Mitochondria (Greek mitos: thread; chondros: granule) are small structures within cells, which function in cell respiration as powerhouses or batteries. Mitochondria belong to the bioblasts of Richard Altmann. Abbreviation: mt, as generally used in mtDNA. Singular: mitochondrion (bioblast); plural: mitochondria (bioblasts).
- Gnaiger et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v3. - »MitoFit Preprint Arch«
Mitochondria are the electric engines in our cells - and research with the Oroboros O2k
- Mitochondria burn the calories of food and convert them into useful work. How fast do our mitochondrial engines run? With the world-wide successful Oroboros O2k instrument, scientists measure oxygen consumption or cell respiration. With oxygen sensors the O2k addresses the question of rate: how fast does the engine run?
- The NextGen-O2k combines measurement of O2 flux (how fast?) with recording of the redox state of Coenzyme Q, which is centre-place at the Q-junction of mitochondrial pathways in core energy metabolism. An integrated new Q-sensor provides information on the state of the engine: how hot does it get (actually: how reduced or oxidized does it get). Our mitochondrial engines may run fast, but they may burn out if they get too hot. The new Q-sensor thus adds diagnostic core information on pathologies, which will make the NextGen-O2k the leading technology for mitochondrial research and medicine. This revolutionary all-in-one device is the next step to conquer mitochondrial disease.
- Among 4,000 people, 1 is a patient affected by mitochondrial disease - a deadly pathology, progressive, little understood, and therefore largely without hope for a cure. Beyond mitochondrial diseases, mitochondria are recognized as key players in disease related to a sedentary lifstyle and aging, such as Alzheimer's. The Oroboros O2k technology supports research to make a difference.
- The field of mitochondrial physiology might gain by aiming at a consensus on the abbreviation for 'mitochondrial'. It is not best practice to use in the same context 'mt' for mtDNA, but 'mi' for miCK (mitochondrial creatine kinase; compare miRNA), and 'm' for mPTP (mitochondrial permeability transition pore). The use of 'mt' in mtDNA seems to be most common and robust, hence the suggestion to use mtCK, etc. --Gnaiger Erich 07:01, 24 April 2012 (CEST)
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