Harmonization: Difference between revisions

Latest revision as of 14:27, 19 October 2022

high-resolution terminology - matching measurements at high-resolution

Harmonization

Description

Harmonization is the process of minimizing redundant or conflicting standards which may have evolved independently. To obtain a common basis in reaching a defined objective, critical requirements are identified that need to be retained.

Harmonization of some terms in mitochondrial physiology links separate 'subcultures' in publication. Ambiguities are pointed out for clarification of concepts. A platform-independent terminology is preferred. See also Table 2. Harmonization of terminology on respiratory states^[1].

Table 1. Some platform-independent and platform-specific or outdated terms in mitochondrial physiology


Symbol	Platform-independent terms	Platform-specific or outdated terms
ce	living cells	intact cells
R	ROUTINE respiration, in ROUTINE state	basal respiration, in basal state
P	OXPHOS capacity, in OXPHOS state of mt-preparations	State 3
L	LEAK respiration	proton leak; State 4
E	ET capacity, electron transfer capacity	maximum respiration; State 3u
L/E	L/E coupling-control ratio	1/UCR = L/E (ambiguous)
L/P	L/P coupling-control ratio	1/RCR = L/P
R/E	R/E control ratio	1/UCR = E/R
R-L	R-L net ROUTINE capacity, net ROUTINE respiration	ATP production, ATP-linked respiration
E-R	E-R reserve capacity	spare capacity
Rox	residual oxygen consumption, in ROX state	nonmitochondrial respiration; State 2

MitoPedia O2k and high-resolution respirometry: Oroboros QM

↑ Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496. https://doi.org/10.1371/journal.pone.0264496

[1] Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496. https://doi.org/10.1371/journal.pone.0264496

[1]

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 {{MitoPedia
-|description='''Harmonization''' is the process of minimizing redundant or conflicting [[standard]]s which may have evolved independently.
+|description='''Harmonization''' is the process of minimizing redundant or conflicting [[standard]]s which may have evolved independently. To obtain a common basis in reaching a defined objective, critical [[requirement]]s are identified that need to be retained.
-|info=https://en.wikipedia.org/wiki/Harmonization
 }}
-{{MitoPedia concepts
-|mitopedia concept=MitoFit Quality Control System
+:::: Harmonization of some terms in mitochondrial physiology links separate 'subcultures' in publication. Ambiguities are pointed out for clarification of concepts. A platform-independent terminology is preferred. See also '''Table 2. Harmonization of terminology on respiratory states'''<ref>Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496. https://doi.org/10.1371/journal.pone.0264496</ref>.
+::::: <span style="background:#eaecf0">'''Table 1. Some platform-independent and platform-specific or outdated terms in mitochondrial physiology
+::::: {| class="wikitable"
+|+
+|-
+! Symbol !! Platform-independent terms !! Platform-specific or outdated terms
+|-
+| ce || [[living cells]] || intact cells
+|-
+| ''R'' || [[ROUTINE respiration]], in ROUTINE state || [[basal respiration]], in basal state
+|-
+| ''P'' || [[OXPHOS capacity]], in OXPHOS state of mt-preparations || [[State 3]]
+|-
+| ''L'' || [[LEAK respiration]] || [[proton leak]]; [[State 4]]
+|-
+| ''E'' || [[ET capacity]], electron transfer capacity || maximum respiration; State 3u
+|-
+| ''L/E'' || [[L/E coupling-control ratio |''L/E'' coupling-control ratio]] || 1/UCR = ''L/E'' (ambiguous)
+|-
+| ''L/P'' || [[L/P coupling-control ratio |''L/P'' coupling-control ratio]] || 1/[[RCR]] = ''L/P''
+|-
+| ''R/E'' || [[R/E control ratio |''R/E'' control ratio]] || 1/[[UCR]] = ''E/R''
+|-
+| ''R-L'' || [[R-L net ROUTINE capacity |''R-L'' net ROUTINE capacity]], net ROUTINE respiration || ATP production, ATP-linked respiration
+|-
+| ''E-R'' || [[E-R reserve capacity |''E-R'' reserve capacity]] || spare capacity
+|-
+| ''Rox'' || [[residual oxygen consumption]], in ROX state || nonmitochondrial respiration; [[State 2]]
+|}
+{{MitoPedia O2k and high-resolution respirometry
+|mitopedia O2k and high-resolution respirometry=Oroboros QM
 }}
-{{MitoPedia methods}}
-{{MitoPedia O2k and high-resolution respirometry}}
-{{MitoPedia topics}}
-The goal of '''harmonization''' is to find commonalities, identify critical requirements that need to be retained, and provide a common basis. For businesses, harmonization cuts costs and simplifies the process of meeting [[requirement]]s. It also reduces complexity for those tasked with testing and auditing standards compliance.
-Author: [[User:Weber Benno|Weber Benno]] 08:52, 10 February 2016 (CET)