From Bioblast
- high-resolution terminology - matching measurements at high-resolution
Obesity
Description
Obesity is a disease resulting from excessive accumulation of body fat. In common obesity (non-syndromic obesity) excessive body fat is due to an obesogenic lifestyle with lack of physical exercise ('couch') and caloric surplus of food consumption ('potato'), causing several comorbidities which are characterized as preventable non-communicable diseases. Persistent body fat excess associated with deficits of physical activity induces a weight-lifting effect on increasing muscle mass with decreasing mitochondrial capacity. Body fat excess, therefore, correlates with body mass excess up to a critical stage of obesogenic lifestyle-induced sarcopenia, when loss of muscle mass results in further deterioration of physical performance particularly at older age.
Reference: Haslam 2007 Obes Rev, Body mass excess
 |
Healthy reference population | Body mass excess | BFE | BME cutoffs | BMI | H | M | VO2max | mitObesity drugs |
Obesity as a preventable mitochondrial disease
Work in progress by Gnaiger E 2020-02-14 linked to a preprint in preparation on BME and mitObesity.
- It is very injurious to health to take in more food than the constitution will bear, when, at the same time one uses no exercise to carry off this excess. (Hippocrates ∼400 BC De Flatibus; in Haslam 2007 Obes Rev)
- "Uniquely among chronic diseases, lack of scientific knowledge is not a barrier to the successful treatment of a person who is obese. .. We already know enough about the causes and how to manage it by diet, activity, drugs and surgery" (Haslam 2007 Obes Rev). - Based on this paradigm, the world record attests to a continuing failure of combatting the further spread of the obesity pandemic (Apovian 2016 Am J Manag Care, NCD-RisC 2017 Lancet). Apart from further insights into the genetic basis of common obesity (Walley 2009 Nat Rev Genet), current lack of scientific knowledge hinders successful obesity prevention strategies:
- The common mechanisms leading from obesity to its associated comorbidities are still little understood. This is one among a diversity of reasons that limited or limits acceptance of obesity as a disease. Why prevent obesity if it is not understood as a disease? Most physicians and patients are unaware that mitochondria — the tiny powerhouses in our cells — are at the forefront of comorbidities in the obesity pandemic, linking common obesity to a variety of preventable degenerative diseases. Understanding these mechanisms will not directly prevent obesity, but it will help.
- Inaccurate measures of obesity based on BMI cutoffs render a large part of the population wrongly diagnosed as normal-weight (or non-obese) and on the other hand wrongly diagnosed as overweight (or obese). Failure of proper diagnosis in the normal-to-overweight greyzone presents a first barrier against objective prevention strategies.
- The state of the disease of obesity is communicated to the patients as a number (BMI), which lacks an intuitively clear message. What does it mean when your BMI changed from 20 to 30 from age of 13 to 18, or from 26 to 30 from age 18 to 28? Can everybody translate a daily measure of body mass on a fairly well calibrated balance in the bathroom into an index of obesity? It will make a difference if I know that for my height of 1.7 m a body mass of 79.3 kg means that I am only 1.5 kg away from obesity, and obesity means that I have a body mass excess, BME, of 0.4 or 40 % above my reference body mass of 57.7 kg.
- "Uniquely among chronic diseases, lack of scientific knowledge is not a barrier to the successful treatment of a person who is obese. .. We already know enough about the causes and how to manage it by diet, activity, drugs and surgery" (Haslam 2007 Obes Rev). - Based on this paradigm, the world record attests to a continuing failure of combatting the further spread of the obesity pandemic (Apovian 2016 Am J Manag Care, NCD-RisC 2017 Lancet). Apart from further insights into the genetic basis of common obesity (Walley 2009 Nat Rev Genet), current lack of scientific knowledge hinders successful obesity prevention strategies:
- References
- Apovian CM (2016) Obesity: definition, comorbidities, causes, and burden. Am J Manag Care 22(7 Suppl):s176–85. - »Bioblast link«
- Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, OBruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48:16–31. - »Bioblast link«
- Haslam D (2007) Obesity: a medical history. Obes Rev 8 Suppl 1:31-6. - »Bioblast link«
- NCD Risk Factor Collaboration (NCD-RisC) (2017) Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet 390:2627–42. - »Bioblast link«
- Walley AJ, Asher JE, Froguel P (2009) The genetic contribution to non-syndromic human obesity. Nat Rev Genet 10:431–42. - »Bioblast link«
- References
References: Obesity
- - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
Sort in ascending/descending order by a click on one of the small symbols in squares below. Default sorting: chronological. Empty fields appear first in ascending order.
| Year | Reference | Organism | Tissue;cell | |
|---|---|---|---|---|
| Allerton 2024 Sci Rep | 2024 | Allerton TD, Stampley JE, Li Z, Yu X, Quiariate H, Doiron JE, White G, Wigger Z, Gartia MR, Lefer DJ, Soto P, Irving BA (2024) Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer's model. Sci Rep 14:26118. https://doi.org/10.1038/s41598-024-75870-8 | Mouse | Nervous system |
| Shirakawa 2024 Sci Rep | 2024 | Shirakawa R, Nakajima T, Yoshimura A, Kawahara Y, Orito C, Yamane M, Handa H, Takada S, Furihata T, Fukushima A, Ishimori N, Nakagawa M, Yokota I, Sabe H, Hashino S, Kinugawa S, Yokota T (2024) Author Correction: Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults. Sci Rep 14:6786. https://doi.org/10.1038/s41598-024-57171-2. Erratum for: Sci Rep. 2023 13:5203. https://doi.org/10.1038/s41598-023-32549-w | Human | Blood cells |
| Kahl 2024 J Hepatol | 2024 | Kahl S, Straßburger K, Pacini G, Trinks N, Pafili K, Mastrototaro L, Dewidar B, Sarabhai T, Trenkamp S, Esposito I, Schlensak M, Granderath FA, Roden M (2024) Dysglycemia and liver lipid content determine the relationship of insulin resistance with hepatic OXPHOS capacity in obesity. J Hepatol [Epub ahead of print]. https://doi.org/10.1016/j.jhep.2024.08.012 | Human | Liver |
| Jardon 2024 Gut Microbes | 2024 | Jardon KM, Goossens GH, Most J, Galazzo G, Venema K, Penders J, Blaak EE (2024) Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity. Gut Microbes 16:2392875. https://doi.org/10.1080/19490976.2024.2392875 | Human | Skeletal muscle |
| Zhang 2024 Cell Metab | 2024 | Zhang Y, Higgins CB, Tica S, Adams JA, Sun J, Kelly SC, Zong X, Dietzen DJ, Pietka T, Ballentine SJ, Shriver L, Patti G, Cao Y, DeBosch BJ (2024) Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism. Cell Metab [Epub ahead of print]. https://doi.org/10.1016/j.cmet.2024.07.007 | Mouse | Liver |
| Alvarez-Luis 2024 MitoFit | 2024 | Alvarez-Luis J, Gama-Perez P, Garcia-Roves PM (2024) Exploring Mitochondrial Adaptability: Key to Overcoming Obesity and Enhancing Metabolic Health. MitoFit Preprints 2024.5. https://doi.org/10.26124/mitofit:2024-0005 | ||
| Jiang 2024 Nat Metab | 2024 | Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG (2024) Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nat Metab [Epub ahead of print]. https://doi.org/10.1038/s42255-024-01038-3 | Mouse | Liver |
| Xia 2024 Nat Metab | 2024 | Xia W, Veeragandham P, Cao Y, Yayun Xu Y, Rhyne TE, Qian J, Hung C-W, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR (2024) Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Nat Metab 6:273–89. https://doi.org/10.1038/s42255-024-00978-0 | Human Mouse | Fat |
| National Academies of Sciences, Engineering, and Medicine 2024 Body composition and obesity | 2024 | National Academies of Sciences, Engineering, and Medicine (2024) Exploring the science on measures of body composition, body fat distribution, and obesity. National Academies Press, Washington, DC https://doi.org/10.17226/27461. | Human | Fat |
| Ravera 2023 Cells | 2023 | Ravera S, Signorello MG, Panfoli I (2023) Platelet metabolic flexibility: a matter of substrate and location. Cells 12:1802. https://doi.org/10.3390/cells12131802 | Human | Blood cells Platelet |
| Heo 2023 J Cachexia Sarcopenia Muscle | 2023 | Heo J, Schifino AG, McFaline-Figueroa J, Miller DL, Hoffman JR, Noble EE, Greising SM, Call JA (2023) Differential effects of Western diet and traumatic muscle injury on skeletal muscle metabolic regulation in male and female mice. https://doi.org/10.1002/jcsm.13361 | Mouse | Skeletal muscle |
| National Academies of Sciences, Engineering, and Medicine 2023 BMI and beyond | 2023 | National Academies of Sciences, Engineering, and Medicine (2023) BMI and beyond: Considering context in measuring obesity and its applications: Proceedings of a workshop—in brief. The National Academies Press, Washington, DC. https://doi.org/10.17226/27185 | Human | Fat |
| Dewidar 2023 EBioMedicine | 2023 | Dewidar B, Mastrototaro L, Englisch C, Ress C, Granata C, Rohbeck E, Pesta D, Heilmann G, Wolkersdorfer M, Esposito I, Reina Do Fundo M, Zivehe F, Yavas A, Roden M (2023) Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases. https://doi.org/10.1016/j.ebiom.2023.104714 | Mouse | Skeletal muscle Liver |
| Fletcher 2023 Transl Res | 2023 | Fletcher E, Miserlis D, Sorokolet K, Wilburn D, Bradley C, Papoutsi E, Wilkinson T, Ring A, Ferrer L, Haynatzki G, Smith RS, Bohannon WT, Koutakis P (2023) Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease. https://doi.org/10.1016/j.trsl.2023.05.002 | Mouse | Skeletal muscle |
| Wang 2023 Nature | 2023 | Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, Paré G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, Jørgensen SB, Steinberg GR (2023) GDF15 promotes weight loss by enhancing energy expenditure in muscle. https://doi.org/10.1038/s41586-023-06249-4 | Mouse | Skeletal muscle |
| Som 2023 Am J Physiol Cell Physiol | 2023 | Som R, Fink BD, Yu L, Sivitz WI (2023) Oxaloacetate regulates complex II respiration in brown fat: dependence on UCP1 expression. Am J Physiol Cell Physiol 324:C1236-48. doi: 10.1152/ajpcell.00565.2022 | Mouse | Fat |
| Shirakawa 2023 Sci Rep | 2023 | Shirakawa R, Nakajima T, Yoshimura A, Kawahara Y, Orito C, Yamane M, Handa H, Takada S, Furihata T, Fukushima A, Ishimori N, Nakagawa M, Yokota I, Sabe H, Hashino S, Kinugawa S, Yokota T (2023) Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults. Sci Rep 13:5203. https://doi.org/10.1038/s41598-023-32549-w | Human | Blood cells |
| Kyriazis 2023 Res Sq | 2023 | Kyriazis G, Serrano J, Boyd J, Mason C, Smith K, Karolyi K, Kondo S, Brown I, Maurya S, Meshram N, Serna V, Gilger J, Branch D, Gardell S, Baskin K, Ayala J, Pratley R, Goodpaster B, Coen P (2023) The TAS1R2 sweet taste receptor regulates skeletal muscle mass and fitness. https://doi.org/10.21203/rs.3.rs-2475555/v1 | Mouse | Skeletal muscle |
| Dreher 2023 Int J Obes (Lond) | 2023 | Dreher SI, Irmler M, Pivovarova-Ramich O, Kessler K, Jürchott K, Sticht C, Fritsche L, Schneeweiss P, Machann J, Pfeiffer AFH, Hrabě de Angelis M, Beckers J, Birkenfeld AL, Peter A, Niess AM, Weigert C, Moller A (2023) Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention. https://doi.org/10.1038/s41366-023-01271-y | Human | Skeletal muscle Fat |
| Cojocaru 2023 Antioxidants (Basel) | 2023 | Cojocaru KA, Luchian I, Goriuc A, Antoci LM, Ciobanu CG, Popescu R, Vlad CE, Blaj M, Foia LG (2023) Mitochondrial dysfunction, oxidative stress, and therapeutic strategies in diabetes, obesity, and cardiovascular disease. Antioxidants (Basel) 12:658. https://doi.org/10.3390/antiox12030658 | ||
| Jiang 2023 Sci Rep | 2023 | Jiang N, Wang Z, Guo X, Peng Z, He Y, Wang Q, Wu H, Cui Y (2023) Hepatic Runx1t1 improves body fat index after endurance exercise in obese mice. https://doi.org/10.1038/s41598-023-46302-w | Mouse | Liver |
| Molina 2023 JAMA Cardiol | 2023 | Molina AJA, Gnaiger E, Kitzman DW (2023) Mitochondrial respiration and exercise performance in patients with heart failure with preserved ejection fraction-reply. JAMA Cardiol 8:1101-2. https://doi.org/10.1001/jamacardio.2023.3577 | Human | Skeletal muscle |
| Harmsen 2023 J Physiol | 2023 | Harmsen JF, Kotte M, Habets I, Bosschee F, Frenken K, Jorgensen JA, de Kam S, Moonen-Kornips E, Cissen J, Doligkeit D, van de Weijer T, Erazo-Tapia E, Buitinga M, Hoeks J, Schrauwen P (2023) Exercise training modifies skeletal muscle clock gene expression but not 24-hour rhythmicity in substrate metabolism of men with insulin resistance. https://doi.org/10.1113/jp285523 | Human | Skeletal muscle |
| San-Millan 2023 Antioxidants (Basel) | 2023 | San-Millán I (2023) The key role of mitochondrial function in health and disease. Antioxidants (Basel) 12:782. https://doi.org/10.3390/antiox12040782 | Human | |
| Gonzalez-Fernandez 2023 BMC Pediatr | 2023 | González-Fernández FT, Delgado-García G, Coll JS, Silva AF, Nobari H, Clemente FM (2023) Relationship between cognitive functioning and physical fitness in regard to age and sex. . BMC Pediatr 23:204. https://doi.org/10.1186/s12887-023-04028-8 | Human | |
| Zhu 2022 Metabolism | 2022 | Zhu JY, Chen M, Mu WJ, Luo HY, Guo L (2022) Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice. https://doi.org/10.1016/j.metabol.2022.155241 | Mouse | Liver |
| Guo 2022 Sci Adv | 2022 | Guo Q, Xu Z, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z (2022) Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. https://doi.org/10.1126/sciadv.abo0340 | Mouse | Skeletal muscle Fat |
| Thapa 2022 Physiol Rep | 2022 | Thapa D, Bugga P, Mushala BAS, Manning JR, Stoner MW, McMahon B, Zeng X, Cantrell PS, Yates N, Xie B, Edmunds LR, Jurczak MJ, Scott I (2022) GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation. https://doi.org/10.14814/phy2.15415 | Mouse | Heart |
| Pileggi 2022 EBioMedicine | 2022 | Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SAL, Doucet É, Haman F, Cuperlovic-Culf M, McPherson R, Dent RRM, Harper ME (2022) Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity. https://doi.org/10.1016/j.ebiom.2022.104192 | Human | Skeletal muscle |
