NS e-input

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Bioblasts - Richard Altmann and MiPArt by Odra Noel
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NS e-input


NS e-input or the NS-pathway control state is electron input from a combination of substrates for the N-pathway control state and S-pathway control state through Complexes CI and CII simultaneously into the Q-junction. NS e-input corresponds to TCA cycle function in vivo, with convergent electron flow through the Electron transfer pathway. In mt-preparations, NS e-input requires addition not only of NADH- (N-) linked substrates (pyruvate&malate or glutamate&malate), but of succinate (S) simultaneously, since metabolite depletion in the absence of succinate prevents a significant stimulation of S-linked respiration. For more details, see: Additive effect of convergent electron flow.

Abbreviation: NS, CI&II

Reference: Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol

MitoPedia concepts: MiP concept, SUIT concept 

From CI&II e-input to NS e-input

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