PGMS pathway control state

From Bioblast
(Redirected from PGMS)
Jump to: navigation, search
Bioblasts - Richard Altmann and MiPArt by Odra Noel
MitoPedia         Terms and abbreviations         Concepts and methods         MitoPedia: SUIT         MiP and biochemistry         Preprints and history



MitoPedia

PGMS pathway control state

Description

PGMS
PGMS: Pyruvate & Glutamate & Malate & Succinate.

MitoPathway control state: NS-pathway control state

2-oxoglutarate is produced through the citric acid cycle from citrate by isocitrate dehydrogenase, from oxaloacetate and glutamate by the transaminase, and from glutamate by the glutamate dehydrogenase. If the 2-oxoglutarate carrier does not outcompete these sources of 2-oxoglutarate, then the TCA cycle operates in full circle with external pyruvate&malate&glutamate&succinate

Abbreviation: PGMS

Reference: Gnaiger 2014 MitoPathways - Chapter 5.6


MitoPedia concepts: SUIT state 

More details
» NS-pathway control state
» Additive effect of convergent electron flow
» Respiratory complexes - more than five
» Convergent electron flow


PGMSL

PGMS pathway in the LEAK state can be evaluated in the following SUIT protocols:


PGMSP

PGMS pathway in the OXPHOS state can be evaluated in the following SUIT protocols:

PGMSE

PGMS pathway in the ET state can be evaluated in the following SUIT protocols:

Discussion

Recent studies showed that S- and NS-linked OXPHOS capacity is inhibited by 2 mM malate concentrations as applied in many SUIT protocols. This inhibition is less pronounced at higher succinate concentrations (10 mM up to 50 mM S).