| Gancheva 2022 Diabetes Care | 2022 | Gancheva S, Kahl S, Pesta D, Mastrototaro L, Dewidar B, Strassburger K, Sabah E, Esposito I, Weiß J, Sarabhai T, Wolkersdorfer M, Fleming T, Nawroth P, Zimmermann M, Reichert AS, Schlensak M, Roden M (2022) Impaired hepatic mitochondrial capacity in nonalcoholic steatohepatitis associated with type 2 diabetes. https://doi.org/10.2337/dc21-1758 | Liver | |
| Gonzalez-Franquesa 2022 Redox Biol | 2022 | Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM (2022) Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. https://doi.org/10.1016/j.redox.2022.102353 | Mouse | Skeletal muscle Nervous system Liver Fat |
| Kullmann 2022 JCI Insight | 2022 | Kullmann S, Goj T, Veit R, Fritsche L, Wagner L, Schneeweiss P, Hoene M, Hoffmann C, Machann J, Niess A, Preissl H, Birkenfeld AL, Peter A, Häring HU, Fritsche A, Moller A, Weigert C, Heni M (2022) Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese. https://doi.org/10.1172/jci.insight.161498 | ||
| Neu 2022 BMJ Open | 2022 | Neu C, Skitek K, Kissler H, Baumbach P, Settmacher U, Esper Treml R, Coldewey SM (2022) Body composition, mitochondrial oxygen metabolism and metabolome of patients with obesity before and after bariatric surgery (COMMITMENT): protocol for a monocentric prospective cohort study. https://doi.org/10.1136/bmjopen-2022-062592 | Human | Skeletal muscle |
| Pedersen 2022 Nat Commun | 2022 | Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F (2022) Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. Nat Commun 13:2931. https://doi.org/10.1038/s41467-022-30629-5 | Human | Liver Fat |
| Ma 2022 Int J Obes (Lond) | 2022 | Ma H, He C, Li L, Gao P, Lu Z, Hu Y, Wang L, Zhao Y, Cao T, Cui Y, Zheng H, Yang G, Yan Z, Liu D, Zhu Z (2022) TRPC5 deletion in the central amygdala antagonizes high-fat diet-induced obesity by increasing sympathetic innervation. https://doi.org/10.1038/s41366-022-01151-x | Mouse | Fat |
| Beaulant 2022 J Hepatol | 2022 | Beaulant A, Dia M, Pillot B, Chauvin MA, Ji-Cao J, Durand C, Bendridi N, Chanon S, Vieille-Marchiset A, Da Silva CC, Patouraux S, Anty R, Iannelli A, Tran A, Gual P, Vidal H, Gomez L, Paillard M, Rieusset J (2022) Endoplasmic reticulum-mitochondria miscommunication is an early and causal trigger of hepatic insulin resistance and steatosis. https://doi.org/10.1016/j.jhep.2022.03.017 | Mouse | Liver |
| Copperi 2022 Commun Biol | 2022 | Copperi F, Schleis I, Roumain M, Muccioli GG, Casola S, Klingenspor M, Pfeifer A, Gnad T (2022) EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. https://doi.org/10.1038/s42003-022-03201-6 | Mouse | Fat |
| Napso 2022 Acta Physiol (Oxf) | 2022 | Napso T, Lean SC, Lu M, Mort EJ, Desforges M, Moghimi A, Bartels B, El-Bacha T, Fowden AL, Camm EJ, Sferruzzi-Perri AN (2022) Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice. https://doi.org/10.1111/apha.13795 | Mouse | Genital |
| De Jong 2022 Nutrients | 2022 | De Jong NP, Rudolph MC, Jackman MR, Sharp RR, Jones K, Houck J, Pan Z, Reusch JEB, MacLean PS, Bessesen DH, Bergouignan A (2022) Short-term adaptations in skeletal muscle mitochondrial oxidative capacity and metabolic pathways to breaking up sedentary behaviors in overweight or obese adults. https://doi.org/10.3390/nu14030454 | Human | Skeletal muscle |
| Legaki 2022 Curr Obes Rep | 2022 | Legaki AI, Moustakas II, Sikorska M, Papadopoulos G, Velliou RI, Chatzigeorgiou A (2022) Hepatocyte mitochondrial dynamics and bioenergetics in obesity-related non-alcoholic fatty liver disease. Curr Obes Rep 11:126-143. doi: 10.1007/s13679-022-00473-1 | Human | Liver |
| Yuan 2022 Oxid Med Cell Longev | 2022 | Yuan Q, Zeng ZL, Yang S, Li A, Zu X, Liu J (2022) Mitochondrial stress in metabolic inflammation: modest benefits and full losses. Oxid Med Cell Longev 2022:8803404. https://doi.org/10.1155/2022/8803404 | ||
| Leibold 2022 PLoS One | 2022 | Leibold S, Bagivalu Lakshminarasimha A, Gremse F, Hammerschmidt M, Michel M (2022) Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish. https://doi.org/10.1371/journal.pone.0267933 | Zebrafish Fishes | |
| Moon 2021 J Lipid Res | 2021 | Moon SH, Dilthey BG, Liu X, Guan S, Sims HF, Gross RW (2021) High-Fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress. J Lipid Res 62:100052. | Mouse | Liver |
| Fink 2021 Pharmacol Res Perspect | 2021 | Fink BD, Yu L, Coppey L, Obrosov A, Shevalye H, Kerns RJ, Yorek MA, Sivitz WI (2021) Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Pharmacol Res Perspect 9:e00701. | Rat | Liver |
| Cormier 2021 Insect Biochem Mol Biol | 2021 | Cormier RJ, Strang R, Menail H, Touaibia M, Pichaud N (2021) Systemic and mitochondrial effects of metabolic inflexibility induced by high fat diet in Drosophila melanogaster. Insect Biochem Mol Biol 133:103556. | Drosophila | |
| Baldini 2021 Life Sci | 2021 | Baldini F, Fabbri R, Eberhagen C, Voci A, Portincasa P, Zischka H, Vergani L (2021) Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity. Life Sci 265:118812. | Mouse | Fibroblast |
| Wiebe 2021 JAMA Netw Open | 2021 | Wiebe N, Ye F, Crumley ET, Bello A, Stenvinkel P, Tonelli M (2021) Temporal associations among body mass index, fasting insulin, and systemic inflammation. A systematic review and meta-analysis. JAMA Netw Open 4:e211263. doi:10.1001/jamanetworkopen.2021.1263. | ||
| Lefranc 2021 Int J Mol Sci | 2021 | Lefranc C, Friederich-Persson M, Foufelle F, Nguyen Dinh Cat A, Jaisser F (2021) Adipocyte-mineralocorticoid receptor alters mitochondrial quality control leading to mitochondrial dysfunction and senescence of visceral adipose tissue. Int J Mol Sci 22:2881. | Mouse | Fat |
| Mendham 2021 Diabetologia | 2021 | Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, Fortuin-de Smidt MC, Chibalin AV, Olsson T, Chorell E (2021) Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia 64:1642-59. | Human | Skeletal muscle |
| Axelrod 2021 EMBO Mol Med | 2021 | Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088. | Mouse | Skeletal muscle |
| Honecker 2021 Int J Obes (Lond) | 2021 | Honecker J, Weidlich D, Heisz S, Lindgren CM, Karampinos DC, Claussnitzer M, Hauner H (2021) A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function. Int J Obes (Lond) [Ephub ahead of print]. | Human | Fat |
| Watt 2021 Nat Commun | 2021 | Watt KI, Henstridge DC, Ziemann M, Sim CB, Montgomery MK, Samocha-Bonet D, Parker BL, Dodd GT, Bond ST, Salmi TM, Lee RS, Thomson RE, Hagg A, Davey JR, Qian H, Koopman R, El-Osta A, Greenfield JR, Watt MJ, Febbraio MA, Drew BG, Cox AG, Porrello ER, Harvey KF, Gregorevic P (2021) Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nat Commun 12:2887. | Mouse | Skeletal muscle |
| MacCannell 2021 Int J Obes (Lond) | 2021 | MacCannell ADV, Futers TS, Whitehead A, Moran A, Witte KK, Roberts LD (2021) Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity. Int J Obes (Lond) 45:1773-81. | Mouse | Fat |
| Remie 2021 Diabetologia | 2021 | Remie CME, Janssens GE, Bilet L, van Weeghel M, Duvivier BMFM, de Wit VHW, Connell NJ, Jörgensen JA, Schomakers BV, Schrauwen-Hinderling VB, Hoeks J, Hesselink MKC, Phielix E, Houtkooper RH, Schrauwen P (2021) Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women. Diabetologia 64:2817-28. | Human | Skeletal muscle |
| Kladnicka 2021 Biomolecules | 2021 | Kladnicka I, Cedikova M, Jedlicka J, Kohoutova M, Muller L, Plavinova I, Kripnerova M, Bludovska M, Kuncova J, Mullerova D (2021) Chronic DDE exposure modifies mitochondrial respiration during differentiation of human adipose-derived mesenchymal stem cells into mature adipocytes. Biomolecules 11:1068. | Human | Fat |
| Flensted-Jensen 2021 Free Radic Biol Med | 2021 | Flensted-Jensen M, Gram M, Dela F, Helge JW, Larsen S (2021) Six weeks of high intensity cycle training reduces H2O2 emission and increases antioxidant protein levels in obese adults with risk factors for type 2 diabetes. Free Radic Biol Med 173:1-6. | Human | Skeletal muscle |
| Yoshino 2021 Science | 2021 | Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S (2021) Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science 372:1224-29. https://doi.org/10.1126/science.abe9985 | Human | Skeletal muscle |
| Stankova 2021 Int J Mol Sci | 2021 | Staňková P, Kučera O, Peterová E, Elkalaf M, Rychtrmoc D, Melek J, Podhola M, Zubáňová V, Červinková Z (2021) Western diet decreases the liver mitochondrial oxidative flux of succinate: insight from a murine NAFLD model. https://doi.org/10.3390/ijms22136908 | Mouse | Liver |
| Song 2020 Life Sci | 2020 | Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. Life Sci 252:117633. | Mouse | Liver |
| Brunetta 2020 J Physiol | 2020 | Brunetta HS, Politis-Barber V, Petrick HL, Dennis KMJH, Kirsh AJ, Barbeau PA, Nunes EA, Holloway GP (2020) Nitrate attenuates HFD-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission. J Physiol 598:3357-71. | Mouse | Fat |
| Matsuo 2020 Am J Physiol Endocrinol Metab | 2020 | Matsuo FS, Araújo PHC, Mota RF, Carvalho AJR, Queiroz MS, Almeida BB, Ferreira KCOS, Metzner RJM, Ferrari GD, Alberici LC, Osako MK (2020) RANKL induces beige adipocyte differentiation in preadipocytes. Am J Physiol Endocrinol Metab 318:E866-77. | Mouse | Fat |
| Remie 2020 Am J Clin Nutr | 2020 | Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020) Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr 112:413-26. | Human | Skeletal muscle |
| Chen 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis 1866:165805. | Mouse | Skeletal muscle |
| Stefan 2020 Nat Rev Endocrinol | 2020 | Stefan N, Birkenfeld AL, Schulze MB, Ludwig DS (2020) Obesity and impaired metabolic health in patients with COVID-19. Nat Rev Endocrinol 2020:1‐2 [published online ahead of print, 2020 Apr 23]. | Human | |
| Qingxian 2020 Lancet | 2020 | Qingxian Cai, Chen Fengjuan, Fang Luo, Xiaohui Liu, Tao Wang, Qikai Wu, Qing He, Zhaoqin Wang, Yingxia Liu, Jun Chen, Lei Liu, Lin Xu (2020) Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. Lancet Preprint at SSRN https://doi.org/10.2139/ssrn.3556658. | Human | |
| Bhatraju 2020 N Engl J Med | 2020 | Bhatraju Pavan K, Ghassemieh Bijan J, Nichols Michelle, Kim Richard, Jerome Keith R, Nalla Arun K, Greninger Alexander L, Pipavath Sudhakar, Wurfel Mark M, Evans Laura, Kritek Patricia A, West T Eoin, Luks Andrew, Gerbino Anthony, Dale Chris R, Goldman Jason D, O’Mahony Shane, Mikacenic Carmen (2020) Covid-19 in critically ill patients in the Seattle region - case series. N Engl J Med 2020;NEJMoa2004500 [published online ahead of print, 2020 Mar 30]. | Human | |
| Petrilli 2020 medRxiv | 2020 | Petrilli Christopher M, Jones Simon A, Yang Jie, Rajagopalan Harish, O'Donnell Luke F, Chernyak Yelena, Tobin Katie, Cerfolio Robert J, Francois Fritz, Horwitz Leora I (2020) Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. medRxiv doi: https://doi.org/10.1101/2020.04.08.20057794 . | Human | |
| Cox 2020 JAMA Netw Open | 2020 | Cox Bianca, Luyten Leen J, Dockx Yinthe, Provost Eline, Madhloum Narjes, De Boever Patrick, Neven Kristof Y, Sassi Franco, Sleurs Hanne, Vrijens Karen, Vineis Paolo, Plusquin Michelle, Nawrot Tim S (2020) Association between maternal prepregnancy body mass index and anthropometric parameters, blood pressure, and retinal microvasculature in children age 4 to 6 years. JAMA Netw Open 3:e204662 | Human | |
| Alexopoulos 2020 Nat Commun | 2020 | Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL (2020) Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nat Commun 11:2397. | Mouse | Skeletal muscle Liver Fat |
| Brown 2020 MitoFit Preprint Arch | 2020 | Brown RA, Sarkar A (2020) Vitamin D deficiency: a factor in COVID-19, progression, severity and mortality? – An urgent call for research. https://doi.org/10.26124/mitofit:200001 | Human | |
| Mendham 2020 Sci Rep | 2020 | Mendham Amy E, Larsen Steen, George Cindy, Adams Kevin, Hauksson Jon, Olsson Tommy, Fortuin-de Smidt Melony C, Nono Nankam Pamela A, Hakim Olah, Goff Louise M, Pheiffer Carmen, Goedecke Julia H (2020) Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. Sci Rep 10:3785. | Fat | |
| Hafstad 2020 Antioxidants (Basel) | 2020 | Hafstad AD, Hansen SS, Lund J, Santos CXC, Boardman NT, Shah AM, Aasum E (2020) NADPH oxidase 2 mediates myocardial oxygen wasting in obesity. Antioxidants (Basel) 9:E171. | Mouse | Heart |
| Wang 2020 J Mol Med (Berl) | 2020 | Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61. | Mouse | Heart |
| Khan 2020 Cureus | 2020 | Khan QU, Zaffar S, Rehan AM, Rashid RR, Ashraf H, Hafeez F (2020) Relationship of major depression with body mass index and salivary cortisol. Cureus 12:e6577. | Human | |
| Kong 2020 JAMA Netw Open | 2020 | Kong L, Nilsson IAK, Brismar K, Gissler M, Lavebratt C (2020) Associations of different types of maternal diabetes and body mass index with offspring psychiatric disorders. JAMA Netw Open 2020 Feb 5;3(2):e1920787. | Human | |
| Murthy 2020 JAMA Cardiol | 2020 | Murthy VL, Xia R, Baldridge AS, Carnethon MR, Sidney S, Bouchard C, Sarzynski MA, Lima JAC, Lewis GD, Shah SJ, Fornage M, Shah RV (2020) Polygenic risk, fitness, and obesity in the Coronary Artery Risk Development In Young Adults (CARDIA) study. JAMA Cardiol 5:40-8. doi: 10.1001/jamacardio.2019.5220 | Human | |
| Bahrami 2020 JAMA Psychiatry | 2020 | Bahrami S, Steen NE, Shadrin A, O'Connell K, Frei O, Bettella F, Wirgenes KV, Krull F, Fan CC, Dale AM, Smeland OB, Djurovic S, Andreassen OA (2020) Shared genetic loci between body mass index and major psychiatric disorders: a genome-wide association study. JAMA Psychiatry 2020 Jan 8. doi: 10.1001/jamapsychiatry.2019.4188. | Human | |
| Popkin 2020 Lancet | 2020 | Popkin BM, Corvalan C, Grummer-Strawn LM (2020) Dynamics of the double burden of malnutrition and the changing nutrition reality. Lancet 395:65-74. | Human | |
| Hwaung 2020 Obes Rev | 2020 | Hwaung P, Heo M, Kennedy S, Hong S, Thomas DM, Shepherd J, Heymsfield SB (2020) Optimum waist circumference-height indices for evaluating adult adiposity: An analytic review. Obes Rev 21(1):e12947. doi: 10.1111/obr.12947. | Human | Fat |
| Magnesa 2020 Thesis | 2020 | Magnesa B (2020) Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effect in obese subjects and bed rest effect in healthy subjects. PhD Thesis 81. | Human | Skeletal muscle |
