Gnaiger 1994 BTK

Gnaiger E, Gellerich FN, Wyss M (1994) What is Controlling Life? 50 years after Erwin Schrödinger's What is Life? Modern Trends in BiothermoKinetics 3, Innsbruck Univ Press, 336 pp.

» Open Access-BTK 1994

Gnaiger E, Gellerich FN, Wyss M (1994) Innsbruck Univ Press

Abstract: Erwin Schrödinger's 'What is Life?' is one of the most influential books of the last century in the biological sciences. It continues to provoke discussions and stimulate interdisciplinary developments in biophysics. Starting with reflections on Schrödinger's famous account of negative entropy in living systems, an international group of scientists presents the latest advancements on the dynamics and control of metabolic processes. This volume of Modern Trends in BioThermoKinetics develops for the first time the explicit link between thermodynamics, metabolic control, bioenergetics and clinical applications.

• O2k-Network Lab: AT_Innsbruck_Gnaiger E

Labels: MiParea: Respiration, mt-Awareness 

Coupling state: OXPHOS 

HRR: Oxygraph-2k, Theory 

CONTENTS: Full Papers

• OROBOROS Oxygraph applications

Preface

• Margreiter R, Innsbruck. p 13.
• Trends in Bioenergetics. An Introduction. Gnaiger E, Gellerich FN, Innsbruck. p 14.
• "German Ideology" as seen by Erwin Schrödinger in Letters to Hans Thirring. From Their Correspondence (1946-1949). Oberkofler G, Goller P. Innsbruck. p 19.

Part 1. What is Negative Entropy? From World Views to Bioenergetics

• Erwin Schrödinger's World View. The Role of Physics and Biology in his Philosophical System. Götschl J. Graz. p 23.
• Science, Art and Revelation. Wagensberg J. Barcelona. p 32.
• Negentropy and Historical Arrow of Time - Thermodynamical and Informational Aspects of the Darwinian Revolution. Azzone GF. Padova. p 38.
• Negative Entropy: Another Approach. Lantos CP. Buenos Aires. p 45.
• Schrödinger's What is Life?: The Biophysical Legacy 50 Years Later. Welch GR. New Orleans. p 48.
• What is Schrödinger's Negentropy? Ho MW. London. p 50.
• Negative Entropy for Living Systems. Controversy between Nobel Laureates Schrödinger, Pauling and Perutz. Gnaiger E. Innsbruck. p 62.
• A Paradigm for Energy Balance in Muscle Function. Kushmerick MJ. Seattle. p 71.
• A Controlled Chaotic Attractor Controls Life. Lloyd D. Cardiff. p 77.
• Disease as Instability, Error and Entropy. Azzone GF. Padova. p 81.

Part 2. Control and Regulation: Theory, Models, and Experi­ment

• The Macro- and Microworld of Control Theory. Kholodenko BN, Westerhoff HV, Cascante M. Moscow, Amsterdam. Barcelona. p 88.
• How Should we Quantify Metabolic Regulation? Hofmeyr JHS, Cornish-Bowden A. Stellenbosch, Marseille. p 91.
• Control and Regulation: The Best of Both Worlds. Westerhoff HV, Jensen PR, Rohwer JM, Kholo­denko BN. Amsterdam, Lyngby, Moscow. p 95.
• Evolutionary Optimization of Enzymes on the Basis of Kinetic and Thermodynamic Principles. Heinrich R, Klipp E, Stephani A, Wilhelm T. Berlin. p 99.
• Detecting Elementary Modes of Functioning in Metabolic Networks. Schuster S, Hilgetag C, Fell DA. Berlin, Oxford. p 103.

Part 3. Coupling and Mechanisms in the Regulation of Electron, ATP and Ion Fluxes

• Leaks and Slips during Mitochondrial Electron Trans­fer.

S. Luvisetto, M. Canton, I. Schmehl, G.F. Azzone. Padova 122

• Experimental Discrimination between Proton Leak and Redox Slip during Mitochondrial Electron Transport.

M.D. Brand, L.-F. Chien, P.H. Diolez. Cambridge, Bordeaux 125

• Permeability of the Inner Mitochondrial Membrane and Respiration.

M. Canton, S. Luvisetto, I. Schmehl, G.F. Azzone. Padova 129

• The Uncoupling Mechanism of the Anesthetic Bupivacaine.

