochondrial function are considered and, whenever possible, human data is cited. Reported evidence shows that interventions that improve skeletal muscle mitochondrial function also improve insulin sensitivity in humans. In the heart, available data from animal studies suggests that enhancement of mitochondrial function can reverse aging-induced changes in heart function, and can be protective against cardiomyopathy and heart failure.

Mitochondria and their functions can be targeted with the aim of improving skeletal muscle insulin sensitivity and cardiac function. However, human clinical intervention studies are needed to fully substantiate the potential of mitochondria as a target to prevent cardiometabolic disease.

Keywords: Review

O2k-Network Lab: NL Maastricht Schrauwen P


Labels: MiParea: Respiration  Pathology: Diabetes, Other 

Organism: Human  Tissue;cell: Heart, Skeletal muscle  Preparation: Permeabilized tissue, Isolated mitochondria  Enzyme: Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Uncoupling protein 

Coupling state: LEAK, OXPHOS  Pathway: F, N, S, CIV  HRR: Oxygraph-2k