| Floud 2019 Neurology | 2020 | Floud S, Simpson RF, Balkwill A, Brown A, Goodill A, Gallacher J, Sudlow C, Harris P, Hofman A, Parish S, Reeves GK, Green J, Peto R, Beral V (2019) Body mass index, diet, physical inactivity, and the incidence of dementia in 1 million UK women. Neurology 94:e1-e10. doi:10.1212. | Human | |
| Keppner 2020 Thesis | 2020 | Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100. | Human | Blood cells |
| Ferguson 2020 Endocrinology | 2020 | Ferguson D, Hutson I, Tycksen E, Pietka TA, Bauerle K, Harris CA (2020) Role of mineralocorticoid receptor in adipogenesis and obesity in male mice. Endocrinology 161:bqz010. https://doi.org/10.1210/endocr/bqz010 | Mouse | |
| Rocha 2020 Sci Adv | 2020 | Rocha AL, de Lima TI, de Souza GP, Corrêa RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, Dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA (2020) Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. Sci Adv 6:eabc6250. | Mouse | Fat |
| Palavicini 2020 JCI Insight | 2020 | Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286. | Mouse | Nervous system |
| Anand 2020 Toxicol In Vitro | 2020 | Anand CR, Bhavya B, Jayakumar K, Harikrishnan VS, Gopala S (2020) Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia. Toxicol In Vitro 70:105048. | Rat | Heart |
| Garcia 2020 Mol Hum Reprod | 2020 | Garcia BM, Machado TS, Carvalho KF, Nolasco P, Nociti RP, Del Collado M, Capo Bianco MJD, Grejo MP, Neto JDA, Sugiyama FHC, Tostes K, Pandey AK, Gonçalves LM, Perecin F, Meirelles FV, Ferraz JBS, Vanzela EC, Boschero AC, Guimarães FEG, Abdulkader F, Laurindo FRM, Kowaltowski AJ, Chiaratti MR (2020) Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis. Mol Hum Reprod 26:938-52. | Mouse | Liver |
| Song 2020 Obes Facts | 2020 | Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) Increased insulin sensitivity by high-altitude hypoxia in mice with high-fat diet-induced obesity is associated with activated AMPK signaling and subsequently enhanced mitochondrial biogenesis in skeletal muscles. Obes Facts 13:455-72. | Skeletal muscle | |
| Rodrigues 2020 J Appl Physiol (1985) | 2020 | Rodrigues GC, Rocha NN, Maia LA, Melo I, Simões AC, Antunes MA, Bloise FF, Woyames J, da-Silva WS, Capelozzi VL, Abela G, Ball L, Pelosi P, Rocco PRM, Silva PL (2020) Impact of experimental obesity on diaphragm structure, function and bioenergetics. J Appl Physiol (1985) 129:1062-74. | Rat | Skeletal muscle |
| Agil 2020 J Clin Med | 2020 | Agil A, Chayah M, Visiedo L, Navarro-Alarcon M, Rodríguez Ferrer JM, Tassi M, Reiter RJ, Fernández-Vázquez G (2020) Melatonin improves mitochondrial dynamics and function in the kidney of Zücker diabetic fatty rats. J Clin Med 9:E2916. | Rat | Kidney |
| Hoffmann 2020 J Clin Endocrinol Metab | 2020 | Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571. | Human | Skeletal muscle Fat |
| Lantier 2020 Diabetes | 2020 | Lantier Louise, Williams Ashley S, Williams Ian M, Guerin Amanda, Bracy Deanna P, Goelzer Mickael, Foretz Marc, Viollet Benoit, Hughey Curtis C, Wasserman David H (2020) Reciprocity between skeletal muscle AMPK deletion and insulin action in diet-induced obese mice. Diabetes 69:1636-49. | Mouse | Skeletal muscle |
| Abu Bakar 2020 Eur J Pharmacol | 2020 | Abu Bakar MH, Shariff KA, Tan JS, Lee LK (2020) Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways. Eur J Pharmacol 883:173371. | Rat | Skeletal muscle |
| Vaccari 2020 Eur J Appl Physiol | 2020 | Vaccari F, Passaro A, D'Amuri A, Sanz JM, Di Vece F, Capatti E, Magnesa B, Comelli M, Mavelli I, Grassi B, Fiori F, Bravo G, Avancini A, Parpinel M, Lazzer S (2020) Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur J Appl Physiol 120:1787-803. | Human | Skeletal muscle |
| Kapser-Fischer 2020 Thesis | 2020 | Kapser-Fischer IP (2020) Dietary interventions in C57BL/6 mice and their interplay with selected metabolic and genetic parameters. PhD Thesis 120. | Mouse | Fat |
| Politis-Barber 2020 Am J Physiol Endocrinol Metab | 2020 | Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87. | Mouse | Fat |
| Falcao-Tebas 2020 J Physiol | 2020 | Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol 598:4251-70. | Rat | Skeletal muscle |
| Gnad 2020 Cell Metab | 2020 | Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A (2020) Adenosine/A2B receptor signaling ameliorates the effects of aging and counteracts obesity. Cell Metab 32:56-70.e7. | Mouse | Skeletal muscle |
| Edmunds 2020 Mol Metab | 2020 | Edmunds LR, Xie B, Mills AM, Huckestein BR, Undamatla R, Murali A, Pangburn MM, Martin J, Sipula I, Kaufman BA, Scott I, Jurczak MJ (2020) Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab 41:101051. | Mouse | Liver |
| Wefers 2020 Mol Metab | 2020 | Wefers J, Connell NJ, Fealy CE, Andriessen C, de Wit V, van Moorsel D, Moonen-Kornips E, Jörgensen JA, Hesselink MKC, Havekes B, Hoeks J, Schrauwen P (2020) Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals. Mol Metab 41:101050. | Human | Skeletal muscle |
| Weber 2020 FASEB J | 2020 | Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, Sebastián D, Soler-Vázquez MC, Montironi C, Recalde S, Fucho R, Calderón-Domínguez M, Mir JF, Bartrons R, Escola-Gil JC, Sánchez-Infantes D, Zorzano A, Llorente-Cortes V, Casals N, Valentí V, Frühbeck G, Herrero L, Serra D (2020) Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB J 34:11816-37. | Mouse | Liver |
| Boardman 2020 Am J Physiol Heart Circ Physiol | 2020 | Boardman NT, Pedersen TM, Rossvoll L, Hafstad AD, Aasum E (2020) Diet-induced obese mouse hearts tolerate an acute high fatty acid exposure that also increases ischemic tolerance. Am J Physiol Heart Circ Physiol 319:H682-93. | Mouse | Heart |
| Jansen 2019 Am J Physiol Heart Circ Physiol | 2019 | Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS (2019) Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol 317:H290-H299. | Mouse | Heart |
| Penniman 2019 Mol Metab | 2019 | Penniman CM, Suarez Beltran PA, Bhardwaj G, Junck TL, Jena J, Poro K, Hirshman MF, Goodyear LJ, O'Neill BT (2019) Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity. Mol Metab 30:203-220. | Mouse | Skeletal muscle |
| Chroeis 2019 Basic Clin Pharmacol Toxicol | 2019 | Chroeis KM, Larsen S, Pedersen JS, Rygg MO, Boilsen AEB, Bendtsen F, Dela F (2019) Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue. https://doi.org/10.1111/bcpt.13304 | Human | Liver |
| Lefranc 2019 Hypertension | 2019 | Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A (2019) MR (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity. Hypertension 73:458-68. | Mouse | Fat |
| Rigotto 2019 Oxid Med Cell Longev | 2019 | Rigotto G, Basso E (2019) Mitochondrial dysfunctions: a thread sewing together Alzheimer's disease, diabetes, and obesity. Oxid Med Cell Longev 2019:7210892. doi: 10.1155/2019/7210892. | Human | Nervous system Fat |
| Brunetta 2019 J Funct Foods | 2019 | Brunetta HS, de Paula GC, Fritzen M, Cecchini MS, dos Santos GJ, Nazari EM, Rafacho A, de Bem AF, Nunes EA (2019) Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. J Funct Foods 62:103544. | Mouse | Skeletal muscle |
| Miranda-Silva 2019 Acta Physiologica | 2019 | Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378. | Rat | Heart |
| McMurray 2019 FASEB J | 2019 | McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME (2019) Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J 33:13515-26. | Mouse | Skeletal muscle |
| Gancheva 2019 Nat Commun | 2019 | Gancheva S, Ouni M, Jelenik T, Koliaki C, Szendroedi J, Toledo FGS, Markgraf DF, Pesta DH, Mastrototaro L, De Filippo E, Herder C, Jähnert M, Weiss J, Strassburger K, Schlensak M, Schürmann A, Roden M (2019) Dynamic changes of muscle insulin sensitivity after metabolic surgery. Nat Commun 10:4179. | Human | Skeletal muscle |
| Kakimoto 2019 PLoS One | 2019 | Kakimoto PA, Chausse B, Caldeira da Silva CC, Donato Júnior J, Kowaltowski AJ (2019) Resilient hepatic mitochondrial function and lack of iNOS dependence in diet-induced insulin resistance. PLoS One 14:e0211733. | Mouse | Liver |
| Pedrotti 2019 Sci Adv | 2019 | Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472. | Mouse | Fat |
| Oliveira 2019 Mol Nutr Food Res | 2019 | Oliveira TE, Castro É, Belchior T, Andrade ML, Chaves-Filho AB, Peixoto AS, Moreno MF, Ortiz Silva M, Moreira RJ, Inague A, Yoshinaga MY, Miyamoto S, Moustaid-Moussa N, Festuccia WT (2019) Fish oil protects wild type and uncoupling protein 1 deficient mice from obesity and glucose intolerance by increasing energy expenditure. Mol Nutr Food Res 63:e1800813. | Mouse | Fat |
| Wessels 2019 Obesity (Silver Spring) | 2019 | Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T (2019) Adipose mitochondrial respiratory capacity in obesity is impaired independently of glycemic status of tissue donors. Obesity (Silver Spring) 27:756-66. | Human | Fat |
| Gregg 2019 J Biol Chem | 2019 | Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at Complex I in pancreatic β-cells. J Biol Chem 294:4656-66. | Mouse | Islet cell;pancreas;thymus |
| Ferey 2019 Am J Physiol Heart Circ Physiol | 2019 | Ferey J, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH (2019) Maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independent of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol 316:H1202-H1210. | Mouse | Heart |
| Gonzalez-Mariscal 2019 FASEB J | 2019 | González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63. | Mouse | Skeletal muscle |
| Glombik 2019 Neurotox Res | 2019 | Głombik K, Detka J, Góralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24. | Rat | Nervous system |
| Heinonen 2019 Obes Rev | 2019 | Heinonen S, Jokinen R, Rissanen A, Pietiläinen KH (2019) White adipose tissue mitochondrial metabolism in health and in obesity. Obes Rev 21:e12958. | Fat | |
| Ejarque 2019 Int J Obes (Lond) | 2019 | Ejarque M, Ceperuelo-Mallafré V, Serena C, Maymo-Masip E, Duran X, Díaz-Ramos A, Millan-Scheiding M, Núñez-Álvarez Y, Núñez-Roa C, Gama P, Garcia-Roves PM, Peinado MA, Gimble JM, Zorzano A, Vendrell J, Fernández-Veledo S (2019) Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells. Int J Obes (Lond) 43:1256-68. | Human | Fat |
| Hood 2019 Nutr Diabetes | 2019 | Hood K, Ashcraft J, Watts K, Hong S, Choi W, Heymsfield SB, Gautam RK, Thomas D (2019) Allometric scaling of weight to height and resulting body mass index thresholds in two Asian populations. Nutr Diabetes 9:2. doi: 10.1038/s41387-018-0068-3. | Human | |
| Weir 2019 StatPearls | 2019 | Weir CB, Jan A (2019) BMI classification percentile and cut off points. StatPearls 2019 Dec 7. | Human | |
| Misra 2019 J Postgrad Med | 2019 | Misra P, Singh AK, Archana S, Lohiya A, Kant S (2019) Relationship between body mass index and percentage of body fat, estimated by bio-electrical impedance among adult females in a rural community of North India: A cross-sectional study. J Postgrad Med 65:134-40. | Human | Fat |
| Bittel 2019 Diabetologia | 2019 | Bittel AJ, Bittel DC, Mittendorfer B, Patterson BW, Okunade AL, Yoshino J, Porter LC, Abumrad NA, Reeds DN, Cade WT (2019) A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes. Diabetologia 63:611-23. | Human | Skeletal muscle |
| NCD-RisC 2019 Nature | 2019 | NCD Risk Factor Collaboration (NCD-RisC)(2019) Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature 569:260-4. | Human | |
| De Onis 2019 Public Health Nutrition | 2019 | de Onis M, Borghi E, Arimond M, Webb P, Croft T, Saha K, De-Regil LM, Thuita F, Heidkamp R, Krasevec J, Hayashi C, Flores-Ayala R (2019) Prevalence thresholds for wasting, overweight and stunting in children under 5 years. Public Health Nutrition 22:175-9. | Human | |
| Fumagalli 2019 JAMA Cardiol | 2019 | Fumagalli C, Maurizi N, Day SM, Ashley EA, Michels M, Colan SD, Jacoby D, Marchionni N, Vincent-Tompkins J, Ho CY, Olivotto I, SHARE Investigators (2019) Association of obesity with adverse long-term outcomes in hypertrophic cardiomyopathy. JAMA Cardiol 2019 Nov 6:1-8. doi: 10.1001/jamacardio.2019.4268. | Human | |
| Poudel 2019 Can J Physiol Pharmacol | 2019 | Poudel A, Zhou JY, Mekala N, Welchko R, Rosca MG, Li L (2019) Berberine hydrochloride protects against cytokine-induced inflammation through multiple pathways in undifferentiated C2C12 myoblast cells. Can J Physiol Pharmacol 97:699-707. | Mouse | Skeletal muscle |
| Yang 2019 JAMA Netw Open | 2019 | Yang J, Christophi CA, Farioli A, Baur DM, Moffatt S, Zollinger TW, Kales SN (2019) Association between push-up exercise capacity and future cardiovascular events among active adult men. JAMA Netw Open 2019;2:e188341. | Human | |
| Kenny 2019 Circ Res | 2019 | Kenny HC, Abel ED (2019) Heart failure in Type 2 Diabetes Mellitus. Circ Res 124:121–41. | Human | Heart |
| Dai 2019 Front Endocrinol (Lausanne) | 2019 | Dai W, Jiang L (2019) Dysregulated mitochondrial dynamics and metabolism in obesity, diabetes, and cancer. Front Endocrinol (Lausanne) 10:570. | ||
| Winnica 2019 Antioxid Redox Signal | 2019 | Winnica D, Corey C, Mullett S, Reynolds M, Hill G, Wendell S, Que L, Holguin F, Shiva S (2019) Bioenergetic differences in the airway epithelium of lean versus obese asthmatics are driven by nitric oxide and reflected in circulating platelets. Antioxid Redox Signal 31:673–86. | Human | Lung;gill Endothelial;epithelial;mesothelial cell Blood cells Platelet |
| Ahmed 2019 Mol Nutr Food Res | 2019 | Ahmed N, Tcheng M, Roma A, Buraczynski M, Jayanth P, Rea K, Akhtar TA, Spagnuolo PA (2019) Avocatin B protects against lipotoxicity and improves insulin sensitivity in diet-induced obesity. Mol Nutr Food Res 63:e1900688. | Mouse Rat | Skeletal muscle Islet cell;pancreas;thymus |
| Chen 2018 Endocrinology | 2018 | Chen Y, McCommis KS, Ferguson D, Hall AM, Harris CA, Finck BN (2018) Inhibition of the mitochondrial pyruvate carrier by tolylfluanid. Endocrinology 159:609-21. | Mouse | Fat |
| Brunetta 2018 Exp Physiol | 2018 | Brunetta HS, de Paula GC, de Oliveira J, Martins EL, Dos Santos GJ, Filho AG, Rafacho A, de Bem AF, Nunes EA (2018) Decrement in resting and insulin-stimulated soleus muscle mitochondrial respiration is an early event in diet-induced obesity in mice. Exp Physiol 104:306-21. | Mouse | Skeletal muscle |
| Lund 2018 Acta Physiol (Oxf) | 2018 | Lund MT, Larsen S, Hansen M, Courraud J, Floyd AK, Støckel M, Helge JW, Dela F (2018) Mitochondrial respiratory capacity remains stable despite a comprehensive and sustained increase in insulin sensitivity in obese patients undergoing gastric bypass surgery. Acta Physiol (Oxf) 223:e13032. | Human | Skeletal muscle |