I. Schmehl, M. Canton, S. Luvisetto, G.F. Azzone. Padova 133

• Influence of the Mechanism of Change in ATP Synthase-ATPase. Stoichiometry on the Control of Oxidative Phosphorylation in situ

X. Leverve, E. Fontaine, P. Espié, C. Keriel, B. Guérin, M. Rigoulet. Grenoble, Bordeaux 137

• ATP Synthesis in Permeabilized Cells: Assessment of the ATP/O Ratios In Situ.

R. Ouhabi, M. Boue-Grabot, J.-P. Mazat. Bordeaux 141

• Permeabilized Spheroplasts as a Tool for Studying the Mechanistic Stoichiometry of Yeast Oxidative Phosphory­la­tion.

V. Fitton, R. Ouhabi, B. Guérin, M. Rigoulet. Bordeaux 145

• Investigations upon the Effect of Monovalent Cations on Oxidative Phosphorylation in Yeast Mitochondria.

S. Manon, X. Roucou, M. Guérin. Bordeaux 150

• Can Mitochondria Sequester Calcium from Physiological Calcium Pulses?

G. Sparagna, K.K. Gunter, S.-S. Sheu, T.E. Gunter. Rochester 154

• Mitochondrial Calcium Spiking: The Physiological Face of Permeability Transition?

F. Ichas, L.S. Jouaville, S.S. Sidash, J.-P. Mazat, E.L. Holmuhamedov. Bordeaux, Pushchino, Kalamazoo 159

• Developmental regulation of Na+,K+- and Ca2+-ATPases in muscle.

M.J. Dauncey, T. Clausen, A.P. Harrison. Cambridge, Århus 163

• What is controlling the cell membrane potential?

J. Siegenbeek van Heukelom et al. Amsterdam, Moscow 169

Part 4. The Microenvironment of Mitochondria and Cells: Diffusion Gradients, Shuttles and Signals

• ADP Diffusion Gradients and Metabolic Oscillatory Signals to Mitochondria in Heart and Liver Cells.

V.A. Saks, E.V. Vasilyeva, Z.A. Khuchua, Y.O. Belikova, M.K. Aliev, T. Kesvatera, T. Tiivel, K. Anflous, R. Ventura-Clapier, Ch. Keriel, E. Fontaine, X. Leverve. Tallinn, Moscow, Paris, Grenoble 178

• Effect of Macromolecules on ADP-Transport into Mitochondria.

F.N. Gellerich, F.D. Laterveer, E. Gnaiger, K. Nicolay. Utrecht, Innsbruck download pdf 181*

• Macromolecules Increase the Channeling of ADP from Mitochondrially Associated Hexokinase to the Mitochondrial Matrix.

F.D. Laterveer, F.N. Gellerich, E. Gnaiger, K. Nicolay. Utrecht, Innsbruck download pdf 186*

• How does Oxygen Pressure Control Oxygen Flux in Isolated Mitochondria? A Methodological Approach by High-Resolution Respirometry and Digital Data Analysis. G. Méndez, E. Gnaiger. Innsbruck, Buenos Aires download pdf 191*

• Determination of Creatine Kinase Fluxes with Purified Creatine Kinase and Isolated Mitochondria using 31P Nuclear Magnetic Resonance.

S. Soboll, A. Conrad, M. Gruwel. Düsseldorf 195

• Oscillations of Intracellular pH or High Energy Phosphate Content Cannot be Detected by Gated NMR during the Cardiac Cycle of an Isovolumic Perfused Rat Heart.

J.A. Hoerter, B. Gillet, P. Mateo, P. Lechene, J.-C. Beloeil. Chatenay Malabry, Gifs/Yvette 199

Part 5. The Impact of Bioenergetics on Cellular, Physiological and Biotechnological Processes

• Chemical Forces in the Cell: Calculations for the ATP System.

E. Gnaiger, M. Wyss. Innsbruck download pdf 207

• The Flow-Force Relation of Oxidative Phosphorylation in Human Forearm Muscle is Sigmoidal.

J.A.L. Jeneson, S.A. Jubrias, M.J. Kushmerick. Utrecht, Seattle 213

• Muscular Contraction, Dissipation and Schrödinger's Negative Entropy.

J. Mejsnar, F. Marsík. Praha 215

• Modelling of Oxidative Phosphorylation in E. coli.

P.R. Jensen, J.M. Rohwer, O. Michelsen, H.V. Westerhoff. Lyngby, Amsterdam 218

• Do Oscillations Control the Bacterial Cell Cycle?

