Qingxian 2020 Lancet

From Bioblast
Publications in the MiPMap
Qingxian Cai, Chen Fengjuan, Fang Luo, Xiaohui Liu, Tao Wang, Qikai Wu, Qing He, Zhaoqin Wang, Yingxia Liu, Jun Chen, Lei Liu, Lin Xu (2020) Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. Lancet Preprint at SSRN https://doi.org/10.2139/ssrn.3556658.

Lancet Open Access

Qingxian Cai, Chen Fengjuan, Fang Luo, Xiaohui Liu, Tao Wang, Qikai Wu, Qing He, Zhaoqin Wang, Yingxia Liu, Jun Chen, Lei Liu, Lin Xu (2020) Lancet

Abstract: Background: Patients with obesity are at increased risk of exacerbations from viral respiratory infections. However, the association of obesity with severity of corona virus disease 2019 (COVID-19) is unclear. We hereby examined this association using data from the only referral hospital in Shenzhen, China.

Methods: 383 COVID-19 patients admitted from 11 January to 16 February 2020 in the Third People鈥檚 Hospital of Shenzhen, China were included. Underweight was defined by body mass index (BMI) lower than 18路5 kg/m2, normal weight by 18路5-23路9 kg/m2 , overweight by 24路0- 27路9 kg/m2 and obesity as 鈮28 kg/m2.

Findings: Of them, 53路1 % were normal weight, 4路2 % were underweight, 32路0 % were overweight, and 10路7 % were obese. Patients with obesity, versus without, were tended to have cough (P=0路03) and fever (P=0路06). After adjusting for potential confounders, compared to normal weight, overweight showed 86 % higher, and obesity group showed 2路42-fold higher odds of developing severe pneumonia. Despite a non-significant sex interaction was found (P=0路09), the association appeared to be more pronounced in men than in women. The odds ratios (95 % confidence intervals) for severe pneumonia in overweight and obesity was 1路96 (0路78-4路98) and 5路70 (1路83-17路76) in men, and 1路51 (0路57-4路01) and 0路71 (0路07-7路3) in women, respectively.

Interpretation: This is the first study showing that obesity, especially in men, significantly increases the risk of developing severe pneumonia in COVID-19 patients. As the 2019n-Cov may continue to spread worldwide, clinicians should maintain a high level of attention in obese patients. Obese patients should be carefully managed with prompt and aggressive treatment.

Bioblast editor: Gnaiger E


Labels: MiParea: Gender, Patients  Pathology: Infectious, Obesity 

Organism: Human 

Preparation: Intact organism 




Comorbidity, BMI, mitObesity2020, Virus 

Cookies help us deliver our services. By using our services, you agree to our use of cookies.