| D'Souza 2018 J Lipid Res | 2018 | D'Souza K, Nzirorera C, Cowie AM, Varghese GP, Trivedi P, Eichmann TO, Biswas D, Touaibia M, Morris AJ, Aidinis V, Kane DA, Pulinilkunnil T, Kienesberger PC (2018) Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism. J Lipid Res 59:1805-17. | Mouse | Skeletal muscle |
| Apostolopoulou 2018 Thesis | 2018 | Apostolopoulou M (2018) Determinants of insulin sensitivity in obesity and recent-onset type 2 diabetes mellitus. PhD Thesis 77. | Human | Liver |
| Bhaskaran 2018 EMBO Rep | 2018 | Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS (2018) Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. EMBO Rep 19. pii: e45009. | Mouse | Fat |
| Vercesi 2018 Free Radic Biol Med | 2018 | Vercesi AE, Castilho RF, Kowaltowski AJ, Oliveira HC, de Souza-Pinto NC, Figueira TR, Busanello E (2018) Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition. Free Radic Biol Med 129:1–24. | ||
| Madeo 2018 Science | 2018 | Madeo F, Eisenberg T, Pietrocola F, Kroemer G (2018) Spermidine in health and disease. Science 359:eaan2788. | Human | |
| Thrush 2018 Int J Obes (Lond) | 2018 | Thrush AB, Antoun G, Nikpay M, Patten DA, DeVlugt C, Mauger JF, Beauchamp BL, Lau P, Reshke R, Doucet É, Imbeault P, Boushel R, Gibbings D, Hager J, Valsesia A, Slack R, Al-Dirbashi OY, Dent R, McPherson R, Harper ME (2018) Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism. Int J Obes (Lond) 42:353-62. | Human | Skeletal muscle |
| Fouret 2018 Br J Nutr | 2018 | Fouret G, Gaillet S, Lecomte J, Bonafos B, Djohan F, Barea B, Badia E, Coudray C, Feillet-Coudray C (2018) 20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat-high-fructose diet. Br J Nutr 119:368-80. | Rat | Liver |
| Monaco 2018 Diabetologia | 2018 | Monaco CMF, Proudfoot R, Miotto PM, Herbst EAF, MacPherson REK, Holloway GP (2018) α-linolenic acid supplementation prevents exercise-induced improvements in white adipose tissue mitochondrial bioenergetics and whole-body glucose homeostasis in obese Zucker rats. Diabetologia 61:433-44. | Rat | Skeletal muscle Fat |
| Gutierrez-Sacristan 2018 Bioinformatics | 2018 | Gutiérrez-Sacristán A, Bravo À, Giannoula A, Mayer MA, Sanz F, Furlong LI (2018) comoRbidity: an R package for the systematic analysis of disease comorbidities. Bioinformatics 34:3228–3230. | Human | |
| Gutin 2018 Soc Theory Health | 2018 | Gutin I (2018) In BMI we trust: reframing the body mass index as a measure of health. Soc Theory Health 16:256–71. | Human | |
| Pearson-Stuttard 2018 Lancet Diabetes Endocrinol | 2018 | Pearson-Stuttard J, Zhou B, Kontis V, Bentham J, Gunter MJ, Ezzati M (2018) Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment. Lancet Diabetes Endocrinol 6:e6-e15. | Human | |
| Mialich 2018 J Electr Bioimp | 2018 | Mialich MS, Silva BR, Jordao AA (2018) Cutoff points of BMI for classification of nutritional status using bioelectrical impedance analysis. J Electr Bioimp 9:24-30. | Human | Fat |
| Cerqueira 2018 Adv Nutr | 2018 | Cerqueira MS, Santos CAD, Silva DAS, Amorim PRDS, Marins JCB, Franceschini SDCC (2018) Validity of the body adiposity index in predicting body fat in adults: a systematic review. Adv Nutr 9:617-24. | Human | Fat |
| Woolcott 2018 Sci Rep | 2018 | Woolcott OO, Bergman RN (2018) Relative fat mass (RFM) as a new estimator of whole-body fat percentage ─ A cross-sectional study in American adult individuals. Sci Rep 8:10980. | Human | Fat |
| Mui 2018 Am J Mens Health | 2018 | Mui P, Hill SE, Thorpe RJ Jr (2018) Overweight and obesity differences across ethnically diverse subgroups of asian american men. Am J Mens Health 12:1958-65. | Human | |
| Davis 2018 FASEB J | 2018 | Davis RAH, Deemer SE, Bergeron JM, Little JT, Warren JL, Fisher G, Smith DL Jr, Fontaine KR, Dickinson SL, Allison DB, Plaisance EP (2018) Dietary R, S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet. FASEB J 33:2409-21. | Mouse | Skeletal muscle |
| Cree-Green 2018 Diabetes | 2018 | Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, Mcclatchey PM, Bauer TA, Regensteiner JG, Reusch JEB (2018) Supplemental oxygen improves in-vivo mitochondrial oxidative phosphorylation flux in sedentary obese adults with type 2 diabetes. Diabetes 67:1369-79. | Human | Skeletal muscle |
| Bytautiene 2018 J Dev Orig Health Dis | 2018 | Bytautiene Prewit E, Porter C, La Rosa M, Bhattarai N, Yin H, Gamble P, Kechichian T, Sidossis LS (2018) Adipose tissue uncoupling protein 1 levels and function are increased in a mouse model of developmental obesity induced by maternal exposure to high-fat diet. J Dev Orig Health Dis 9:401-8. | Mouse | Fat |
| Bricambert 2018 Nat Commun | 2018 | Bricambert J, Alves-Guerra MC, Esteves P, Prip-Buus C, Bertrand-Michel J, Guillou H, Chang CJ, Vander Wal MN, Canonne-Hergaux F, Mathurin P, Raverdy V, Pattou F, Girard J, Postic C, Dentin R (2018) The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. Nat Commun 9:2092. | Mouse | Liver |
| Mills 2018 Nature 560 | 2018 | Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET (2018) Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature 560:102-6. https://doi.org/10.1038/s41586-018-0353-2 | Mouse | Fat |
| De Mello 2018 Life Sci | 2018 | de Mello AH, Costa AB, Engel JDG, Rezin GT (2018) Mitochondrial dysfunction in obesity. Life Sci 192:26-32. doi: 10.1016/j.lfs.2017.11.019 | ||
| Collins 2018 Front Physiol | 2018 | Collins Kelsey H, Herzog Walter, MacDonald Graham Z, Reimer Raylene A, Rios Jaqueline L, Smith Ian C, Zernicke Ronald F, Hart David A (2018) Obesity, metabolic syndrome, and musculoskeletal disease: common inflammatory pathways suggest a central role for loss of muscle integrity. Front Physiol 9:112. | Human | Skeletal muscle |
| Remor 2018 Mol Neurobiol | 2018 | Remor AP, da Silva RA, de Matos FJ, Glaser V, de Paula Martins R, Ghisoni K, da Luz Scheffer D, Andia DC, Portinho D, de Souza AP, de Oliveira PA, Prediger RD, Torres AI, Linhares RMM, Walz R, Ronsoni MF, Hohl A, Rafacho A, Aguiar AS Jr, De Paul AL, Latini A (2018) Chronic metabolic derangement-induced cognitive deficits and neurotoxicity are associated with REST inactivation. Mol Neurobiol 56:1539-57. | Rat | Nervous system |
| Cooper 2018 Exp Physiol | 2018 | Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE (2018) Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol 103:1206-12. | Mouse | Nervous system |
| Pardo 2018 FASEB J | 2018 | Pardo R, Vilà M, Cervela L, de Marco M, Gama-Pérez P, González-Franquesa A, Statuto L, Vilallonga R, Simó R, Garcia-Roves PM, Villena JA (2018) Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue. FASEB J 33:2343-58. | Mouse | Fat |
| Ejarque 2018 Int J Obes (Lond) | 2018 | Ejarque M, Ceperuelo-Mallafré V, Serena C, Maymo-Masip E, Duran X, Díaz-Ramos A, Millan-Scheiding M, Núñez-Álvarez Y, Núñez-Roa C, Gama P, Garcia-Roves PM, Peinado MA, Gimble JM, Zorzano A, Vendrell J, Fernández-Veledo S (2018) Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells. Int J Obes (Lond) 43:1256-68. | Human | Fat |
| Falcao-Tebas 2018 J Physiol | 2018 | Falcão-Tebas F, Kuang J, Arceri C, Kerris JP, Andrikopoulos S, Marin EC, McConell GK (2018) Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by paternal high fat diet. J Physiol 597:121-36. | Rat | Skeletal muscle |
| Wilmanns 2018 Mol Metab | 2018 | Wilmanns JC, Pandey R, Hon O, Chandran A, Schilling JM, Forte E, Wu Q, Cagnone G, Bais P, Philip V, Coleman D, Kocalis H, Archer SK, Pearson JT, Ramialison M, Heineke J, Patel HH, Rosenthal NA, Furtado MB, Costa MW (2018) Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Mol Metab 20:102-14. | Mouse | Heart |
| Real-Hohn 2018 bioRxiv | 2018 | Real-Hohn A, Navegantes C, Ramos K, Ramos-Filho D, Cahuê F, Galina A, Salerno V (2018) Hexokinase: a central player in the synergism of high-intensity intermittent exercise and every-other-day intermittent fasting regimen on energy metabolism adaptations. bioRxiv doi: https://doi.org/10.1101/389668. | Rat | Skeletal muscle |
| Wang 2018 J Nutr Biochem | 2018 | Wang Y, Fouret G, Bonafos B, Blachnio-Zabielska A, Leroy T, Crouzier D, Barea B, Gaillet S, Moro C, Lecomte J, Coudray C, Feillet-Coudray C (2018) Long-term follow-up of muscle lipid accumulation, mitochondrial activity and oxidative stress and their relationship with impaired glucose homeostasis in high fat high fructose diet-fed rats. J Nutr Biochem 64:182-97. | Rat | Skeletal muscle |
| Rudnicki 2018 Elife | 2018 | Rudnicki M, Abdifarkosh G, Nwadozi E, Ramos SV, Makki A, Sepa-Kishi DM, Ceddia RB, Perry CG, Roudier E, Haas TL (2018) Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth. Elife 7:e39780. | Mouse | Fat |
| De Lima Junior 2018 EBioMedicine | 2018 | De Lima Junior JC, Souza GF, Moura-Assis A, Gaspar RS, Gaspar JM, Rocha AL, Ferrucci DL, Lima TI, Victório SC, Bonfante ILP, Cavaglieri CR, Pareja JC, Brunetto SQ, Ramos CD, Geloneze B, Mori MA, Silveira LR, Segundo GRS, Ropelle ER, Velloso LA (2018) Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency. EBioMedicine 39:436-47. | Mouse | Fat |
| Wollner 2017 J Public Health Res | 2017 | Wollner M, Paulo Roberto BB, Alysson Roncally SC, Jurandir N, Edil LS (2017) Accuracy of the WHO's body mass index cut-off points to measure gender- and age-specific obesity in middle-aged adults living in the city of Rio de Janeiro, Brazil. J Public Health Res 6:904. | Human | Fat |
| Da Silva 2017 Nutrition | 2017 | da Silva BR, Mialich MS, de Paula FJA, Jordao AA (2017) Comparison of new adiposity indices for the prediction of body fat in hospitalized patients. Nutrition 42:99-105. | Human | Fat |
| Pollack 2017 J Gerontol A Biol Sci Med Sci | 2017 | Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, Crandall JP (2017) Resveratrol improves vascular function and mitochondrial number but not glucose metabolism in older adults. J Gerontol A Biol Sci Med Sci 72:1703–9. | Human | Skeletal muscle |
| Fink 2017 Pharmacol Res Perspect | 2017 | Fink BD, Guo DF, Kulkarni CA, Rahmouni K, Kerns RJ, Sivitz WI (2017) Metabolic effects of a mitochondrial-targeted coenzyme Q analog in high fat fed obese mice. Pharmacol Res Perspect 5:e00301. | Mouse | Liver |
| Wolff 2017 Thesis | 2017 | Wolff C (2017) Impact of lipid metabolism on skeletal muscle mitochondrial function in type 2 diabetes mellitus patients. Dissertation p68. | Horse Human | Skeletal muscle |
| Pino 2017 Int J Obes (Lond) | 2017 | Pino MF, Divoux A, Simmonds AV, Smith SR, Sparks LM (2017) Investigating the effects of Orexin-A on thermogenesis in human deep neck brown adipose tissue. Int J Obes (Lond) 41:1646-53. | Human | Fat |
| Newsom 2017 Am J Physiol Endocrinol Metab | 2017 | Newsom SA, Miller BF, Hamilton KL, Ehrlicher SE, Stierwalt HD, Robinson MM (2017) Long-term rates of mitochondrial protein synthesis are increased in mouse skeletal muscle with high fat feeding regardless of insulin sensitizing treatment. Am J Physiol Endocrinol Metab 313:552-62. | Mouse | Skeletal muscle |
| NCD-RisC 2017 Lancet | 2017 | NCD Risk Factor Collaboration (NCD-RisC) (2017) Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet 390:2627–42. | Human | |
| Westphal 2017 US Patent | 2017 | Westphal S, Fromme T, Klingenspor M (2017) Fgf-8 for use in treating diseases or disorders of energy homeostasis. US Patent US20170258874 A1. | Mouse | |
| Darrell 2017 US Patent | 2017 | Neufer PD, Anderson EJ, Szeto HH (2017) Methods for preventing or treating insulin resistance. US Patent US20170100450 A1. | Human Rat | Skeletal muscle |
| Warren 2017 J Nutr Metab | 2017 | Warren JL, Gower BA, Hunter GR, Windham ST, Moellering DR, Fisher G (2017) Associations of mitochondrial fatty acid oxidation with body fat in premenopausal women. J Nutr Metab 2017:7832057. | Human | Skeletal muscle |
| Bowen 2017 J Am Heart Assoc | 2017 | Bowen TS, Brauer D, Rolim NPL, Bækkerud FH, Kricke A, Ormbostad Berre AM, Fischer T, Linke A, da Silva GJ, Wisloff U, Adams V (2017) Exercise training reveals inflexibility of the diaphragm in an animal model of patients with obesity-driven heart failure with a preserved ejection fraction. J Am Heart Assoc 6. pii: e006416. | Rat | Skeletal muscle |
| Carraro 2017 Mol Cell Endocrinol | 2017 | Carraro RS, Souza GF, Solon C, Razolli DS, Chausse B, Barbizan R, Victorio SC, Velloso LA (2017) Hypothalamic mitochondrial abnormalities occur downstream of inflammation in diet-induced obesity. Mol Cell Endocrinol 460:238-45. | Mouse | Nervous system |
| Rouet 2017 US Patent | 2017 | Rouet P, Smih F (2017) ApoO for use in method for treating cancer and various pathophysiological situations. US Patent US20170035842 A1. | Human Mouse | Heart Liver |
| Soares 2017 Diab Vasc Dis Res | 2017 | Soares RN, Reimer RA, Doyle-Baker PK, Murias JM (2017) Metabolic inflexibility in individuals with obesity assessed by near-infrared spectroscopy. Diab Vasc Dis Res 14:502-9. | Human | |
| Pravenec 2017 Physiol Res | 2017 | Pravenec M1, Zídek V, Landa V, Mlejnek P, Šilhavý J, Šimáková M, Trnovská J, Škop V, Marková I, Malínská H, Hüttl M, Kazdová L, Bardová K, Tauchmannová K, Vrbacký M, Nůsková H, Mráček T, Kopecký J, Houštěk J (2017) Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity. Physiol Res 66:917-24. | Rat | Endothelial;epithelial;mesothelial cell Fibroblast |
| Perks 2017 Sci Adv | 2017 | Perks KL, Ferreira N, Richman TR, Ermer JA, Kuznetsova I, Shearwood AJ, Lee RG, Viola HM, Johnstone VPA, Matthews V, Hool LC, Rackham O, Filipovska A (2017) Adult-onset obesity is triggered by impaired mitochondrial gene expression. Sci Adv 3:e1700677. | Mouse | Heart Liver |
| Most 2017 Eur J Clin Nutr | 2017 | Most J, Penders J, Lucchesi M, Goossens GH, Blaak EE (2017) Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women. Eur J Clin Nutr 71:1040-5. | Human | Skeletal muscle |
| Vigueira 2017 Exp Physiol | 2017 | Vigueira PA, McCommis KS, Hodges WT, Schweitzer GG, Cole SL, Oonthonpan L, Taylor EB, McDonald WG, Kletzien RF, Colca JR, Finck BN (2017) The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol 102:985-99. | Human | Kidney HEK |
| Trewin 2017 PLOS ONE | 2017 | Trewin AJ, Levinger I, Parker L, Shaw CS, Serpiello FR, Anderson MJ, McConell GK, Hare DL, Stepto NK (2017) Acute exercise alters skeletal muscle mitochondrial respiration and H2O2 emission in response to hyperinsulinemic-euglycemic clamp in middle-aged obese men. PLOS ONE 12:e0188421. | Human | Skeletal muscle |
