MitoKit-CII

From Bioblast
Jump to: navigation, search

Oroboros Instruments

News         O2k-Products         O2k-Purchase         O2k-Open Support         O2k-Publications         O2k-Workshops and Events         O2k-Network         O2k-Feedback         NextGen-O2k



MitoKit-CII

O2k-Catalogue

Description Cell permeable compound - MitoKit-CII, 2 vials; 1 vial of plasma membrane-permeable succinate-nv (Snv; NV118; 25 mg) and 1 vial of plasma membrane-permeable malonate-nv (Mnanv; NV161; 10 mg).
Product ID 60200-01
Type O2k
Link MitoKit-CII MitoPedia
Image
MITOKIT-CII.jpg



Compounds of MitoKit-CII

The MitoKit-CII consists of the first generation of NeuroVive Pharmaceutical AB's cell permeable succinate and malonate prodrugs. The MitoKit-CII was developed to stimulate (succinate-nv) or inhibit (malonate-nv) the Complex II of the respiratory electron transfer system in living cells, and will expand the toolbox for evaluating the role of mitochondria in disease.
The MitoKit-CII is composed of the following compounds:
Description: Succinate prodrug: C10H14O8, Molecular weight 262.2 g.mol-1
Aliquots of 25 mg


Description: Malonate prodrug: C9H12O8, Molecular weight 248.2 g.mol-1
Aliquots of 10 mg


  • Reference
Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial Complex I deficiency. Nat Commun 7:12317. »Bioblast link« - Original publication introducing Mito-CII.


Expiry date of MitoKit-CII compounds (according to NeuroVive)

Before preparation
  • 3 years in -80° C
  • 1 year in -20° C


Prepared
  • In DMSO solution
  • at room temperature: 24 h
  • at -20 °C: for 6 months


CAS-Numbers
  • MitoKit-CII/Succinate-nv: 1592635-33-0
  • MitoKit-CII/Malonate-nv: 1432752-62-9


Labels: MiParea: Instruments;methods 





HRR: O2k-Protocol 

O2k-chemicals and media