Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Caito 2015 Antioxid Redox Signal

From Bioblast
Publications in the MiPMap
Caito SW, Aschner M (2015) Mitochondrial redox dysfunction and environmental exposures. Antioxid Redox Signal 23:578-95.

Β» PMID:25826672

Caito SW, Aschner M (2015) Antioxid Redox Signal

Abstract: Mitochondria are structurally and biochemically diverse, even within a single type of cell. Protein complexes localized to the inner mitochondrial membrane synthesize ATP by coupling electron transport and oxidative phosphorylation. The organelles produce reactive oxygen species (ROS) from mitochondrial oxygen and ROS can, in turn, alter the function and expression of proteins used for aerobic respiration by post-translational and transcriptional regulation. Recent Advances: New interest is emerging not only into the roles of mitochondria in disease development and progression but also as a target for environmental toxicants.

Dysregulation of respiration has been linked to cell death and is a major contributor to acute neuronal trauma, peripheral diseases, as well as chronic neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.

Here, we discuss the mechanisms underlying the sensitivity of the mitochondrial respiratory complexes to redox modulation, as well as examine the effects of environmental contaminants that have well-characterized mitochondrial toxicity. The contaminants discussed in this review are some of the most prevalent and potent environmental contaminants that have been linked to neurological dysfunction, altered cellular respiration, and oxidation.


Labels: MiParea: Respiration, mt-Membrane, Comparative MiP;environmental MiP, mt-Medicine, Patients, Pharmacology;toxicology  Pathology: COPD  Stress:Cell death, Ischemia-reperfusion, Oxidative stress;RONS  Organism: Human, Mouse, Rat, Bovines, Drosophila, Fishes, Hexapods  Tissue;cell: Heart, Nervous system, Liver, Kidney, Lung;gill, Endothelial;epithelial;mesothelial cell  Preparation: Isolated mitochondria  Enzyme: Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase  Regulation: Calcium, Redox state  Coupling state: OXPHOS  Pathway: N, S, CIV 


Review