| Rowley 2017 Thesis | 2017 | Rowley TJ (2017) The effect of cocoa flavanols on β-cell mass and function. Master's Thesis p131. | Rat | Islet cell;pancreas;thymus |
| Goedecke 2017 JMIR Res Protoc | 2017 | Goedecke JH, Mendham AE, Clamp L, Nono Nankam PA, Fortuin-de Smidt MC, Phiri L, Micklesfield LK, Keswell D, Woudberg NJ, Lecour S, Alhamud A, Kaba M, Lutomia FM, van Jaarsveld PJ, de Villiers A, Kahn SE, Chorell E, Hauksson J, Olsson T (2017) An exercise intervention to unravel the mechanisms underlying insulin resistance in a cohort of black South African women: Protocol for a randomized controlled trial. JMIR Res Protoc 03/10/2017:9098. | Human | Skeletal muscle Fat |
| Linden 2016 Am J Physiol Gastrointest Liver Physiol | 2017 | Linden MA, Fletcher JA, Meers GM, Thyfault JP, Laughlin MH, Rector RS (2017) A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. Am J Physiol Gastrointest Liver Physiol 311:G387-95. | Rat | Liver |
| Mondal 2017 J Clin Diagn Res | 2017 | Mondal H, Mishra SP (2017) Effect of BMI, body fat percentage and fat free mass on maximal oxygen consumption in healthy young adults. J Clin Diagn Res 11:CC17-20. | Human | |
| Saben 2016 Cell Rep | 2016 | Saben JL, Boudoures AL, Asghar Z, Thompson A, Drury A, Zhang W, Chi M, Cusumano A, Scheaffer S, Moley KH (2016) Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations. Cell Rep 16:1-8. | Mouse | Skeletal muscle |
| Johnson 2016 Diabetes | 2016 | Johnson ML, Distelmaier K, Lanza IR, Irving BA, Robinson MM, Konopka AR, Shulman GI, Nair KS (2016) Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults. Diabetes 65:74-84. | Human | Skeletal muscle |
| Korre 2016 Am J Cardiol | 2016 | Korre M, Porto LG, Farioli A, Yang J, Christiani DC, Christophi CA, Lombardi DA, Kovacs RJ, Mastouri R, Abbasi S, Steigner M, Moffatt S, Smith D, Kales SN (2016) Effect of body mass index on left ventricular mass in career male firefighters. Am J Cardiol 118:1769-1773. | Human | Heart |
| Most 2016 Am J Clin Nutr | 2016 | Most J, Timmers S, Warnke I, Jocken JW, van Boekschoten M, de Groot P, Bendik I, Schrauwen P, Goossens GH, Blaak EE (2016) Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial. Am J Clin Nutr 104:215-27. | Human | Skeletal muscle |
| McCurdy 2016 JCI Insight | 2016 | McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE (2016) Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight 1:e86612. | Other mammals | Skeletal muscle |
| Lashbrook 2016 Thesis | 2016 | Lashbrook M (2016) Functional responses of cardiac and skeletal muscle mitochondria to short-term obesity: are all obesities the same? Master's Thesis 63pp. | Mouse Other mammals | Heart Skeletal muscle |
| Li 2016 Sci Rep | 2016 | Li N, Guenancia C, Rigal E, Hachet O, Chollet P, Desmoulins L, Leloup C, Rochette L, Vergely C (2016) Short-term moderate diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice. Sci Rep 6:30817 | Mouse | Heart |
| Bernardo 2015 J Nutr Biochem | 2016 | Bernardo AF, Cortez E, Neves FA, Vieira AKG, Soares V, Rodrigues-Cunha AC, Andrade DC, Thole AA, Gabriel-Costa D, Brum PC, Moura AS, Garcia-Souza EP (2015) Overnutrition during lactation leads to impairment in insulin signaling, upregulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. J Nutr Biochem 29:124-32. | Mouse | Heart |
| Bullon 2016 Periodontol 2000 | 2016 | Bullon P, Newman HN, Battino M (2016) Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a shared pathology via oxidative stress and mitochondrial dysfunction? Periodontol 2000 64:139-53. | ||
| Fink 2016 Am J Physiol Regul Integr Comp Physiol | 2016 | Fink BD, Bai F, Yu L, Sivitz WI (2016) Impaired utilization of membrane potential by complex II-energized mitochondria of obese, diabetic mice assessed using ADP recycling methodology. Am J Physiol Regul Integr Comp Physiol 311:756-63. | Mouse | Skeletal muscle |
| Cahova 2016 Am J Physiol Gastrointest Liver Physiol | 2016 | Cahova M, Palenickova E, Dankova H, Sticova E, Burian M, Drahota Z, Cervinkova Z, Kucera O, Gladkova C, Stopka P, Krizova J, Papackova Z, Oliyarnyk O, Kazdova L (2016) Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. Am J Physiol Gastrointest Liver Physiol 309:G100-11. | Rat | Liver |
| Lalia 2016 J Clin Endocrinol Metab | 2016 | Lalia AZ, Dasari S, Johnson ML, Robinson MM, Konopka AR, Distelmaier K, Port JD, Glavin MT, Esponda RR, Nair KS, Lanza IR (2016) Predictors of whole-body insulin sensitivity across ages and adiposity in adult humans. J Clin Endocrinol Metab 101:626-34. | Human | Skeletal muscle |
| Sperrin 2016 J Public Health (Oxf) | 2016 | Sperrin M, Marshall AD, Higgins V, Renehan AG, Buchan IE (2016) Body mass index relates weight to height differently in women and older adults: serial cross-sectional surveys in England (1992-2011). J Public Health (Oxf) 38:607-613. | Human | |
| Apovian 2016 Am J Manag Care | 2016 | Apovian CM (2016) Obesity: definition, comorbidities, causes, and burden. Am J Manag Care 22(7 Suppl):s176–85. | Human | |
| Chu 2016 World J Gastroenterol | 2016 | Chu MJ, Premkumar R, Hickey AJ, Jiang Y, Delahunt B, Phillips AR, Bartlett A (2016) Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-I dysfunction. World J Gastroenterol 22:4673-84. | Rat | Liver |
| Magdalon 2016 Biochim Biophys Acta | 2016 | Magdalon J, Chimin P, Belchior T, Neves RX, Vieira-Lara MA, Andrade ML, Farias TS, Bolsoni-Lopes A, Paschoal VA, Yamashita AS, Kowaltowski AJ, Festuccia WT (2016) Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice. Biochim Biophys Acta 1861:430-8. | Mouse | Fat |
| Chondronikola 2016 Cell Metab | 2016 | Chondronikola M, Volpi E, Børsheim E, Porter C, Saraf MK, Annamalai P, Yfanti C, Chao T, Wong D, Shinoda K, Labbė SM, Hurren NM, Cesani F, Kajimura S, Sidossis LS. (2016) Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans. Cell Metab 23:1200-6. | Human | |
| Safiedeen 2016 Antioxid Redox Signal | 2016 | Safiedeen Z, Rodríguez-Gómez I, Vergori L, Soleti R, Vaithilingam D, Douma I, Agouni A, Leiber D, Dubois S, Simard G, Zibara K, Andriantsitohaina R, Martínez MC (2016) Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction. Antioxid Redox Signal 26:15-27. | Human | Endothelial;epithelial;mesothelial cell |
| Lund 2016 J Physiol | 2016 | Lund MT, Kristensen M, Hansen M, Tveskov L, Floyd AK, Støckel M, Vainer B, Poulsen SS, Helge JW, Prats C, Dela F (2016) Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes. J Physiol 594:4351-8. | Human | Liver |
| Gariani 2016 Hepatology | 2016 | Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku SC, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J (2016) Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease. Hepatology 63:1190-204. | Mouse | Liver |
| Snook 2016 Am J Physiol Regul Integr Comp Physiol | 2016 | Snook LA, MacPherson RE, Monaco CM, Frendo-Cumbo S, Castellani L, Peppler WT, Anderson ZG, Buzelle SL, LeBlanc PJ, Holloway GP, Wright DC (2016) Prior exercise training blunts short term highfat diet induced weight gain. Am J Physiol Regul Integr Comp Physiol 311:R315-24. | Mouse | Fat |
| Yavari 2016 Cell Metab | 2016 | Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martinez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Toth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H (2016) Chronic activation of γ2 AMPK induces obesity and reduces β cell function. Cell Metab 23:821-36. | Mouse | Nervous system |
| Morton 2016 Nat Med | 2016 | Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S (2016) Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med 22:771-9. | Mouse | Liver |
| Giraldos Jimenez 2016 Thesis | 2016 | Giraldos Jiménez D (2016) Oxidative phosphorylation system’s role in adipogenic differentiation. Thesis p25. | ||
| Iwaniec 2016 J Endocrinol | 2016 | Iwaniec UT, Turner RT (2016) Influence of body weight on bone mass, architecture and turnover. J Endocrinol 230: R115-30. | Human Mouse | Fat |
| Kroenke 2016 JAMA Oncol | 2016 | Kroenke CH, Neugebauer R, Meyerhardt J, Prado CM, Weltzien E, Kwan ML, Xiao J, Caan BJ ( 2016) Analysis of body mass index and mortality in patients with colorectal cancer using causal diagrams. JAMA Oncol 2:1137–45. | Human | |
| Hanssen 2015 Diabetes | 2015 | Hanssen MJ, van der Lans AA, Brans B, Hoeks J, Jardon KM, Schaart G, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2015) Short-term cold acclimation recruits brown adipose tissue in obese humans. Diabetes 65:1179-89. | Human | Skeletal muscle |
| Wessels 2015 Diabetes Obes Metab | 2015 | Wessels B, Ciapaite J, van den Broek NM, Houten SM, Nicolay K, Prompers JJ (2015) Pioglitazone treatment restores in vivo muscle oxidative capacity in a rat model of diabetes. Diabetes Obes Metab 17:52-60. | Rat | Skeletal muscle |
| Fritsch 2015 Am J Clin Nutr | 2015 | Fritsch M, Koliaki C, Livingstone R, Phielix E, Bierwagen A, Meisinger M, Jelenik T, Strassburger K, Zimmermann S, Brockmann K, Wolff C, Hwang JH, Szendroedi J, Roden M (2015) Time course of postprandial hepatic phosphorus metabolites in lean, obese, and type 2 diabetes patients. Am J Clin Nutr 102:1051-8. | Human | Skeletal muscle |
| Baraldi 2015 J Nutr Biochem | 2015 | Baraldi FG, Vicentini TM, Teodoro BG, Dalalio FM, Dechandt CR, Prado IM, Curti C, Cardoso FC, Uyemura SA, Alberici LC (2015) The combination of conjugated linoleic acid (CLA) and extra virgin olive oil increases mitochondrial and body metabolism and prevents CLA-associated insulin resistance and liver hypertrophy in C57Bl/6 mice. J Nutr Biochem 28:147-54. | Mouse | Liver |
| Chondronikola 2015 Int J Obes (Lond) | 2015 | Chondronikola M, Annamalai P, Chao T, Porter C, Saraf MK, Cesani F, Sidossis LS (2015) A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans.. Int J Obes (Lond) 39(10):1561-4. | Human | Fat |
| Hansen 2015 Obesity (Silver Spring) | 2015 | Hansen M, Lund MT, Gregers E, Kraunsøe R, Van Hall G, Helge JW, Dela F (2015) Adipose tissue mitochondrial respiration and lipolysis before and after a weight loss by diet and RYGB. Obesity (Silver Spring) 23:2022-9. | Human | Fat |
| Pedersen 2015 Scand J Med Sci Sports | 2015 | Pedersen BK, Saltin B (2015) Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports 25:1-72. https://doi.org/10.1111/sms.12581 | Human | |
| Tompuri 2015 Clin Physiol Funct Imaging | 2015 | Tompuri T, Lintu N, Savonen K, Laitinen T, Laaksonen D, Jääskeläinen J, Lakka TA (2015) Measures of cardiorespiratory fitness in relation to measures of body size and composition among children. Clin Physiol Funct Imaging 35:469-77. | Human | |
| Sheldon 2015 Am J Physiol Gastrointest Liver Physiol | 2015 | Sheldon RD, Padilla J, Jenkins NT, Laughlin MH, Rector RS (2015) Chronic NOS inhibition accelerates NAFLD progression in an obese rat model. Am J Physiol Gastrointest Liver Physiol 308:G540-9. | Rat | Liver |
| Indian Academy of Pediatrics Growth Charts Committee 2015 Indian Pediatr | 2015 | Indian Academy of Pediatrics Growth Charts Committee, Khadilkar V, Yadav S, Agrawal KK, Tamboli S, Banerjee M, Cherian A, Goyal JP, Khadilkar A, Kumaravel V, Mohan V, Narayanappa D, Ray I, Yewale V (2015) Revised IAP growth charts for height, weight and body mass index for 5- to 18-year-old Indian children. Indian Pediatr 52:47-55. | Human | |
| Den Besten 2015 Diabetes | 2015 | den Besten G, Bleeker A, Gerding A, van Eunen K, Havinga R, van Dijk TH, Oosterveer MH, Jonker JW, Groen AK, Reijngoud DJ, Bakker BM (2015) Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes 64:2398-408. | Mouse | Liver |
| Joergensen 2015 J Cereb Blood Flow Metab | 2015 | Jørgensen T, Grunnet N, Quistorff B (2015) One-year high fat diet affects muscle-but not brain mitochondria. J Cereb Blood Flow Metab 35:943-50. | Rat | Skeletal muscle Nervous system |
| Benito 2015 J Appl Physiol | 2015 | Benito PJ, Bermejo LM, Peinado AB, López-Plaza B, Cupeiro R, Szendrei B, Calderón FJ, Castro EA, Gómez-Candela C, on behalf of the PRONAF Study Group (2015) Change in weight and body composition in obese subjects following a hypocaloric diet plus different training programs or physical activity recommendations. J Appl Physiol 118:1006-13. | Human | Skeletal muscle |
| Seillier 2015 EMBO Mol Med | 2015 | Seillier M, Pouyet L, N'Guessan P, Nollet M, Capo F, Guillaumond F, Peyta L, Dumas JF, Varrault A, Bertrand G, Bonnafous S, Tran A, Meur G, Marchetti P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A (2015) Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med 7:802-18. | Human Mouse | Fibroblast |
| Beauchamp 2015 Biosci Rep | 2015 | Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper ME (2015) Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep 35. pii:e00200. | Mouse | Heart Liver |
| Agil 2015 J Pineal Res | 2015 | Agil A, El-Hammadi M, Jiménez-Aranda A, Tassi M, Abdo W, Fernández-Vázquez G, Reiter RJ (2015) Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats. J Pineal Res 59:70-9. | Rat | Liver |
| Conner 2015 FASEB J | 2015 | Conner B, Hetrik B, Chicco A, McCurdy C (2015) Maternal obesity alters offspring muscle mitochondrial function in nonhuman primates. FASEB J 29:1036.7. | Other mammals | Skeletal muscle |
| Koliaki 2015 Cell Metab | 2015 | Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M (2015) Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab 21:739-46. | Human | Liver |
| Katunga 2015 Mol Metab | 2015 | Katunga LA, Gudimella P, Efird JT, Abernathy S, Mattox TA, Beatty C, Darden TM, Thayne KA, Alwair H, Kypson AP, Virag JA, Anderson EJ (2015) Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy. Mol Metab 4:493-506. | Mouse | Heart |
| Al-Gindan 2015 Br J Nutr | 2015 | Al-Gindan YY, Hankey CR, Govan L, Gallagher D, Heymsfield SB, Lean ME (2015) Derivation and validation of simple anthropometric equations to predict adipose tissue mass and total fat mass with MRI as the reference method. Br J Nutr 114:1852-67. | Human | Fat |
| Acosta 2015 Obesity (Silver Spring) | 2015 | Acosta A, Camilleri M, Shin A, Vazquez-Roque MI, Iturrino J, Lanza IR, Nair KS, Burton D, O'Neill J, Eckert D, Carlson P, Vella A, Zinsmeister AR (2015) Association of UCP-3 rs1626521 with obesity and stomach functions in humans. Obesity (Silver Spring) 23:898-906. | Human | Skeletal muscle |
