Flavin adenine dinucleotide

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Bioblasts - Richard Altmann and MiPArt by Odra Noel
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Flavin adenine dinucleotide


Flavin adenine dinucleotide, FAD and FADH2, is an oxidation-reduction coenzyme (redox cofactor; compare NADH). FMN and FAD are the prosthetic groups of flavoproteins (flavin dehydrogenases). Type F substrates (fatty acids) generate FADH2, the substrate of electron transferring flavoprotein (CETF). Thus FADH2 forms a junction or funnel of electron transfer to CETF, the F-junction (compare N-junction, Q-junction), in the F-pathway control state. In contrast, FADH2 is not the substrate but the product of succinate dehydrogenase (CII). FAD is the oxidized (quinone) form, which is reduced to FADH2 (hydroquinone form) by accepting two electrons and two protons.

Abbreviation: FAD, FADH2


Yepez 2018 PLOS One Fig1B.jpg
  • A commonly found error requires correction. For clarification, see page 48 in Gnaiger (2020)

MitoPedia topics: Substrate and metabolite