I. Fishov. Beer-Sheva 221

• A Thermochemical Study of the Production of Lactate by Glutaminolysis and Glycolysis in Mouse Macrophage Hybridoma Cells.

R.B. Kemp, S. Hoare, M. Schmalfeldt, C.M.C. Bridge, P.M. Evans, E. Gnaiger. Aberystwyth, Innsbruck. 226

• Catabolic Capacity of Carbon- or Nitrogen-Starved Cultures of Saccharomyces cerevisiae.

C. Larsson, A. Nilsson, L Gustafsson. Göteborg 232

• Energy Allocation and Material Flux in Fish Hepatocytes under Stress. G. Krumschnabel, W. Wieser. Innsbruck 238

• Carbon Flux in Lysine Producing Strain Corynebacterium glutamicum MH20-22B: Analysis by 13C-NMR of Amino Acids and Metabolite Balancing.

A. Marx, A.A. de Graaf, W. Wiechert, L. Eggeling, H. Sahm. Jülich 240

• Remarks on Biocalorimetry and Biothermodynamics Aimed at Characterization of the Physiological State.

B. Zentgraf. Furtwangen 244

== Part 6. The Impact of Bioenergetics on Clinical and Pathologi­cal Problems.

• The Permeability Transition Pore. Pathophysiology of a Cyclosporin A-sensitive Mitochondrial Channel.

V. Petronilli, A. Nicolli, P. Costantini, R. Colonna, P. Bernardi. Padova 259

• Mitochondrial Function in the Atrial Appendage of the Human Heart. Characterization by High-Resolution Respirometry.

F.N. Gellerich, R. Steinlechner, M. Wyss, T. Eberl, L.C. Müller, D. Skladal, W. Sperl, O. Dapunt, R. Margreiter, E. Gnaiger. Innsbruck download pdf 263*

• Preservation of Mitochondrial Functions in Human Skeletal Muscle during Storage in High Energy Preservation Solution (HEPS).

D. Skladal, W. Sperl, R. Schranzhofer, M. Krismer, E. Gnaiger, R. Margreiter, F.N. Gellerich. Innsbruck download pdf 268*

• Application of Control Analysis to the Study of Metabolic Diseases in Mitochondria. Metabolic Expression of Mitochondrial DNA Mutations.

J.-P. Mazat, T. Letellier, M. Malgat, S. Jouaville, R. Morkuniene. Bordeaux, Kaunas 272

• Change in Flux Control Coefficient of Cytochrome c Oxidase in Copper Deficient Mottled Brindled Mice.

A.V. Kuznetsov, J.F. Clark, K. Winkler, W.S. Kunz. Magdeburg, Oxford download pdf 275*

• Insulin-Dependent Diabetes Mellitus in MELAS-Mitochondriopathy: Discussion of Possible Causal Relations.

K. Oexle, J. Oberle, C. Hübner 278

• Simulation of the Flow-Force Relation of Oxidative Phosphor­ylation in Complex I Deficiency.

J.A.L. Jeneson, H.V. Westerhoff. Utrecht, Amsterdam 280

• Oxygen Dependence of Cellular Respiration in Endothelial Cells: A Sensitive Toxicological Test.

R. Steinlechner, T. Eberl, R. Margreiter, E. Gnaiger. Innsbruck download pdf 283*

• Endothelial Cell Cultures as a Model for Organ Preservation Studies.

T. Eberl, R. Steinlechner, W. Salvenmoser, B. Abendstein, M. Rhomberg, H. Schröcksnadel, T. Schmid, E. Gnaiger, R. Margreiter. Innsbruck download pdf 288*

• The Effect of 2-Chlorodeoxyadenosine on Endogenous Respiration of a Human Lymphoma Cell line (U-937).

A. Knoblechner, R. Steinlechner, M. Schirmer, F.N. Gellerich, R. Margreiter, G. Konwalinka, E. Gnaiger. Innsbruck download pdf 294*

Part 7. Computer Software for Bioenergetics and Metabolic Control Analysis

• Simultaneous Estimates of Single-Enzyme Kinetic Parameters for Multi-Enzymatic Systems Using Artificial Neural Networks.

P. Mendes, D.B. Kell. Aberystwyth 302

• Design of a Software Framework for Flux Determination by 13C NMR Isotope Labelling Experiments.

W. Wiechert. Jülich 305

Announcements

• Oroboros. Grinzens-Innsbruck, Austria download pdf 316
• Acknowledgements for Financial Support 318

• Index

Subject Index 319

Author Index 325

Addresses of Participants 329