| Lisak 2015 Cell Death Differ | 2015 | Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, Gliem M, Hofstetter HH, Zanger K, Bultynck G, Parys JB, De Smedt H, Kindler T, Adams-Quack P, Hahn M, Waisman A, Reed JC, Hövelmeyer N, Methner A (2015) BAX inhibitor-1 is a Ca2+ channel critically important for immune cell function and survival. Cell Death Differ 23:358-68. | Mouse | Blood cells Lymphocyte |
| Coen 2015 Diabetes | 2015 | Coen PM, Menshikova EV, Distefano G, Zheng D, Tanner CJ, Standley RA, Helbling NL, Dubis GS, Ritov VB, Xie H, Desimone ME, Smith SR, Stefanovic-Racic M, Toledo FG, Houmard JA, Goodpaster BH (2015) Exercise and weight loss improve muscle mitochondrial respiration, lipid partitioning, and insulin sensitivity after gastric bypass surgery. Diabetes 64:3737-50. | Human | Skeletal muscle |
| Woodlief 2015 Obesity (Silver Spring) | 2015 | Woodlief TL, Carnero EA, Standley RA, Distefano G, Anthony SJ, Dubis GS, Jakicic JM, Houmard JA, Coen PM, Goodpaster BH (2015) Dose response of exercise training following roux-en-Y gastric bypass surgery: A randomized trial. Obesity (Silver Spring) 23:2454-61. | Human | Skeletal muscle |
| Wessels 2015 Am J Physiol | 2015 | Wessels B, van den Broek NM, Ciapaite J, Houten SM, Wanders RJA, Nicolay K, Prompers JJ (2015) Carnitine supplementation in high-fat diet-fed rats does not ameliorate lipid-induced skeletal muscle mitochondrial dysfunction in vivo. Am J Physiol 309(7):E670-8. | Rat | Skeletal muscle |
| Nevill 2015 Nutr Diabetes | 2015 | Nevill AM, Metsios GS (2015) The need to redefine age- and gender-specific overweight and obese body mass index cutoff points. Nutr Diabetes 5:e186. | Human | Fat |
| Cappel 2015 PLoS One | 2015 | Cappel DA, Lantier L, Palmisano BT, Wasserman DH, Stafford JM (2015) CETP expression protects female mice from obesity-induced decline in exercise capacity. PLoS One 10:e0136915. | Mouse | Skeletal muscle |
| Schoettl 2015 Mol Metab | 2015 | Schöttl T, Kappler L, Fromme T, Klingenspor M (2015) Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status. Mol Metab 4:631-42. | Mouse | Fat Other cell lines |
| Tyrrell 2015 Exp Gerontol | 2015 | Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ (2015) Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol 70:84-91. | Human | Blood cells Lymphocyte |
| Konopka 2015 Diabetes | 2015 | Konopka AR, Asante A, Lanza IR, Robinson MM, Johnson ML, Dalla Man C, Cobelli C, Amols MH, Irving BA, Nair KS (2015) Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training. Diabetes 64:2104-15. | Human | Skeletal muscle |
| Bonhoure 2015 Genes Dev | 2015 | Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM1 (2015) Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes Dev 29:934-47. | Mouse | Liver |
| Chaix 2014 Cell Metab | 2014 | Chaix A, Zarrinpar A, Miu P, Panda S (2014) Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab 20:991-1005. | Mouse | |
| Feng 2014 Am J Physiol Cell Physiol | 2014 | Feng YZ, Nikolić N, Bakke SS, Kase ET, Guderud K, Hjelmesæth J, Aas V, Rustan AC, Thoresen GH (2014) Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise. Am J Physiol Cell Physiol 308:C548-56. | Human | Skeletal muscle |
| Hirzel 2014 PhD Thesis | 2014 | Hirzel E (2014) Characterization of human bone marrow derived mesenchymal stem cells as a model for in vitro adipocytes studies. PhD Thesis 1-106. | Human | Fat Other cell lines |
| Rudnicki 2014 United States Patent Application Publication | 2014 | Rudnicki MA, Yin Hang (2014) MICRORNA INHIBITORS. United States Patent Application Publication 1-49. | Mouse | Skeletal muscle Fat |
| Serteyn 2014 Bioenergetics | 2014 | Serteyn D, de la Rebière de Pouyade G, Sandersen C, Salciccia A, Grulke S, Mouithys-Mickalad A, Franck T, Lejeune JP, Ceusters Justine D (2014) Muscle mitochondrial dysfunction in horses affected by acute laminitis. Bioenergetics 3:1-7. | Horse | Skeletal muscle |
| Frederick 2014 J Biol Chem | 2014 | Frederick DW, Davis JG, Dávila A Jr, Agarwal B, Michan S, Puchowicz MA, Nakamaru-Ogiso E, Baur JA (2014) Increasing NAD synthesis in muscle via nicotinamide phosphoribosyltransferase is not sufficient to promote oxidative metabolism.. J Biol Chem. 290:1546-58. | Mouse | Skeletal muscle |
| Abdurrachim 2014 Biochim Biophys Acta | 2014 | Abdurrachim D, Ciapaite J, Wessels B, Nabben M, Luiken JJ, Nicolay K, Prompers JJ (2014) Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochim Biophys Acta 1842:1525-37. | Mouse | Heart |
| Chondronikola 2014 | 2014 | Chondronikola M, Volpi E, Børsheim E, Porter C, Annamalai P, Enerbäck S, Lidell ME, Saraf MK, Labbe SM, Hurren NM, Yfanti 7, Chao T, Andersen CR, Cesani F, Hawkins H, Sidossis LS. (2014) Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes 63(12):4089-99. | Human | Fat |
| Neves 2014 J Nutr Biochem | 2014 | Neves FA, Cortez E, Bernardoa AF, Mattos ABM, Vieira AK, Malafaia TO, Thole AA, Rodrigues-Cunha ACS, Garcia-Souza EP, Sichieri R, Moura AS (2014) Heart energy metabolism impairment in Western-diet induced obese mice. J Nutr Biochem 25:50-57. | Mouse | Heart |
| Hoevenaars 2014 Mol Nutr Food Res | 2014 | Hoevenaars FP, Bekkenkamp-Grovenstein M, Janssen RJ, Heil SG, Bunschoten A, Hoek-van den Hil EF, Snaas-Alders S, Teerds K, van Schothorst EM, Keijer J (2014) Thermoneutrality results in prominent diet-induced body weight differences in C57BL/6J mice, not paralleled by diet-induced metabolic differences. Mol Nutr Food Res 58:799-807. | Mouse | Skeletal muscle |
| Yin 2014 J Clin Endocrinol Metab | 2014 | Yin X, Lanza IR, Swain JM, Sarr MG, Nair KS, Jensen MD (2014) Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size. J Clin Endocrinol Metab 99:E209-16. | Human | Fat |
| Phielix 2014 Diabetologia | 2014 | Phielix E, Jelenik T, Nowotny P, Szendroedi J, Roden M (2014) Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: a randomised clinical trial. Diabetologia 57:572-81. | Human | Skeletal muscle |
| De Sousa 2014 Stem Cells | 2014 | De Sousa M, Porras DP, Perry CG, Seale P, Scimè A. (2014) p107 is a crucial regulator for determining the adipocyte lineage fate choices of stem cells. Stem Cells 32:1323-36. | Mouse | Other cell lines |
| Zeng 2014 Br J Nutr | 2014 | Zeng Q, He Y, Dong S, Zhao X, Chen Z, Song Z, Chang G, Yang F, Wang Y (2014) Optimal cut-off values of BMI, waist circumference and waist:height ratio for defining obesity in Chinese adults. Br J Nutr 112:1735-44. | Human | |
| Jimenez-Aranda 2014 J Pineal Res | 2014 | Jimenéz-Aranda A, Fernández-Vázquez G, Serrano MM, Reiter RJ, Agil A (2014) Melatonin improves mitochondrial function in inguinal white adipose tissue of Zücker diabetic fatty rats. J Pineal Res 57:103-9. | Rat | Fat |
| Casanova 2014 J Nutr Biochem | 2014 | Casanova E, Baselga-Escudero L, Ribas-Latre A, Cedó L, Arola-Arnal A, Pinent M, Bladé C, Arola L, Salvadó MJ (2014) Chronic intake of proanthocyanidins and docosahexaenoic acid improves skeletal muscle oxidative capacity in diet-obese rats. J Nutr Biochem 25:1003–10. | Rat | Skeletal muscle |
| Mialich 2014 Nutr Hosp | 2014 | Mialich MS, Martinez EZ, Jordao JJ (2014) Application of body mass index adjusted for fat mass (BMIfat) obtained by bioelectrical impedance in adults. Nutr Hosp 30:417-24. | Human | Fat |
| Svendsen 2014 Thesis | 2014 | Svendsen PF (2014) Metabolic aspects of polycystic ovary syndrome and obesity. Thesis Copenhagen University Hospital:38 pp. | Human | |
| Keys 2014 Int J Epidemiol | 2014 | Keys A, Fidanza F, Karvonen MJ, Kimura N, Taylor HL (2014) Indices of relative weight and obesity. Int J Epidemiol 43:655-65. | Human | Fat |
| Genne-Bacon 2014 Yale J Biol Med | 2014 | Genné-Bacon EA (2014) Thinking evolutionarily about obesity. Yale J Biol Med 87:99-112. | Human | |
| Goodpaster 2014 Diabetes | 2014 | Goodpaster BH, Coen PM (2014) Improved mitochondrial function is linked with improved insulin sensitivity through reductions in FFA. Diabetes 63:2611-2. | ||
| Nigro 2014 Endocrinology | 2014 | Nigro M, Santos AT, Barthem CS, Louzada RA, Fortunato RS, Ketzer LA, Carvalho DP, de Meis L (2014) A change in liver metabolism but not in brown adipose tissue thermogenesis is an early event in ovariectomy-induced obesity in rats. Endocrinology 155:2881-91. | Rat | Fat |
| Littlejohns 2014 PLoS One | 2014 | Littlejohns B, Pasdois P, Duggan S, Bond AR, Heesom K, Jackson CL, Angelini GD, Halestrap AP, Suleiman MS (2014) Hearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion injury. PLoS One 9:e100579. | Mouse | Heart |
| Chu 2014 PLoS One | 2014 | Chu MJ, Hickey AJ, Tagaloa S, Zhang L, Dare AJ, MacDonald JR, Yeong ML, Bartlett AS, Phillips AR (2014) Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia. PLoS One 9:e100609. | Mouse | Liver |
| Montaigne 2014 Circulation | 2014 | Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, Potelle C, El Arid JM, Mouton S, Sebti Y, Duez H, Preau S, Remy-Jouet I, Zerimech F, Koussa M, Richard V, Neviere R, Edme JL, Lefebvre P, Staels B (2014) Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in Type 2 Diabetic but not in obese patients. Circulation 130:554-64. | Human | Heart |
| Zachariah 2014 Diabetes | 2014 | Zachariah Tom R, Garcia-Roves PM, Sjögren RJ, Jiang LQ, Holmström MH, Deshmukh AS, Vieira E, Chibalin AV, Björnholm M, Zierath JR (2014) Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice. Diabetes 63:1560-71. | Mouse | Skeletal muscle |
| Yan 2014 J Diabetes Res | 2014 | Yan LJ (2014) Pathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress. J Diabetes Res 2014:137919. https://doi.org/10.1155/2014/137919 | ||
| Kuper 2014 BMC Public Health | 2014 | Kuper H, Taylor A, Krishna KV, Ben-Shlomo Y, Gupta R, Kulkarni B, Prabhakaran D, Davey Smith G, Wells J, Ebrahim S, Kinra S (2014) Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity. BMC Public Health 14:1239. | Human | Fat |
| Garnol 2014 Physiol Res | 2014 | Garnol T, Endlicher R, Kučera O, Drahota Z, Cervinková Z (2014) Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress. Physiol Res 63:271-4. | Rat | Liver |
| Holmstroem 2013 Metabolism | 2013 | Holmström MH, Tom RZ, Björnholm M, Garcia-Roves PM, Zierath JR (2013) Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice. Metabolism 62:1258-67. | Mouse | Skeletal muscle Liver |
| Schneeberger 2013 Cell | 2013 | Schneeberger M, Dietrich MO, Sebastián D, Imbernón M, Castaño C, Garcia A, Esteban Y, Gonzalez-Franquesa A, Rodríguez IC, Bortolozzi A, Garcia-Roves PM, Gomis R, Nogueiras R, Horvath TL, Zorzano A, Claret M (2013) Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell 155:172-87. | Mouse | Nervous system |
| Dahl-Petersen 2013 Diabetes Res Clin Pract | 2013 | Dahl-Petersen IK, Bjerregaard P, Brage S, Jørgensen ME (2013) Physical activity energy expenditure is associated with 2-h insulin independently of obesity among Inuit in Greenland. Diabetes Res Clin Pract 102:242-9. | Human | |
| Sitnick 2013 Diabetes | 2013 | Sitnick MT, Basantani MK, Cai L, Schoiswohl G, Yazbeck CF, Distefano G, Ritov V, Delany JP, Schreiber R, Stolz DB, Gardner NP, Kienesberger PC, Pulinilkunnil T, Zechner R, Goodpaster BH, Coen P, Kershaw EE (2013) Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes 62:3350-6. | Mouse | Skeletal muscle |
| Montaigne 2013 J Am Coll Cardiol | 2013 | Montaigne D, Marechal X, Lefebvre P, Modine T, Fayad G, Dehondt H, Hurt C, Coisne A, Koussa M, Remy-Jouet I, Zerimech F, Boulanger E, Lacroix D, Staels B, Neviere R (2013) Mitochondrial dysfunction as an arrhythmogenic substrate. J Am Coll Cardiol 62:1466-73. | Human | Heart |
| Toledo 2013 Mol Cell Endocrinol | 2013 | Toledo FG, Goodpaster BH (2013) The role of weight loss and exercise in correcting skeletal muscle mitochondrial abnormalities in obesity, diabetes and aging. Mol Cell Endocrinol 379:30-4. | Human | |
| Koliaki 2013 Mol Cell Endocrinol | 2013 | Koliaki C, Roden M (2013) Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic fatty liver disease. Mol Cell Endocrinol 379:35-42. | Human | Liver |
| Miranda 2013 Thesis Instituto de Biologia - Rio de Janeiro | 2013 | Miranda GL (2013) Sinalização da grelina no coração de camundongos obesos após hipernutrição durante a lactação / Ghrelin signaling in the heart of obese mice after overnutrition during lactation. Thesis Instituto de Biologia - Rio de Janeiro 93pp. | Mouse | |
| Weber 2013 Thesis East Carolina University | 2013 | Weber T (2013) The effect of contractile activity and substrate challenges on metabolic flexibility in human primary myotubes. Thesis East Carolina University - USA:105 pp. | Human | Skeletal muscle Other cell lines |
| Vijgen 2013 J Clin Endocrinol Metab | 2013 | Vijgen GH, Sparks LM, Bouvy ND, Schaart G, Hoeks J, van Marken Lichtenbelt WD, Schrauwen P (2013) Increased oxygen consumption in human adipose tissue from the "brown adipose tissue" region. J Clin Endocrinol Metab 98:E1230-4. | Human | Fat |
| Vijgen 2013 Surg Obes Relat Dis | 2013 | Vijgen GH, Bouvy ND, Hoeks J, Wijers S, Schrauwen P, van Marken Lichtenbelt WD (2013) Impaired skeletal muscle mitochondrial function in morbidly obese patients is normalized one year after bariatric surgery. Surg Obes Relat Dis 9:936-41. | Human | Skeletal muscle |
| Johnson 2013 Obesity (Silver Spring) | 2013 | Johnson RJ, Stenvinkel P, Martin SL, Jani A, Sánchez-Lozada LG, Hill JO, Lanaspa MA (2013) Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology. Obesity (Silver Spring) 21:659-64. | Human | |
| Setty 2013 Int J Med Sci Public Health | 2013 | Setty P, Padmanabha BV, Doddamani BR (2013) Correlation between obesity and cardio respiratory fitness. Int J Med Sci Public Health 2:300-4. | Human | |
| Andersen 2013 Int J Circumpolar Health | 2013 | Andersen S, Fleischer Rex K, Noahsen P, Sørensen HC, Mulvad G, Laurberg P (2013) Raised BMI cut-off for overweight in Greenland Inuit--a review. Int J Circumpolar Health 2013 Aug 5;72. doi: 10.3402/ijch.v72i0.21086. | ||
| Arora 2013 Pediatr Obes | 2013 | Arora T, Hosseini-Araghi M, Bishop J, Yao GL, Thomas GN, Taheri S (2013) The complexity of obesity in UK adolescents: relationships with quantity and type of technology, sleep duration and quality, academic performance and aspiration. Pediatr Obes 8:358-66. | Human | |
| Hernandez-Aguilera 2013 Mediators Inflamm | 2013 | Hernández-Aguilera A, Rull A, Rodríguez-Gallego E, Riera-Borrull M, Luciano-Mateo F, Camps J, Menéndez JA, Joven J (2013) Mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities. Mediators Inflamm 2013:135698. | Human | Fat |
| Rindler 2013 J Biol Chem | 2013 | Rindler PM, Plafker SM, Szweda LI, Kinter M (2013) High dietary fat selectively increases catalase expression within cardiac mitochondria. J Biol Chem 288:1979-90. | Mouse | Heart |
| Van Eunen 2013 PLoS Comput Biol | 2013 | van Eunen K, Simons SM, Gerding A, Bleeker A, den Besten G, Touw CM, Houten SM, Groen BK, Krab K, Reijngoud DJ, Bakker BM (2013) Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload. PLoS Comput Biol 9:e1003186. | Rat | Liver |
| Holmstroem 2012 Am J Physiol Endocrinol Metab | 2012 | Holmstroem MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM (2012) Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab 302:E731-9. | Mouse | Skeletal muscle Liver |
| Votion 2012 PLoS One | 2012 | Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7:e34890. https://doi.org/10.1371/journal.pone.0034890 | Horse | Skeletal muscle |
| Fisher-Wellman 2012 Trends Endocrinol Metab | 2012 | Fisher-Wellman KH, Neufer PD (2012) Linking mitochondrial bioenergetics to insulin resistance via redox biology. Trends Endocrinol Metab 23:142-53. https://doi.org/10.1016/j.tem.2011.12.008 | ||
| Thomas 2012 Nutr Res Rev | 2012 | Thomas EL, Frost G, Taylor-Robinson SD, Bell JD (2012) Excess body fat in obese and normal-weight subjects. Nutr Res Rev 25:150–61. | Human | Fat |
| Santilli 2012 Obes Rev | 2012 | Santilli F, Vazzana N, Liani R, Guagnano MT, Davì G (2012) Platelet activation in obesity and metabolic syndrome. Obes Rev 13:27-42. https://doi.org/10.1111/j.1467-789X.2011.00930.x | Human | Blood cells Platelet |
| Stephenson 2012 Am J Physiol Endocrinol Metab | 2012 | Stephenson EJ, Camera DM, Jenkins TA, Lee JS, Kosari S, Hawley JA, Stepto NK (2012) Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet. Am J Physiol Endocrinol Metab 302:E1541-49. | Rat | Skeletal muscle |
| Sebastian 2012 Proc Natl Acad Sci U S A | 2012 | Sebastián D, Hernández-Alvarez MI, Segalés J, Sorianello E, Muñoz JP, Sala D, Waget A, Liesa M, Paz JC, Gopalacharyulu P, Orešič M, Pich S, Burcelin R, Palacín M, Zorzano A (2012) Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc Natl Acad Sci U S A 109:5523-8. | Human Mouse | Skeletal muscle Liver |
| Egger 2012 Econ Hum Biol | 2012 | Egger G, Swinburn B, Islam FM (2012) Economic growth and obesity: an interesting relationship with world-wide implications. Econ Hum Biol 10:147-53. | ||
| Timmers 2011 Cell Metab | 2011 | Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen P (2011) Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 14:612-22. | Human | Skeletal muscle |
| Boyle 2011 Int J Obes | 2011 | Boyle KE, Zheng D, Anderson EJ, Neufer PD, Houmard JA (2011) Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans. Int J Obes 36:1025-31. | Human | Skeletal muscle |
| Bergman 2011 Obesity (Silver Spring) | 2011 | Bergman RN, Stefanovski D, Buchanan TA, Sumner AE, Reynolds JC, Sebring NG, Xiang AH, Watanabe RM (2011) A better index of body adiposity. Obesity (Silver Spring) 19:1083-9. | Human | Fat |
| Chomentowski 2011 J Clin Endocrinol Metab | 2011 | Chomentowski P, Coen PM, Radiková Z, Goodpaster BH, Toledo FG (2011) Skeletal muscle mitochondria in insulin resistance: Differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility. J Clin Endocrinol Metab 96: 494-503. | Human | Skeletal muscle |
| Goetzman 2011 Prog Mol Biol Transl Sci | 2011 | Goetzman ES (2011) Modeling disorders of fatty acid metabolism in the mouse. Prog Mol Biol Transl Sci 100:389-417. https://doi.org/10.1016/B978-0-12-384878-9.00010-8 | Mouse | |
| Pajuelo-Reguera 2011 Br J Nutr | 2011 | Pajuelo-Reguera D, Quesada H, Díaz S, Fernández-Iglesias A, Arola-Arnal A, Bladé C, Salvadó J, Arola L (2011) Chronic dietary supplementation of proanthocyanidins corrects the mitochondrial dysfunction of brown adipose tissue caused by diet-induced obesity in Wistar rats. Br J Nutr 28:1-9. | Rat | Fat |
| Pesta 2011 Am J Physiol Regul Integr Comp Physiol | 2011 | Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87. | Human | Skeletal muscle |
| Misra 2011 Int J Obes (Lond) | 2011 | Misra A, Khurana L (2011) Obesity-related non-communicable diseases: South Asians vs White Caucasians. Int J Obes (Lond) 35:167–87. | Human | Fat |
| Roth 2010 Aging (Albany NY) | 2010 | Flach RJ, Bennett AM (2010) MAP kinase phosphatase-1 - a new player at the nexus between sarcopenia and metabolic disease. Aging (Albany NY) 2:170-6. | ||
| Kraunsoee 2010 J Physiol | 2010 | Kraunsøe R, Boushel RC, Hansen CN, Schjerling P, Qvortrup K, Støckel M, Mikines KJ, Dela F (2010) Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. J Physiol 588:2023-32. | Human | Fat |
| Mancuso 2010 J Biol Chem | 2010 | Mancuso DJ, Sims HF, Yang K, Kiebish MA, Su X, Jenkins CM, Guan S, Moon SH, Pietka T, Nassir F, Schappe T, Moore K, Han X, Abumrad NA, Gross RW (2010) Genetic ablation of calcium-independent phospholipase A2{gamma} prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation. J Biol Chem 285:36495-510. | Mouse | Skeletal muscle Fat |
| Meeuwsen 2010 Clin Nutr | 2010 | Meeuwsen S, Horgan GW, Elia M (2010) The relationship between BMI and percent body fat, measured by bioelectrical impedance, in a large adult sample is curvilinear and influenced by age and sex. Clin Nutr 29:560-6. | Human | Fat |
| Remels 2010 FASEB J | 2010 | Remels AH, Gosker HR, Schrauwen P, Hommelberg PP, Sliwinski P, Polkey M, Galdiz J, Wouters EF, Langen RC, Schols AM (2010) TNF-alpha impairs regulation of muscle oxidative phenotype: Implications for cachexia? FASEB J 12:5052-62. | Human | Skeletal muscle |
| Wang 2010 Biomed Environ Sci | 2010 | Wang C, Hou XH, Zhang ML, Bao YQ, Zou YH, Zhong WH, Xiang KS, Jia WP (2010) Comparison of body mass index with body fat percentage in the evaluation of obesity in Chinese. Biomed Environ Sci 23:173-9. | Human | |
| Hassing 2010 Dement Geriatr Cogn Disord | 2010 | Hassing LB, Dahl AK, Pedersen NL, Johansson B (2010) Overweight in midlife is related to lower cognitive function 30 years later: a prospective study with longitudinal assessments. Dement Geriatr Cogn Disord 29:543-52. | Human | |
| Pribis 2010 Nutrients | 2010 | Pribis P, Burtnack CA, McKenzie SO, Thayer J (2010) Trends in body fat, body mass index and physical fitness among male and female college students. Nutrients 2:1075-85. | Human | |
| Corpeleijn 2010 Am J Physiol Endocrinol Metab | 2010 | Corpeleijn E, Hessvik NP, Bakke SS, Levin K, Blaak EE, Thoresen GH, Gaster M, Rustan AC (2010) Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids. Am J Physiol Endocrinol Metab 299:E14-22. | Human | Skeletal muscle |
| Sabia 2009 Am J Clin Nutr | 2009 | Sabia S, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A (2009) Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study. Am J Clin Nutr 89:601-7. | Human | |
| Bosy-Westphal 2009 Br J Nutr | 2009 | Bosy-Westphal A, Plachta-Danielzik S, Dörhöfer RP, Müller MJ (2009) Short stature and obesity: positive association in adults but inverse association in children and adolescents. Br J Nutr 102:453-61. | Fat | |
| Volkow 2009 Obesity (Silver Spring) | 2009 | Volkow ND, Wang GJ, Telang F, Fowler JS, Goldstein RZ, Alia-Klein N, Logan J, Wong C, Thanos PK, Ma Y, Pradhan K (2009) Inverse association between BMI and prefrontal metabolic activity in healthy adults. Obesity (Silver Spring) 17:60-5. | Human | Nervous system |
| Romanatto 2009 J Biol Chem | 2009 | Romanatto T, Roman EA, Arruda AP, Denis RG, Solon C, Milanski M, Moraes JC, Bonfleur ML, Degasperi GR, Picardi PK, Hirabara S, Boschero AC, Curi R, Velloso LA (2009) Deletion of tumor necrosis factor-alpha-receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem 284:36213-22. | Rat | Skeletal muscle |
| Gnaiger 2009 Int J Biochem Cell Biol | 2009 | Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45. https://doi.org/10.1016/j.biocel.2009.03.013 | Human Mouse | Skeletal muscle |
| Kodama 2009 JAMA | 2009 | Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H (2009) Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA 301:2024-35. | Human | |
| Misra 2009 J Assoc Physicians India | 2009 | Misra A, Chowbey P, Makkar BM, Vikram NK, Wasir JS, Chadha D, Joshi Shashank R, Sadikot S, Gupta R, Gulati Seema, Munjal YP, Concensus Group (2009) Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. J Assoc Physicians India 57:163–70. | Human | Fat |
| Walley 2009 Nat Rev Genet | 2009 | Walley AJ, Asher JE, Froguel P (2009) The genetic contribution to non-syndromic human obesity. Nat Rev Genet 10:431–42. | Human | |
| Hoeks 2008 FEBS Lett | 2008 | Hoeks J, Briedé JJ, de Vogel J, Schaart G, Nabben M, Moonen-Kornips E, Hesselink MK, Schrauwen P (2008) Mitochondrial function, content and ROS production in rat skeletal muscle: Effect of high-fat feeding. FEBS Lett 582:510-16. | Rat | Skeletal muscle |
| Romero-Corral 2008 Int J Obes (Lond) | 2008 | Romero-Corral A, Somers VK, Sierra-Johnson J, Thomas RJ, Collazo-Clavell ML, Korinek J, Allison TG, Batsis JA, Sert-Kuniyoshi FH, Lopez-Jimenez F (2008) Accuracy of body mass index in diagnosing obesity in the adult general population. Int J Obes (Lond) 32:959-66. | Human | Fat |
| Kus 2008 Am J Physiol Endocrinol Metab | 2008 | Kus V, Prazak T, Brauner P, Hensler M, Kuda O, Flachs P, Janovska P, Medrikova D, Rossmeisl M, Jilkova Z, Stefl B, Pastalkova E, Drahota Z, Houstek J, Kopecky J (2008) Induction of muscle thermogenesis by high-fat diet in mice: Association with obesity-resistance. Am J Physiol Endocrinol Metab 295:356-67. | Mouse | |
| Cohen 2008 Am J Clin Nutr | 2008 | Cohen DA, Sturm R (2008) Body mass index is increasing faster among taller persons. Am J Clin Nutr 87:445-8. | Human | |
| Kraegen 2008 Proc Natl Acad Sci U S A | 2008 | Kraegen EW, Cooney GJ, Turner N (2008) Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction. Proc Natl Acad Sci U S A 105:7627-8. https://doi.org/10.1073/pnas.0803901105 | ||
| Barquera 2007 Int J Obes (Lond) | 2007 | Barquera S, Peterson KE, Must A, Rogers BL, Flores M, Houser R, Monterrubio E, Rivera-Dommarco JA (2007) Coexistence of maternal central adiposity and child stunting in Mexico. Int J Obes (Lond) 31:601-7. | Human | |
| Joshi 2007 JAMA | 2007 | Joshi P, Islam S, Pais P, Reddy S, Dorairaj P, Kazmi K, Pandey MR, Haque S, Mendis S, Rangarajan S, Yusuf S (2007) Risk factors for early myocardial infarction in South Asians compared with individuals in other countries. JAMA 297:286-94. | Human | |
| Brien 2007 Can J Public Health | 2007 | Brien SE, Katzmarzyk PT, Craig CL, Gauvin L (2007) Physical activity, cardiorespiratory fitness and body mass index as predictors of substantial weight gain and obesity: the Canadian physical activity longitudinal study. Can J Public Health 98:121-4.. | Human | |
| Heymsfield 2007 Am J Clin Nutr | 2007 | Heymsfield SB, Gallagher D, Mayer L, Beetsch J, Pietrobelli A (2007) Scaling of human body composition to stature: new insights into body mass index. Am J Clin Nutr 86:82-91. | Human | Skeletal muscle Nervous system Liver Fat |
| De Onis 2007 Bull World Health Organization | 2007 | de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J (2007) Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organization 85:660-7. | Human | |
| Wells 2007 Biol Rev Camb Philos Soc | 2007 | Wells JC (2007) The thrifty phenotype as an adaptive maternal effect. Biol Rev Camb Philos Soc 82:143-72. | Human | |
| Haslam 2007 Obes Rev | 2007 | Haslam D (2007) Obesity: a medical history. Obes Rev 8 Suppl 1:31-6. | Human | |
| Boushel 2007 Diabetologia | 2007 | Boushel RC, Gnaiger E, Schjerling P, Skovbro M, Kraunsoee R, Dela F (2007) Patients with Type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 50:790-6. | Human | Skeletal muscle |
| Wells 2006 Biol Rev Camb Philos Soc | 2006 | Wells JC (2006) The evolution of human fatness and susceptibility to obesity: an ethological approach. Biol Rev Camb Philos Soc 81:183-205. | Human | |
| WHO 2006 Geneva: World Health Organization | 2006 | WHO Multicentre Growth Reference Study Group (2006) WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: Methods and development. Geneva: World Health Organization 312 pp. | Human | |
| WHO Expert Consultation 2004 Lancet | 2004 | WHO Expert Consultation (2004) Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363:157-63. | Human | |
| Chen 2002 Obes Rev | 2002 | Chen W, Lin CC, Peng CT, Li CI, Wu HC, Chiang J, Wu JY, Huang PC (2002) Approaching healthy body mass index norms for children and adolescents from health-related physical fitness. Obes Rev 3:225-32. | Human | |
| Colin 2002 Am J Epidemiol | 2002 | Colin Bell A, Adair LS, Popkin BM (2002) Ethnic differences in the association between body mass index and hypertension. Am J Epidemiol 155:346-53. | Human | |
| Jørgensen 2002 Diabetes Care | 2002 | Jørgensen ME, Bjeregaard P, Borch-Johnsen K (2002) Diabetes and impaired glucose tolerance among the inuit population of Greenland. Diabetes Care 25: 1766-1771. | Human | |
| Deurenberg 2001 Eur J Clin Nutr | 2001 | Deurenberg P, Andreoli A, Borg P, Kukkonen-Harjula K, de Lorenzo A, van Marken Lichtenbelt WD, Testolin G, Vigano R, Vollaard N (2001) The validity of predicted body fat percentage from body mass index and from impedance in samples of five European populations. Eur J Clin Nutr 55:973-9. | Human | Fat |
| Gallagher 2000 Am J Clin Nutr | 2000 | Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y (2000) Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr 72:694-701. | Human | Fat |
| Cole 2000 BMJ | 2000 | Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320:1240-3. | Human | |
| WHO 2000 Sydney Health Comm AU | 2000 | WHO Regional Office for the Western Pacific (2000) The Asia-Pacific perspective: redefining obesity and its treatment. World Health Organization Western Pacific Region 55 pp. | Human | |
| Wei 1999 JAMA | 1999 | Wei M, Kampert JB, Barlow CE, Nichaman MZ, Gibbons LW, Paffenbarger RS Jr, Blair SN (1999) Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA 282:1547-53. | Human | |
| Neel 1962 Am J Hum Genet | 1962 | Neel JV (1962) Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 14:353-62. | Human |
Sort in ascending/descending order by a click on one of the small symbols in squares below.
| Year | Reference | Organism | Tissue;cell | |
|---|---|---|---|---|
| Dantas 2024 Abstract IOC163 | 2024 | Dantas WS, Heintz EC, Zunica ERM, Dousay M, Davuluri G, Yu CS, Murphy MP, Axelrod CL, Kirwan JP (2024) Mito-Q supplementation reverses sarcopenic obesity in aged mice by restoring mitochondrial function and enhancing antioxidant response. Mitochondr Physiol Network 28.11. | Mouse | |
| Gama Perez 2023 MiP2023 | 2023 |  | Fat | |
| Roden 2023 MiP2023 | 2023 |  | Human | Liver Fat |
| Alan 2023 MiP2023 | 2023 |  | Mouse | |
| Garcia-Roves 2023 MiP2023 | 2023 |  | Human | Fat |
| Timon-Gomez 2023 MiP2023 | 2023 |  | ||
| Axelrod 2023 MiP2023 | 2023 |  | Human | Skeletal muscle |
| Sobotka 2023 MiP2023 | 2023 |  | Human | |
| Valencia 2023 MiP2023 | 2023 |  | Human | Blood cells |
| Owesny 2023 MiP2023 | 2023 |  | Mouse | Heart |
| Chicco 2023 MiP2023 | 2023 |  | Mouse | |
| Gnaiger 2023 MiP2023 | 2023 |  | Human | Skeletal muscle |
| Kayser 2023 MiP2023 | 2023 |  | ||
| Gnaiger 2020 APS Chicago | 2020 | Gnaiger E (2020) Aerobic exercise capacity and mitochondrial fitness: from muscle to brain. APS2020 Chicago. | ||
| Axelrod 2019 Abstract IOC141 | 2019 | Axelrod CL, Davuluri G, Zunica ERM, Noland RC, Hoppel CL, Kirwan JP (2019) Administration of BAM15 to obese C57BL/6J mice increases skeletal muscle fatty acid oxidation independent of OXPHOS or ETC capacity. Mitochondr Physiol Network 24.02. | Mouse | Skeletal muscle |
| Dominguez-Amorocho 2019 MiP2019 | 2019 | | Mouse | Lymphocyte |
| Gnaiger 2019 MiP2019 | 2019 | | Human | Skeletal muscle |
| Garcia-Roves 2019 MiP2019 | 2019 | | Mouse | |
| Storder 2018 MiPschool Tromso E2 | 2018 |  | Mouse | Fat |
| Boardman 2018 MiPschool Tromso D3 | 2018 | | Mouse | Heart |
| MartinsAD 2018 MiPschool Tromso E2 | 2018 | | Human | Genital |
| Garcia-Roves 2018 MiP2018a | 2018 | | Mouse | |
| Greyslak 2018 FASEB J | 2018 | Greyslak KT, Hetrick B, Takahashi DL, Dean T, Kievit P, Sullivan EL, McCurdy CE (2018) Exposure to a western-style diet during early development reduces skeletal muscle lipid metabolism and CI-dependent oxidative capacity in juvenile non-human primate offspring. FASEB J. | Other mammals | Skeletal muscle |
| Arnould 2018 MiP2018b | 2018 | | Mouse | Fat Fibroblast |
| Stankova 2018 MiP2018 | 2018 |  | Mouse | Liver |
| Aasum 2017 Abstract MITOEAGLE Barcelona | 2017 |  | Mouse | Heart |
| Peral 2017 Abstract MITOEAGLE Barcelona | 2017 | | Human | Fat |
| Soares 2017 MiPschool Obergurgl | 2017 |  | Human | |
| Distefano 2017 MiPschool Obergurgl | 2017 |  | Human | Skeletal muscle |
| Lee 2017 MiPschool Obergurgl | 2017 |  | Human | |
| Moreira 2017 MiP2017 | 2017 |  | Human | Genital |
| Keppner 2017 MiP2017 | 2017 | | Human | Blood cells |
| Periasamy 2017 MiP2017 | 2017 | | Mouse | |
| Coen 2017 MiP2017 B1 | 2017 |  | ||
| Liu 2017 MiP2017 | 2017 |  | ||
| Jansen 2017 MiP2017 | 2017 | | Mouse | |
| Sobotka 2017 Abstract MITOEAGLE Barcelona | 2017 | | Rat | Liver |
| Claret 2017 Abstract MITOEAGLE Barcelona | 2017 | | ||
| Shabalina 2017 Abstract MITOEAGLE Barcelona | 2017 | | Mouse | Fat |
| Fromme 2017 Abstract MITOEAGLE Barcelona | 2017 | | Mouse | Fat |
| Sanchez-Feutrie 2017 Abstract MITOEAGLE Barcelona | 2017 | | Mouse | Fat |
| Sobotka 2016 Abstract IOC116 | 2016 | Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11 | Rat | Liver |
| Garcia-Roves 2016a Abstract MitoFit Science Camp 2016 | 2016 | Design and implementation of systems biology approaches to integrate heterogenic data in biomedical research. | ||
| Madlala 2015 Abstract MiPschool Cape Town 2015 | 2015 | Fructose-induced ROS production: The role of uric acid and transforming growth factor (TGF)-β1. | Human | Liver Other cell lines |
| Esterhuizen 2015 Abstract MiPschool Cape Town 2015 | 2015 | Metabolomics reveal altered mitochondrial metabolism associated with hypertension in a black South African male cohort: the SABPA study. | Human | |
| Cortright 2015 Abstract MiPschool Greenville 2015 | 2015 | Intramyocellular triacylglycerol is associated with peroxisomal biogenesis in skeletal muscle from lean and obese humans. | Human | Skeletal muscle |
| Tyrrell 2015 Abstract MiPschool Greenville 2015 | 2015 | Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. | Human | Blood cells |
| Funk 2015 Abstract MiPschool Greenville 2015 | 2015 | Isolated mitochondria from liver and brain of long-lived growth hormone receptor gene disrupted mice demonstrate reduced respiration rates. | Mouse | Nervous system Liver |
| Huang 2015 Abstract MiPschool Greenville 2015 | 2015 | Intramyocellular triacylglycerol is associated with peroxisomal biogenesis in skeletal muscle from lean and obese humans. | Human | Skeletal muscle |
| Huettemann 2015 Abstract MiP2015 | 2015 | Regulation of mitochondrial respiration and apoptosis by cytochrome c phosphorylation. | Kidney | |
| Lindquist 2015 Abstract IOC106 | 2015 | Alteraas EK, Lindquist C, Berge RK, Bjorndal B (2015) OXPHOS capacity in mouse liver altered by modified fatty acids that inhibit or stimulate beta-oxidation. Mitochondr Physiol Network 20.10. | Mouse | Liver |
| Pecinova 2015 Abstract MiP2015 | 2015 | Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue. | Rat | Fat |
| Holloway 2014 Abstract MiP2014 | 2014 | Acute diet-induced insulin resistance is associated with increased adipose tissue mitochondrial ROS emissions. | Mouse | Fat |
| Andersen 2014 Abstract IOC 2014-04 Schroecken | 2014 | Andersen M, Vienberg SG, Novod JB, Brandauer J, Holst B, Treebak JT (2014) Nicotinamide phosphoribosyltransferase knockdown impairs mitochondrial function in mouse myoblasts. Mitochondr Physiol Network 19.02. | Mouse | Skeletal muscle Other cell lines |
| Alberici 2014 Abstract MiP2014 | 2014 | Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism. | Rat | Skeletal muscle |
| Bresciani Martins de Andrade 2014 Abstract MiP2014 | 2014 | Mitochondrial function in white adipose tissue: palmitoleic acid (C16:1n7) treatment enhances white adipocyte oxygen consumption. | Fat | |
| Shirihai 2014 Abstract MiP2014 | 2014 | Mitochondrial dynamics and quality control, a conflict of interest. | Human | Fat |
| Zorzano 2014 Abstract MiP2014 | 2014 | Metabolic implications of mitofusin 2 dysfunction. | Mouse | Skeletal muscle |
| Ojuka 2014 Abstract IOC96 | 2014 | Ojuka E (2014) Excess fructose consumption: effects on mitochondrial function and insulin resistance. Mitochondr Physiol Network 19.11. | Human | |
| Larsen 2014 Abstract MiP2014 | 2014 | The effect of high intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. | Human | Skeletal muscle Fat |
| Lai 2014 Abstract2 MiP2014 | 2014 | Bioenergetic differences between permeabilized red and white fibers of a non-obese model of type II diabetes. | Rat | Skeletal muscle |
| Iyer 2014 Abstract MiP2014 | 2014 | Bioenergetics: arts meets gentle science in sickness and in health. | Human | |
| DeLany 2013 TOS | 2013 | Skeletal muscle mitochondrial respiration is lower in African American compared to Caucasian women and is associated with resting metabolic rate and cardiorespiratory fitness. | Human | Skeletal muscle |
| Holloway 2013 Abstract MiP2013 | 2013 | Holloway GP (2013) Tissue specific changes in respiratory substrate kinetics in the ZDF rat and in response to resveratrol supplementation. Mitochondr Physiol Network 18.08. | Rat | Heart Skeletal muscle |
| Cavalcanti de Albuquerque 2013 Abstract MiP2013 | 2013 | Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08. | Rat | Skeletal muscle |
| Shabalina 2013 Abstract MiP2013 | 2013 | Shabalina IG, Petrovic N, Kalinovich AV, Cannon B, Nedergaard J (2013) Comparative study of brown and white adipose tissue mitochondria in mice upon cold acclimation. Mitochondr Physiol Network 18.08. | Fat | |
| Oliveira HC 2013 Abstract MiP2013 | 2013 | Oliveira HC, Dorighello GG, Rovani JC, Raposo HF, Paim BA, Vercesi AE (2013) Intermittent fasting improves oxidative stress but not metabolic disturbances and atherosclerosis in hypercholesterolemic mice. Mitochondr Physiol Network 18.08. | Mouse | Liver |
| Kotwica 2013 Abstract MiP2013 | 2013 | Kotwica AO, Horscroft JA, Murray AJ(2013) Mitochondrial respiration in heart and soleus of ob/ob mice. Mitochondr Physiol Network 18.08. | Mouse | Heart Skeletal muscle |
| Garcia-Roves 2013 Abstract MiP2013 | 2013 | Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08. | Mouse | Skeletal muscle Nervous system Liver Islet cell;pancreas;thymus Fat |
| Irving 2013 Abstract MiP2013 | 2013 | Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08. | Mouse | Skeletal muscle Liver Fat |
| Camacho-Pereira 2013 Abstract IOC75 | 2013 | Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03. | Mouse | Liver HEK Macrophage-derived |
| Irving 2012 Abstract IOC72 | 2012 | Irving BA (2012) AgRP deficient female mice have elevated body weight and hypothalamic mitochondrial oxidative capacity. Mitochondr Physiol Network 17.13. | Mouse Rat | Skeletal muscle Nervous system Liver Fat |
| Distefano 2012 Abstract IOC68 | 2012 | Distefano G, Dube JJ, Helbling NL, Ritov VB, Stefanovic-Racic M, Toledo FGS, Ng J, Goodpaster BH, Coen PM (2012) Human skeletal muscle mitochondria respiration: The influence of aging, adiposity and aerobic fitness. MiPNet17.08. | Human | Skeletal muscle |
| Gnaiger 2011 Abstract-Berlin | 2011 | Gnaiger E (2011) Fewer mitochondria - mitochondrial 'fever': Mitochondrial physiology and capacity of oxidative phosphorylation in active and sedentary life styles. Abstract Targeting Mitochondria Berlin. | Human | |
| Pesta 2011Abstract Mitochondrial Medicine-Training | 2011 | Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago. | Human | Skeletal muscle |
| Pesta 2010 MiP Abstract | 2010 | Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010. | Human |
Publications: BME and body fat
| Reference | |
|---|---|
| Bosy-Westphal 2009 Br J Nutr | Bosy-Westphal A, Plachta-Danielzik S, Dörhöfer RP, Müller MJ (2009) Short stature and obesity: positive association in adults but inverse association in children and adolescents. Br J Nutr 102:453-61. |
| Chambers 2020 J Appl Physiol (1985) | Chambers TL, Burnett TR, Raue U, Lee GA, Finch WH, Graham BM, Trappe TA, Trappe S (2020) Skeletal muscle size, function, and adiposity with lifelong aerobic exercise. J Appl Physiol (1985) 128:368–78. |
| Deurenberg 2001 Eur J Clin Nutr | Deurenberg P, Andreoli A, Borg P, Kukkonen-Harjula K, de Lorenzo A, van Marken Lichtenbelt WD, Testolin G, Vigano R, Vollaard N (2001) The validity of predicted body fat percentage from body mass index and from impedance in samples of five European populations. Eur J Clin Nutr 55:973-9. |
| Gallagher 2000 Am J Clin Nutr | Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y (2000) Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr 72:694-701. |
| Meeuwsen 2010 Clin Nutr | Meeuwsen S, Horgan GW, Elia M (2010) The relationship between BMI and percent body fat, measured by bioelectrical impedance, in a large adult sample is curvilinear and influenced by age and sex. Clin Nutr 29:560-6. |
| Mialich 2014 Nutr Hosp | Mialich MS, Martinez EZ, Jordao JJ (2014) Application of body mass index adjusted for fat mass (BMIfat) obtained by bioelectrical impedance in adults. Nutr Hosp 30:417-24. |
| Mialich 2018 J Electr Bioimp | Mialich MS, Silva BR, Jordao AA (2018) Cutoff points of BMI for classification of nutritional status using bioelectrical impedance analysis. J Electr Bioimp 9:24-30. |
| Misra 2019 J Postgrad Med | Misra P, Singh AK, Archana S, Lohiya A, Kant S (2019) Relationship between body mass index and percentage of body fat, estimated by bio-electrical impedance among adult females in a rural community of North India: A cross-sectional study. J Postgrad Med 65:134-40. |
| National Academies of Sciences, Engineering, and Medicine 2023 BMI and beyond | National Academies of Sciences, Engineering, and Medicine (2023) BMI and beyond: Considering context in measuring obesity and its applications: Proceedings of a workshop—in brief. The National Academies Press, Washington, DC. https://doi.org/10.17226/27185 |
| National Academies of Sciences, Engineering, and Medicine 2024 Body composition and obesity | National Academies of Sciences, Engineering, and Medicine (2024) Exploring the science on measures of body composition, body fat distribution, and obesity. National Academies Press, Washington, DC https://doi.org/10.17226/27461. |
| Romero-Corral 2008 Int J Obes (Lond) | Romero-Corral A, Somers VK, Sierra-Johnson J, Thomas RJ, Collazo-Clavell ML, Korinek J, Allison TG, Batsis JA, Sert-Kuniyoshi FH, Lopez-Jimenez F (2008) Accuracy of body mass index in diagnosing obesity in the adult general population. Int J Obes (Lond) 32:959-66. |
| Wollner 2017 J Public Health Res | Wollner M, Paulo Roberto BB, Alysson Roncally SC, Jurandir N, Edil LS (2017) Accuracy of the WHO's body mass index cut-off points to measure gender- and age-specific obesity in middle-aged adults living in the city of Rio de Janeiro, Brazil. J Public Health Res 6:904. |
MitoPedia: BME and mitObesity
» Body mass excess and mitObesity | BME and mitObesity news | Summary |
| Term | Abbreviation | Description |
|---|---|---|
| BME cutoff points | BME cutoff | Obesity is defined as a disease associated with an excess of body fat with respect to a healthy reference condition. Cutoff points for body mass excess, BME cutoff points, define the critical values for underweight (-0.1 and -0.2), overweight (0.2), and various degrees of obesity (0.4, 0.6, 0.8, and above). BME cutoffs are calibrated by crossover-points of BME with established BMI cutoffs. |
| Body fat excess | BFE | In the healthy reference population (HRP), there is zero body fat excess, BFE, and the fraction of excess body fat in the HRP is expressed - by definition - relative to the reference body mass, M°, at any given height. Importantly, body fat excess, BFE, and body mass excess, BME, are linearly related, which is not the case for the body mass index, BMI. |
| Body mass | m [kg]; M [kg·x-1] | The body mass M is the mass (kilogram [kg]) of an individual (object) [x] and is expressed in units [kg/x]. Whereas the body weight changes as a function of gravitational force (you are weightless at zero gravity; your floating weight in water is different from your weight in air), your mass is independent of gravitational force, and it is the same in air and water. |
| Body mass excess | BME | The body mass excess, BME, is an index of obesity and as such BME is a lifestyle metric. The BME is a measure of the extent to which your actual body mass, M [kg/x], deviates from M° [kg/x], which is the reference body mass [kg] per individual [x] without excess body fat in the healthy reference population, HRP. A balanced BME is BME° = 0.0 with a band width of -0.1 towards underweight and +0.2 towards overweight. The BME is linearly related to the body fat excess. |
| Body mass index | BMI | The body mass index, BMI, is the ratio of body mass to height squared (BMI=M·H-2), recommended by the WHO as a general indicator of underweight (BMI<18.5 kg·m-2), overweight (BMI>25 kg·m-2) and obesity (BMI>30 kg·m-2). Keys et al (1972; see 2014) emphasized that 'the prime criterion must be the relative independence of the index from height'. It is exactly the dependence of the BMI on height - from children to adults, women to men, Caucasians to Asians -, which requires adjustments of BMI-cutoff points. This deficiency is resolved by the body mass excess relative to the healthy reference population. |
| Comorbidity | Comorbidities are common in obesogenic lifestyle-induced early aging. These are preventable, non-communicable diseases with strong associations to obesity. In many studies, cause and effect in the sequence of onset of comorbidities remain elusive. Chronic degenerative diseases are commonly obesity-induced. The search for the link between obesity and the etiology of diverse preventable diseases lead to the hypothesis, that mitochondrial dysfunction is the common mechanism, summarized in the term 'mitObesity'. | |
| Healthy reference population | HRP | A healthy reference population, HRP, establishes the baseline for the relation between body mass and height in healthy people of zero underweight or overweight, providing a reference for evaluation of deviations towards underweight or overweight and obesity. The WHO Child Growth Standards (WHO-CGS) on height and body mass refer to healthy girls and boys from Brazil, Ghana, India, Norway, Oman and the USA. The Committee on Biological Handbooks compiled data on height and body mass of healthy males from infancy to old age (USA), published before emergence of the fast-food and soft-drink epidemic. Four allometric phases are distinguished with distinct allometric exponents. At heights above 1.26 m/x the allometric exponent is 2.9, equal in women and men, and significantly different from the exponent of 2.0 implicated in the body mass index, BMI [kg/m2]. |
| Height of humans | h [m]; H [m·x-1] | The height of humans, h, is given in SI units in meters [m]. Humans are countable objects, and the symbol and unit of the number of objects is N [x]. The average height of N objects is, H = h/N [m/x], where h is the heights of all N objects measured on top of each other. Therefore, the height per human has the unit [m·x-1] (compare body mass [kg·x-1]). Without further identifyer, H is considered as the standing height of a human, measured without shoes, hair ornaments and heavy outer garments. |
| Length | l [m] | Length l is an SI base quantity with SI base unit meter m. Quantities derived from length are area A [m2] and volume V [m3]. Length is an extensive quantity, increasing additively with the number of objects. The term 'height' h is used for length in cases of vertical position (see height of humans). Length of height per object, LUX [m·x-1] is length per unit-entity UX, in contrast to lentgth of a system, which may contain one or many entities, such as the length of a pipeline assembled from a number NX of individual pipes. Length is a quantity linked to direct sensory, practical experience, as reflected in terms related to length: long/short (height: tall/small). Terms such as 'long/short distance' are then used by analogy in the context of the more abstract quantity time (long/short duration). |
| MitObesity drugs | Bioactive mitObesity compounds are drugs and nutraceuticals with more or less reproducible beneficial effects in the treatment of diverse preventable degenerative diseases implicated in comorbidities linked to obesity, characterized by common mechanisms of action targeting mitochondria. | |
| Obesity | Obesity is a disease resulting from excessive accumulation of body fat. In common obesity (non-syndromic obesity) excessive body fat is due to an obesogenic lifestyle with lack of physical exercise ('couch') and caloric surplus of food consumption ('potato'), causing several comorbidities which are characterized as preventable non-communicable diseases. Persistent body fat excess associated with deficits of physical activity induces a weight-lifting effect on increasing muscle mass with decreasing mitochondrial capacity. Body fat excess, therefore, correlates with body mass excess up to a critical stage of obesogenic lifestyle-induced sarcopenia, when loss of muscle mass results in further deterioration of physical performance particularly at older age. | |
| VO2max | VO2max; VO2max/M | Maximum oxygen consumption, VO2max, is and index of cardiorespiratory fitness, measured by spiroergometry on human and animal organisms capable of controlled physical exercise performance on a treadmill or cycle ergometer. VO2max is the maximum respiration of an organism, expressed as the volume of O2 at STPD consumed per unit of time per individual object [mL.min-1.x-1]. If normalized per body mass of the individual object, M [kg.x-1], mass specific maximum oxygen consumption, VO2max/M, is expressed in units [mL.min-1.kg-1]. |
MitoPedia concepts:
MiP concept
Labels:
MitoPedia:BME
